DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Grik5

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	941	Identity:	261/941 - (27%)
Similarity:	450/941 - (47%)	Gaps:	115/941 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QFLVLLALAIASGANEDTLVIKIGAIFFDTEM-----KLADAFSAALEEVNAINPALKLDAIKRY 64
            :.|:||.:|.|:.:.:....:::.||..|..:     :|  |.:.|.|::|.|   :::.| |..
  Rat     4 ELLLLLIVAFANPSCQVLSSLRMAAILDDQTVCGRGERL--ALALAREQINGI---IEVPA-KAR 62

  Fly    65 VTVD------DS-IVLQDISCDLIGSGVAAIFGPSSK-TNSDIVEVLCNMTGIPHLQFDWHPQQS 121
            |.||      || ....|..|.::..||.::.||||. .::..|..:|....|||::..  |:::
  Rat    63 VEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG--PEET 125

  Fly   122 NRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGI 186
            .|.:.....:|::.|....:|.|.|.||  |:|::.|.::...::..|:||:.::....:.|..:
  Rat   126 PRLQYLRFASVSLYPSNEDVSLAVSRIL--KSFNYPSASLICAKAECLLRLEELVRGFLISKETL 188

  Fly   187 KMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSG 251
            .::..:...|...|.|.|.:.:...:::|..:.|...|:..:....||.:|....||.:|..:..
  Rat   189 SVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILH 253

  Fly   252 IDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRF-----------SSLGSQLVYDSIV 305
            :||.......:...::...::   |.:.|   |..|::..:           .:|.:.|::|::.
  Rat   254 LDGIVEDSSNILGFSMFNTSH---PFYPE---FVRSLNMSWRENCEASTYPGPALSAALMFDAVH 312

  Fly   306 LFYNALLEISQRPGFYIPNFSC-GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQRED 369
            :..:|:.|:::.....:...:| ....|..|..|:..:     :||:....|.|::.|:.|||.:
  Rat   313 VVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYL-----RMVEYDGLTGRVEFNSKGQRTN 372

  Fly   370 FNLEVYNPIIDRVTH----IWNKEFQL-VDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATR 429
            :.|.:...  .|..|    :|.....| ::...|..|.:|.|..|.|             .|.|.
  Rat   373 YTLRILEK--SRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTL-------------VVTTI 422

  Fly   430 VGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGI 494
            :..||...|  |......|||||||:.||::..||:..:|.:....|.|..||:.:.| ..|.|:
  Rat   423 LENPYVMRR--PNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPN-GSWTGM 484

  Fly   495 IRQLID-NNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWL 558
            :.:||: ..|.:.:...|||..|..|:||:.|||.||||||.......|...::||:|::..|||
  Rat   485 VGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWL 549

  Fly   559 FVMIAMMITAFALIFTGRIDQYEWDQPVENVN-REMERQNIWHLSNALWLVLGSMLNQGCDLLPR 622
            |:::|.:..:..|....|:..|||..|...:. |....:|.:.|.|:||..:|..:.||.:::||
  Rat   550 FMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPR 614

  Fly   623 GLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYF 687
            .|..|.::..||.|.|:|..:|.|.||||:|..::...:.|..||.||..:::|||..|:|..:|
  Rat   615 ALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFF 679

  Fly   688 SESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGE 752
            ..|.....:..||.|.|.:|..|.|:.|||:.||..|:  ||||:|:|..:|:.:.||.|||||.
  Rat   680 QNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGG 742

  Fly   753 SFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQ---FD 814
            ....|.|||.:||.:.||..:::.||:|.|...|..|:.||:....  |    |..:|.:   ..
  Rat   743 LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGR--C----PKEEDHRAKGLG 801

  Fly   815 MDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTY 879
            |:::||:|||||.|:::.:.:.|.||:|..:|.:..|::
  Rat   802 MENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEV-------------------------- 840

  Fly   880 RQSRDSTSTGYSSLEQITSASSAKKKKKTRR 910
                   |.....|:::..|.|.:|..::||
  Rat   841 -------SVCQEMLQELRHAVSCRKTSRSRR 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	86/396 (22%)
		ANF_receptor	41..378	CDD:279440	78/356 (22%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	139/374 (37%)
		Lig_chan	555..822	CDD:278489	97/270 (36%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	86/400 (22%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	141/388 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349752
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750