DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Grin3a

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	1031	Identity:	222/1031 - (21%)
Similarity:	381/1031 - (36%)	Gaps:	272/1031 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IASGANEDTLVIKIGAIFFDTEMKLADA---FSAALEEVNAIN------PALKLDAIKRYVTVDD 69
            :..||..:||..:...:|....:...:.   ::.:||.|.||.      |.:...:.....:.|.
  Rat   113 LGEGAGAETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDP 177

  Fly    70 SIVLQDISCDLIGSGVAAIFG-PSSKTNSDIVEVLCNMTGIPHLQFDWH--PQQS---------- 121
            ...||.:...::..||:|:.. |.|:.....::::.::..||.|....|  |::|
  Rat   178 FSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSL 242

  Fly   122 -NRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSS--HLIRLQHILAWKQLHK 183
             |....:..:||::..|..:.:  ||.:|..:.::...|.:..|.:|  ||..:.:|.|.....|
  Rat   243 ENSLSSDADVTVSILTMNNWYN--FSLLLCQEDWNITDFLLLTENNSKFHLESVINITANLSSTK 305

  Fly   184 AGIKMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFL------ 242
            ..:...:.:..:        |.|:....|:..|..|.:..:...|..:.::....|..|
  Rat   306 DLLSFLQVQMDN--------IRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPELHWVLGDSQNV 362

  Fly   243 ---------TNLDTH---LSGIDGFYSRDFTVAVA-AVRIRTYVPPPVHDEIDVFD---NSVDTR 291
                     ..|..|   ...:..:|.:|....|| ||...|.:.|    |:.:..   |.:|.:
  Rat   363 EELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQP----ELALLPSTMNCMDVK 423

  Fly   292 FSSL-------------------GSQLVYDSIVLFYNALLEISQRPGFYIPNFS---CGR----- 329
            .::|                   ||..|..|.:        ||....|:|.|..   .|:
  Rat   424 TTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTI--------ISSENNFFIWNLQHDPMGKPMWTR 480

  Fly   330 -GFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLV 393
             |.|| |.|:|..                                         :.||.::.|
  Rat   481 LGSWQ-GGRIVMD-----------------------------------------SGIWPEQAQ-- 501

  Fly   394 DFEKLRENSTQALKQKRLQNKEDFSQKP--IRYTVATRVGKPYFSWRE-EPEGV----------- 444
                              ::|..| |.|  :...|.|.:..|:...|| :.||:
  Rat   502 ------------------RHKTHF-QHPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPM 547

  Fly   445 -------------HYEGNE----RFE----GYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANT 488
                         .:..|:    :|:    ||.:||:..||::..|||:...|.|.|||::  ..
  Rat   548 TNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAW--KN 610

  Fly   489 DEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYN 553
            ..|.|::..|:...|.:.:...:|..||..|:|||.||....:.|| .:.....|.|.||:.|.:
  Rat   611 GHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGIL-VRTRDTAAPIGAFMWPLH 674

  Fly   554 AEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCD 618
            ..:||.:.:|:.|||..|..      |||..|.....:...|..::..|:||.:....:..:...
  Rat   675 WTMWLGIFVALHITAIFLTL------YEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAA 733

  Fly   619 LLPRGLPM----RLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQ---FG 676
            :.|   |.    |.|...|.||.:....||.|.|||.:...||..::..:||....:..|   ||
  Rat   734 IKP---PKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFG 795

  Fly   677 TIRGGATSVYFSESNDTDNRMAWNKMLSFKPDA--FTKNNEEGVDRVKLSKGTYAFLMETTNLQY 739
            |:|..:...|..:|....:.......:...||.  :.||:.|.:|         ||:|:...|.|
  Rat   796 TVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLD---------AFIMDKALLDY 851

  Fly   740 YV--QRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCD 802
            .|  ..:|:|..:|:.|..:.|||.:|.|:...||:|..|.:....|.:..|.:||:..
  Rat   852 EVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKV------ 910

  Fly   803 SNVP-------TIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWH---VQRISVKEKIPPML 857
              ||       ..:..|..:....||||:|.:|..:.::..:.|.:.|   :.||..|.|
  Rat   911 --VPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSK----- 968

  Fly   858 ALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSASSAKKKKKTRRIEK 913
                     :::|     |||.::...:.:|.:...:|        .:.||:|:||
  Rat   969 ---------LQYW-----LHTSQRFHRALNTSFVEEKQ--------PRSKTKRVEK 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	77/441 (17%)
		ANF_receptor	41..378	CDD:279440	73/411 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	111/416 (27%)
		Lig_chan	555..822	CDD:278489	72/284 (25%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	79/447 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117		0/3 (0%)
		ANF_receptor	127..469	CDD:279440	67/363 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	110/416 (26%)
		Lig_chan	676..942	CDD:278489	76/291 (26%)
		PPP2CB binding site	951..987		11/54 (20%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349712
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830