Protein Alignment GluRIIB and nmr-2

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001256640.1
• Gene: nmr-2 / 180002
• WormBaseID: WBGene00003775
• Length: 990
• Species: Caenorhabditis elegans
• Alignment Length: 1075
• Identity: 226/1075 - (21%)
• Similarity: 393/1075 - (36%)
• Gaps: 288/1075 - (26%)

  Fly     2 HGLQFLVLLALAIASGANEDTLVIKIG-------------------AIFFDTEMKLADAFSAALE 47
            |.:.|::|| ||.....|:.   |.:|                   |:.:......:.::..|.:
 Worm     3 HRIWFILLL-LATFFEKNQS---IDLGGSRKVQKPKEDPKREDVNIAVVYQHYAGRSKSYDKAFK 63

  Fly    48 EV-NAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPH 111
            || ..||.|..:.:::|..|   ....|.:.| ::.:|...:        .::::.|||
 Worm    64 EVIRKINDATAVSSLRRLAT---RYNFQAVDC-ILPTGTFFV--------KEVLDCLCN------ 110

  Fly   112 LQFDWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHIL 176
                             .:|.|...:.:|       :.||:|:|..:....|..::.......|:
 Worm   111 -----------------NVTSNNVALIIF-------VTASETYDSTTAAEQYFLTAASYTGIPII 151

  Fly   177 AWKQLHKAGIKMQEFERG-DDYRILWKR---INNAREKFVLL---DCP-----------SDILVD 223
            || ....||.   .||.. ..|||:...   .:.||....||   :.|           :|..|.
 Worm   152 AW-NADNAGF---TFENDLGPYRIIQMAPPIEHQARAMLALLRRYNWPKFGVVTSEMAGNDRFVT 212

  Fly   224 VI--------NASIGYNMTGSFNHLFL---TNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPV 277
            .|        |.|..:.|. .|:|:..   |::|..|:.:....::...:...|.:..|     :
 Worm   213 AIREELELFSNKSTKFEMI-HFSHMNTKNDTDVDLKLADVKKNQAKIILLYANAAQAGT-----I 271

  Fly   278 HDEIDVFDNSVDTRFSSLGSQLV------------------------------YDSIV------- 305
            ....:..| .:..::..:|:|.|                              .|.|:
 Worm   272 FSHAEKMD-MIGEKYLWIGTQSVKGTQTTVKAPAQAGMLCVNFHTVSNAMFAPRDDILPLIIQLA 335

  Fly   306 --LFYNALLEISQRPGFYI-PNFSC----GRGFWQPGPRLVEQMKQITPKMVKPPF--------- 354
              ||..|||::.....|.: .|.||    |..:|..|..:.|.||....|  ..||
 Worm   336 PKLFGAALLQLRPNEMFSLKSNVSCKSEDGDPYWDNGKYIYEHMKAAFVK--GNPFHVDDGHDSF 398

  Fly   355 -----KTQR----------LQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLRE--NS 402
                 ||.|          |:.|:.|::          ..::|....|.|.::.|.:...|  |.
 Worm   399 FYTFEKTGRLRNSILQISNLRTNSKGEK----------TWEKVGIFTNNELKMADVQWPGEKANP 453

  Fly   403 TQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWRE-EPEGVHYEGNER--------------- 451
            .|....|       |..|     |.|....|:.:..: :|:.....||:.
 Worm   454 PQGAADK-------FHVK-----VVTLHEPPFIAVSDVDPDTQKCPGNQGSICDWGDVEYTDGAG 506

  Fly   452 ----------FEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIG 506
                      ..||.|||:..||.:..|.:....|||.|:|....|  .|:|:|..|:.|.|.:.
 Worm   507 VKKNRTLLKCCSGYCVDLLNKLANDIGFTYTLYKVRDEKWGLKTEN--GWNGLIADLMHNKADMC 569

  Fly   507 ICDLTITQARRSVVDFTVPFMQLGISIL-----SYKEPPPKADIYAFLNPYNAEVWLFVMIAMMI 566
            :..|.:...|...:||::||:..||||:     ....|.      |||.|:....|:.::...:.
 Worm   570 VTSLKLNSERARDIDFSLPFLDTGISIIVKIRSGVLSPT------AFLEPFEYSTWVIILFVCIH 628

  Fly   567 TAFALIFTGRIDQYEWDQPVE-NVNREMERQNIWHLSNALWLVLGSMLNQGCDL-LPRGLPMRLL 629
            .|...||.     :||..|.. |:.:....::.:.|..:.|||..::.:..... :|:....||:
 Worm   629 VAAISIFL-----FEWVSPYSFNMQKYPPPEHKFSLFRSYWLVWATLFSASVSTDVPKSTVSRLM 688

  Fly   630 TAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLV-----DQN-KVQFGTIRGGATSVYFS 688
            ...|..|.|.....|.|.||||:.:.....|:..:||.:     ||. ..:|||:.||.|
 Worm   689 ALVWAAFGLTFLAVYTANLAAFMITRVQYYDLSGIHDPMLNFPHDQKPPFRFGTVDGGNT----- 748

  Fly   689 ESNDTDNRMAWNKMLSF--KPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQR--NCELTQ 749
              ::|..| .|:||..:  ....|..|...|::.|| ::...||:.:...|.|:..:  ||.|..
 Worm   749 --HETMKR-NWHKMHEYVKHNKYFRMNISAGIEAVK-NEELDAFIYDAVVLDYWAGKDANCALMT 809

  Fly   750 IGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFD 814
            :|:......|||..|.|:...|.::..:|:..::|:|.:|:|.|. :...|.||:..| ......
 Worm   810 VGKWASMTGYGIGFPKNSPHTSLVNHYMLQYQQKGDLERLQNFWL-TGACTPDSHSQT-QSAPLG 872

  Fly   815 MDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPP-------MLALKAEFYFVIRFWLT 872
            :::....||:|..|::|.:::...|.::.:......:||.|       .:|:....
 Worm   873 IENFLSAFVLLAGGIIVSVIVLGFEHIYCMHLRKPLQKIDPNGWCGIISMAMGKSL--------- 928

  Fly   873 RKPLHTYRQSRDSTSTGYSSLEQITSASSAKKKKK 907
                 |:.::.|......|..:.:.|.:|.:.|::
 Worm   929 -----TFTEAVDRVQEWRSRTQSLASTNSPQLKRR 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	85/483 (18%)
		ANF_receptor	41..378	CDD:279440	80/434 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	106/415 (26%)
		Lig_chan	555..822	CDD:278489	69/278 (25%)
nmr-2	NP_001256640.1	rSAM_ocin_1	<54..>108	CDD:274893	11/65 (17%)
		Periplasmic_Binding_Protein_type1	102..443	CDD:385651	72/393 (18%)
		Periplasmic_Binding_Protein_Type_2	460..860	CDD:389745	109/434 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910