Protein Alignment GluRIIB and Grik5

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_006228444.1
• Gene: Grik5 / 24407
• RGDID: 2735
• Length: 980
• Species: Rattus norvegicus
• Alignment Length: 941
• Identity: 261/941 - (27%)
• Similarity: 450/941 - (47%)
• Gaps: 115/941 - (12%)

  Fly     5 QFLVLLALAIASGANEDTLVIKIGAIFFDTEM-----KLADAFSAALEEVNAINPALKLDAIKRY 64
            :.|:||.:|.|:.:.:....:::.||..|..:     :|  |.:.|.|::|.|   :::.| |..
  Rat     4 ELLLLLIVAFANPSCQVLSSLRMAAILDDQTVCGRGERL--ALALAREQINGI---IEVPA-KAR 62

  Fly    65 VTVD------DS-IVLQDISCDLIGSGVAAIFGPSSK-TNSDIVEVLCNMTGIPHLQFDWHPQQS 121
            |.||      || ....|..|.::..||.::.||||. .::..|..:|....|||::..  |:::
  Rat    63 VEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVG--PEET 125

  Fly   122 NRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGI 186
            .|.:.....:|::.|....:|.|.|.||  |:|::.|.::...::..|:||:.::....:.|..:
  Rat   126 PRLQYLRFASVSLYPSNEDVSLAVSRIL--KSFNYPSASLICAKAECLLRLEELVRGFLISKETL 188

  Fly   187 KMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSG 251
            .::..:...|...|.|.|.:.:...:::|..:.|...|:..:....||.:|....||.:|..:..
  Rat   189 SVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILH 253

  Fly   252 IDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRF-----------SSLGSQLVYDSIV 305
            :||.......:...::...::   |.:.|   |..|::..:           .:|.:.|::|::.
  Rat   254 LDGIVEDSSNILGFSMFNTSH---PFYPE---FVRSLNMSWRENCEASTYPGPALSAALMFDAVH 312

  Fly   306 LFYNALLEISQRPGFYIPNFSC-GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQRED 369
            :..:|:.|:::.....:...:| ....|..|..|:..:     :||:....|.|::.|:.|||.:
  Rat   313 VVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYL-----RMVEYDGLTGRVEFNSKGQRTN 372

  Fly   370 FNLEVYNPIIDRVTH----IWNKEFQL-VDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATR 429
            :.|.:...  .|..|    :|.....| ::...|..|.:|.|..|.|             .|.|.
  Rat   373 YTLRILEK--SRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTL-------------VVTTI 422

  Fly   430 VGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGI 494
            :..||...|  |......|||||||:.||::..||:..:|.:....|.|..||:.:.| ..|.|:
  Rat   423 LENPYVMRR--PNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPN-GSWTGM 484

  Fly   495 IRQLID-NNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWL 558
            :.:||: ..|.:.:...|||..|..|:||:.|||.||||||.......|...::||:|::..|||
  Rat   485 VGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWL 549

  Fly   559 FVMIAMMITAFALIFTGRIDQYEWDQPVENVN-REMERQNIWHLSNALWLVLGSMLNQGCDLLPR 622
            |:::|.:..:..|....|:..|||..|...:. |....:|.:.|.|:||..:|..:.||.:::||
  Rat   550 FMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPR 614

  Fly   623 GLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYF 687
            .|..|.::..||.|.|:|..:|.|.||||:|..::...:.|..||.||..:::|||..|:|..:|
  Rat   615 ALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFF 679

  Fly   688 SESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGE 752
            ..|.....:..||.|.|.:|..|.|:.|||:.||..|:  ||||:|:|..:|:.:.||.|||||.
  Rat   680 QNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGG 742

  Fly   753 SFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQ---FD 814
            ....|.|||.:||.:.||..:::.||:|.|...|..|:.||:....  |    |..:|.:   ..
  Rat   743 LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGR--C----PKEEDHRAKGLG 801

  Fly   815 MDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTY 879
            |:::||:|||||.|:::.:.:.|.||:|..:|.:..|::
  Rat   802 MENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEV-------------------------- 840

  Fly   880 RQSRDSTSTGYSSLEQITSASSAKKKKKTRR 910
                   |.....|:::..|.|.:|..::||
  Rat   841 -------SVCQEMLQELRHAVSCRKTSRSRR 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	84/389 (22%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	139/374 (37%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	86/400 (22%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	141/388 (36%)