DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and GRIA1

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001244950.1	Gene:	GRIA1 / 2890	HGNCID:	4571	Length:	916	Species:	Homo sapiens

Alignment Length:	869	Identity:	245/869 - (28%)
Similarity:	406/869 - (46%)	Gaps:	96/869 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFG 90
            ::..:|.:.:.:...||..||.::.  .|...|..|. .|.:.||..:....|.....||.||||
Human    36 EVWGLFPNQQSQEHAAFRFALSQLT--EPPKLLPQID-IVNISDSFEMTYRFCSQFSKGVYAIFG 97

  Fly    91 PSSKTNSDIVEVLCNMTGIPHLQF---DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILAS- 151
            ...:..   |.:|.:..|..|:.|   .:....||      |..:.:.| ||      .|.|.|
Human    98 FYERRT---VNMLTSFCGALHVCFITPSFPVDTSN------QFVLQLRP-EL------QDALISI 146

  Fly   152 -KTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHKAGIK-MQEFERGDDYRILWKRINNAREKF 211
             ..:.|:.|...|:....|..||.:|   |.|......:. :...|.|  ||:|::.:...:|:.
Human   147 IDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEG--YRMLFQDLEKKKERL 209

  Fly   212 VLLDCPSDILVDVINASIGYNMTGSFNHLFLTNL---DTHL-------SGIDGFYSRDFTVAVAA 266
            |::||.|:.|..::...|.....|...|..|.||   |..|       :.:.||...::|..:.|
Human   210 VVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPA 274

  Fly   267 VRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL-------LEISQR--PGFYI 322
            ..::.:......|.     ..||.:.....|.|.||.:.:...|.       ::||:|  .|..:
Human   275 KIMQQWKNSDARDH-----TRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCL 334

  Fly   323 PNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFK--TQRLQINADGQREDFNLEVYNPIIDRVTHI 385
            .|.:..   |..|..:...::|:.       |:  |..:|.|..|:|.::.|.|.....|.:..|
Human   335 ANPAVP---WGQGIDIQRALQQVR-------FEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKI 389

  Fly   386 --WNKEFQLV----DFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGV 444
              ||::.:.|    |.:...:||:       :||:        .|.|.|.:..||...::...
Human   390 GYWNEDDKFVPAATDAQAGGDNSS-------VQNR--------TYIVTTILEDPYVMLKKNAN-- 437

  Fly   445 HYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICD 509
            .:|||:|:|||.|:|...:|:...:.:..|.|.|.|||:.|.:|..|:|::.:|:...|.:.:..
Human   438 QFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAP 502

  Fly   510 LTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFT 574
            ||||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:.::.|.:..:..|...
Human   503 LTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLV 567

  Fly   575 GRIDQYEWDQPVENVNREM---ERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIF 636
            .|...|||........|:.   ::.|.:.:.|:||..||:.:.||||:.||.|..|::...||.|
Human   568 SRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFF 632

  Fly   637 ALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNK 701
            .|:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:|..:|..|........|..
Human   633 TLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTY 697

  Fly   702 MLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPL 765
            |.|.:|..|.:..|||:.||:.|||.||:|:|:|..:|..||. |:..::|.:...|.||||.|.
Human   698 MKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPK 762

  Fly   766 NADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDD--GQFDMDSVGGLFVVLIVG 828
            .:..|:.:::.:|:|:|:|.|.||:|||: .::..|.|......|  ....:.:|.|:|.:||.|
Human   763 GSALRNPVNLAVLKLNEQGLLDKLKNKWW-YDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGG 826

  Fly   829 VVVGLVIGVAEFLWHVQRISVKEK 852
            :.:.:::.:.||.:..:..|.:.|
Human   827 LGLAMLVALIEFCYKSRSESKRMK 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	92/398 (23%)
		ANF_receptor	41..378	CDD:279440	87/366 (24%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	134/376 (36%)
		Lig_chan	555..822	CDD:278489	91/272 (33%)
GRIA1	NP_001244950.1	PBP1_iGluR_AMPA_GluR1	36..399	CDD:107385	92/398 (23%)
		ANF_receptor	47..382	CDD:279440	87/370 (24%)
		PBP2_iGluR_AMPA_GluR1	416..797	CDD:270447	135/391 (35%)
		Lig_chan	548..827	CDD:278489	94/279 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155798
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840