DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIB and T25E4.2

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001364710.1	Gene:	T25E4.2 / 188897	WormBaseID:	WBGene00020804	Length:	455	Species:	Caenorhabditis elegans

Alignment Length:	245	Identity:	55/245 - (22%)
Similarity:	98/245 - (40%)	Gaps:	48/245 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 RFEGYAVDLIYMLAQECKFDFNF-EPVRDNKY-------GSYDANTDEWDGIIRQLIDNNAQIGI 507
            |..||..|:.|:......:.||. :|..:.::       .:..|...:.|..|.|.||..:. |.
Worm     9 RAVGYQTDVPYVSLSNYCWSFNCPKPGAEVEFLNMTFQLMNSTATIVQIDADIEQSIDMVSN-GS 72

  Fly   508 CDLTITQARRSV-----VDFTVPFMQLGISILSY--KEPPPKADIYAFLNPYNAEVWLFVMIAMM 565
            .|:|:..||:::     ||||.|   :|.....|  :|.|..|     :..|...::.:..:|::
Worm    73 ADITLVSARQTLDRMKKVDFTTP---IGFVYYGYLVREIPELA-----VADYIMRLFDYDTLAIL 129

  Fly   566 ITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLT 630
            | :|.||....:..|.|          :....:..|.:.:::....:::|....:...:...:|.
Worm   130 I-SFGLIIGALLYLYTW----------IFGLRVRSLLDWMFISCSGIIHQFMFRISSPICALVLI 183

  Fly   631 AFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRG 680
            .||.:..|:|...|.|||.:|:..|...|.|             |.|:.|
Worm   184 GFWLLCCLVIITYYEAKLKSFLLLSHHRGTI-------------FNTLDG 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377
		ANF_receptor	41..378	CDD:279440
		PBP2_iGluR_Kainate	422..795	CDD:270432	55/245 (22%)
		Lig_chan	555..822	CDD:278489	25/126 (20%)
T25E4.2	NP_001364710.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900