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Protein Alignment GluRIIB and GRIA2

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_000817.5	Gene:	GRIA2 / 2891	HGNCID:	4572	Length:	883	Species:	Homo sapiens

Alignment Length:	890	Identity:	242/890 - (27%)
Similarity:	409/890 - (45%)	Gaps:	130/890 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GANEDTLVIKIGAIFFDT-EMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDL 80
            ||:::....::|.:.|.| |.:|..                .:|.::    |.:|..:.:..|..
Human    36 GADQEYSAFRVGMVQFSTSEFRLTP----------------HIDNLE----VANSFAVTNAFCSQ 80

  Fly    81 IGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQF--DWHPQQSNRERMNHQLTVNVAPMELFLSA 143
            ...||.||||...|.:.:.:...|   |..|:.|  ...|...     .|...:.:.|   .|..
Human    81 FSRGVYAIFGFYDKKSVNTITSFC---GTLHVSFITPSFPTDG-----THPFVIQMRP---DLKG 134

  Fly   144 AFSDILASKTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHKAGIKMQEF---ERGDDYRILWK 202
            |...::  :.:.|..|...|:....|..||.:|   |.|:.....|.:...   ::.:.||.|::
Human   135 ALLSLI--EYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQ 197

  Fly   203 RINNAREKFVLLDCPSDILVDVIN--ASIGYNMTGSFNHLFLTNL---DTHL-------SGIDGF 255
            .:...:|:.|:|||..|.:.|:::  .:||.::.|  .|..:.||   |..|       :.:.||
Human   198 DLELKKERRVILDCERDKVNDIVDQVITIGKHVKG--YHYIIANLGFTDGDLLKIQFGGANVSGF 260

  Fly   256 YSRDFTVAVAAVRIRTYVP------PPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL--- 311
            ...|:..::.:..|..:..      |..|           |......|.|.||::.:...|.
Human   261 QIVDYDDSLVSKFIERWSTLEEKEYPGAH-----------TTTIKYTSALTYDAVQVMTEAFRNL 314

  Fly   312 ----LEISQR--PGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDF 370
                :|||:|  .|..:.|.:..   |..|..:...:||:..:.:     :..::.:.:|:|.::
Human   315 RKQRIEISRRGNAGDCLANPAVP---WGQGVEIERALKQVQVEGL-----SGNIKFDQNGKRINY 371

  Fly   371 NLEVY-----NPIIDRVTHIWNK-EFQLVDFEKLRE-NSTQALKQKRLQNKEDFSQKPIRYTVAT 428
            .:.:.     .|   |....|:: :..:|...:|.. |.|..|:.|.:             .|.|
Human   372 TINIMELKTNGP---RKIGYWSEVDKMVVTLTELPSGNDTSGLENKTV-------------VVTT 420

  Fly   429 RVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDG 493
            .:..||...::..|.:  |||||:|||.|||...:|:.|.|.:....|.|.|||:.||:|..|:|
Human   421 ILESPYVMMKKNHEML--EGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNG 483

  Fly   494 IIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWL 558
            ::.:|:...|.|.|..||||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:
Human   484 MVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWM 548

  Fly   559 FVMIAMMITAFALIFTGRIDQYEWDQPVENVNRE---MERQNIWHLSNALWLVLGSMLNQGCDLL 620
            .::.|.:..:..|....|...|||........||   .|..|.:.:.|:||..||:.:.||||:.
Human   549 CIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDIS 613

  Fly   621 PRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSV 685
            ||.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:|..
Human   614 PRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKE 678

  Fly   686 YFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQ 749
            :|..|........|..|.|.:|..|.:...|||.||:.|||.||:|:|:|..:|..||. |:..:
Human   679 FFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMK 743

  Fly   750 IGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQ-- 812
            :|.:...|.||||.|..:..|:.:::.:|:|||:|.|.||:|||: .::..|.:.    |.|.
Human   744 VGGNLDSKGYGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNKWW-YDKGECGAK----DSGSKE 803

  Fly   813 ----FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKI 853
                ..:.:|.|:|.:|:.|:.:.:::.:.||.:..:..:.:.|:
Human   804 KTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKV 848

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.