DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Grin2d

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_038951440.1	Gene:	Grin2d / 24412	RGDID:	2740	Length:	1334	Species:	Rattus norvegicus

Alignment Length:	991	Identity:	208/991 - (20%)
Similarity:	373/991 - (37%)	Gaps:	234/991 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QFLVLLALAIASGANED------------------TLVIKIGAIFFDTEMKLADAFSAALEEVNA 51
            :.|:|||||.||...|:                  ..::..|..:.....:|..|.:||:.
  Rat    15 KMLLLLALACASPFPEEVPGPGAVGGGTGGARPLNVALVFSGPAYAAEAARLGPAVAAAVR---- 75

  Fly    52 INPALKLDAIKRYVTVDD--SIVLQDISCDLIGSGV---AAIFGPSSKTN--SDIVEVLCNMTGI 109
             :|.|.:..:...:...|  |:|||  .|||: ||:   ..:|...|:..  :.|::.|...|.:
  Rat    76 -SPGLDVRPVALVLNGSDPRSLVLQ--LCDLL-SGLRVHGVVFEDDSRAPAVAPILDFLSAQTSL 136

  Fly   110 PHLQFDWHPQQSNRERMNHQLTVNVAPME---LFLSAAFS---------DILASKTFDWKSFTIA 162
            |.:            .::....:.:.|.|   .||....|         ::|  :.:||.||...
  Rat   137 PIV------------AVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVL--EEYDWTSFVAV 187

  Fly   163 YERS-SHLIRLQHI--------LAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKFVLLDCPS 218
            ..|: .|...|.:|        :.|:  |:..:.:   :.|....:|..::.:...:..||.|..
  Rat   188 TTRAPGHRAFLSYIEVLTDGSLVGWE--HRGALTL---DPGAGEAVLGAQLRSVSAQIRLLFCAR 247

  Fly   219 DILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGF---------------------------- 255
            :....|..|:....:||.....|:  :...|:|..|.
  Rat   248 EEAEPVFRAAEEAGLTGPGYVWFM--VGPQLAGGGGSGVPGEPLLLPGGSPLPAGLFAVRSAGWR 310

  Fly   256 --YSRDFTVAVAAVR------IRTY--VPPPVHDEIDVFDNSVDTRFSSLG---SQLVYDSIVLF 307
              .:|.....||.|.      :|.|  :|...|   |....:...|..||.   ..:.:|:....
  Rat   311 DDLARRVAAGVAVVARGAQALLRDYGFLPELGH---DCRTQNRTHRGESLHRYFMNITWDNRDYS 372

  Fly   308 YNALLEISQRPGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNL 372
            :|       ..||.:          .|...::...:..|.::|              |..|...|
  Rat   373 FN-------EDGFLV----------NPSLVVISLTRDRTWEVV--------------GSWEQQTL 406

  Fly   373 EVYNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNK--------EDFSQKPIRYTV--- 426
            .:..|:..|    :.:..|.||       .||.|....|:.:        :..|...||.:|
  Rat   407 RLKYPLWSR----YGRFLQPVD-------DTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCR 460

  Fly   427 --ATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTD 489
              ..|...|      .|:....| ....:|:.:|::..||....|.::...|.:.|:|......
  Rat   461 SQLNRTHSP------PPDAPRPE-KRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGV- 517

  Fly   490 EWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISIL---SYKEPPPKADI-YAFL- 549
             |:|:|.::....|.:.|..|||.:.|..:|||:|||::.|||::   |.....|.|.: :|:|
  Rat   518 -WNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWLT 581

  Fly   550 -----NPYNAEVW--LFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMER-----QNIWHLS 602
                 .||:..||  :|||...::.....||       |:..|| ..||.:..     .:.:.:.
  Rat   582 PPMSPEPYSPAVWVMMFVMCLTVVAVTVFIF-------EYLSPV-GYNRSLATGKRPGGSTFTIG 638

  Fly   603 NALWLVLGSMLNQGCDL-LPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHD 666
            .::||:...:.|....: .|||...:::...|..||::...:|.|.||||:...:....:..|.|
  Rat   639 KSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSD 703

  Fly   667 LVDQN------KVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSK 725
            ...|.      .::|||:..|:|     |.|...|   :..|.|:.........||.:.::|..|
  Rat   704 RKFQRPQEQYPPLKFGTVPNGST-----EKNIRSN---YPDMHSYMVRYNQPRVEEALTQLKAGK 760

  Fly   726 GTYAFLMETTNLQYYVQRN--CELTQIGES--FGEKHYGIAVPLNADFRSNLSVGILRLSERGEL 786
             ..||:.:...|.|..:::  |:|..||..  |....||||:...:.::..:.:.:|:.....|:
  Rat   761 -LDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEI 824

  Fly   787 FKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFL--WHVQR-IS 848
            ..|...|.:   ..|.::...:...:.|:|::.|:|.:|:|.:.:.|::...|.|  |.::. :.
  Rat   825 EMLERLWLS---GICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLG 886

  Fly   849 VKEKIPPMLALKAEFY 864
            ...::..:||.....|
  Rat   887 PTHRMDFLLAFSRGMY 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	77/435 (18%)
		ANF_receptor	41..378	CDD:279440	72/405 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	101/405 (25%)
		Lig_chan	555..822	CDD:278489	65/284 (23%)
Grin2d	XP_038951440.1	PBP1_iGluR_NMDA_NR2	46..410	CDD:380601	74/426 (17%)
		PBP2_iGluR_NMDA_Nr2	427..838	CDD:270436	106/439 (24%)
		PHA03307	<1125..>1312	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349724
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.830