DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIB and W02A2.5

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_502564.2	Gene:	W02A2.5 / 189098	WormBaseID:	WBGene00012190	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	507	Identity:	106/507 - (20%)
Similarity:	185/507 - (36%)	Gaps:	117/507 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 FEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANT----DEWDGIIRQLIDNNAQIGICDLTI 512
            |.|:.::::.|:....|::. ...|.....|..|..|    ..|.|::..|.:..|.........
Worm    36 FPGWTMEVLKMITDSLKWEI-IPVVTPTIVGGLDWGTLQKNGTWSGVLGYLQNGTADAVALMYQK 99

  Fly   513 TQARRSVVDFTVPFMQLGISILSYKEPPPKADIY--AFLNPYNAEVW----------LFVMIAMM 565
            |..|....:::.|...:....::.|:......:.  || .|::.|||          |.:|||:.
Worm   100 TDTRNEYFEYSYPVTNVQPVFVARKKTETLGSVLWNAF-KPFSVEVWLCLLASLVLNLLIMIAIS 163

  Fly   566 ITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLT 630
            ...|.|:|..|...:|.               :||      :|...:..:..|:|...|...::.
Worm   164 GIEFKLLFRSRFRPWEM---------------LWH------VVQLQLDEKSDDMLFYTLSGNIVL 207

  Fly   631 AFWWIFALLISQTYI-----AKLAAFITSSKIAGD-----IGSLHDLVDQNKVQFGTIRGGATSV 685
               ::||||.|...|     ..|.|.|||:   ||     ...:..|:.:.|....|...|  :.
Worm   208 ---FVFALLQSGILIEVYKGMLLTALITSN---GDNPFANADEMIKLIGEKKYHLTTNYMG--NW 264

  Fly   686 YFSESNDTDNRMAWNKMLSFKPDAFTKNN--------EEGVDRVKLSKGTYAFLMETTNLQYYVQ 742
            ||.:...:|.:    ..:|.:  |.|.:|        ...:|.|...|..|....::..:|...:
Worm   265 YFDDLQHSDQQ----HFVSLR--AATASNPVIPAASVSAALDLVDSGKYIYPIQQDSLAMQMSKE 323

  Fly   743 RNCELTQIGES---------FGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNE 798
            | |....:.:.         |.:...||     |:|.:.:      :..:..:.:..||:||...
Worm   324 R-CNYVYVSDGMPQVSSFFVFTKNFSGI-----AEFNTQI------IMNQAFIQRTFNKYFNEGF 376

  Fly   799 S-----TCDSNVPTIDDG--QFDMDSVGGLFVVLIVGVVVGLVIGVAEF--LWHVQRISVKEKI- 853
            .     .|:...||..|.  ..|::||.|:|.:..:||...|::.|.|.  .|||:.::.:.::
Worm   377 KLGFIPKCEVTEPTASDATKPLDIESVIGVFTIGALGVAASLMVFVFEIYHYWHVRILARRARMR 441

  Fly   854 PPM----LALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSASS 901
            .|.    ||..|:.:|.           |:.|..|............||:||
Worm   442 DPWNVRNLARIAQIHFT-----------THEQYSDIDVMRLVDAFNATSSSS 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377
		ANF_receptor	41..378	CDD:279440
		PBP2_iGluR_Kainate	422..795	CDD:270432	75/385 (19%)
		Lig_chan	555..822	CDD:278489	66/310 (21%)
W02A2.5	NP_502564.2	Lig_chan-Glu_bd	<36..86	CDD:214911	10/50 (20%)
W02A2.5	NP_502564.2	Periplasmic_Binding_Protein_Type_2	<74..>124	CDD:304360	7/49 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810