Protein Alignment GluRIIB and glr-2

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001021114.1
• Gene: glr-2 / 175999
• WormBaseID: WBGene00001613
• Length: 977
• Species: Caenorhabditis elegans
• Alignment Length: 959
• Identity: 249/959 - (25%)
• Similarity: 408/959 - (42%)
• Gaps: 202/959 - (21%)

  Fly    73 LQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQS---NRERMNHQLTVNV 134
            |..|.||.:..|...:...::..|..|.|.:.|...:|.:  ||.|.:|   .:...|:.:..:|
 Worm    82 LNRIICDEMKLGYMLMLAGTNFKNYGIYEDIANHMKMPLI--DWEPSKSENIGKTTENNPMIFSV 144

  Fly   135 APM--ELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEFERGDDY 197
            ||.  :|.:     |.:..|  .|:.....::..:....|:.:.::  ||:...|.|.|.  |:|
 Worm   145 APSAEQLLI-----DYIQYK--GWRDVVYIHDGKNADRTLRTMFSY--LHEKSPKYQLFV--DNY 198

  Fly   198 ------------------RILWKRINNAREKFVLLD--CPSDILVDVINASIGYNMTGSFN---- 238
                              ||..:....:.:....:|  .|.:::||         :.||:.
 Worm   199 VAPSDEEMFKEFLNEFHRRISTQHTLKSNDSSEEIDEPIPVNVIVD---------LEGSYRTRAF 254

  Fly   239 --------------HLFLTNLD---THLSGI--------------------------------DG 254
                          |...:|.|   |.|||.                                .|
 Worm   255 LRALEESVLVKKEYHYVFSNFDVDETDLSGFHFSLINITIFRIFDKNNKKFLKTRAEFHDVYRGG 319

  Fly   255 FYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIV---LFYNALLEISQ 316
            |.:.|.....||.         .||.|.|...::....:..|..:...|.|   ||...
 Worm   320 FSNTDSIPTAAAF---------AHDAILVAGKALQIAMNEHGKGIFDKSFVRHQLFNRG------ 369

  Fly   317 RPGFYIPNFSC--------GRGF--WQPGPRLVEQMKQITPKMVKPPFKTQRLQIN-ADGQREDF 370
            |.|.|     |        .|.|  ::.|.::.|.:|::. ...|....|.|:|.: ..|:|.:|
 Worm   370 RKGLY-----CRPHEDQTESRQFETFEHGKKIAEAIKKVV-LTDKDGTLTGRIQFDKVTGKRTNF 428

  Fly   371 NLEV--YNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQ--------KP--IR 423
            :.|:  ..|.::.:..||.: ||..:.|.......:.:::|    |:|.||        ||  :|
 Worm   429 SAEIVEIKPGVNSLNSIWER-FQWAEGEGFLLGGERYVQEK----KKDSSQTRKGILPSKPWQLR 488

  Fly   424 YTVATRVGKPYFSWRE----EPEGVHYEGNERFEGYAVDLIYMLAQECK-FDFNFEPVRDNKYGS 483
            :.|.|.:.||:...:.    |||   .:||:|||||.:||:.:||:... |:::......|||||
 Worm   489 FNVVTVLVKPFVMLKRRNPGEPE---LKGNDRFEGYCIDLLNLLAKNITGFEYDVFISDGNKYGS 550

  Fly   484 YDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAF 548
            ..|: ..|||:|..|::..|.:.:..|||||.|...|||:.|||..||||:..|....:.:|::|
 Worm   551 RQAD-GSWDGMIGYLLNETADVAVAPLTITQERERAVDFSKPFMTTGISIMIKKPEKQEFNIFSF 614

  Fly   549 LNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSML 613
            :.|....:|:|.:.:....:..:........||  :.:|....|....|.:.|.|:||..|.:.:
 Worm   615 MEPLGMTIWIFTLSSYFGVSLTIFLVSWFSPYE--KRIEFKRGEFTVTNEFTLYNSLWFTLAAFM 677

  Fly   614 NQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTI 678
            .||.|:|||.:..|:.::.||.|.|:|..:|.|.||||:|..::...|.|:.||.:|||:.:|..
 Worm   678 QQGTDILPRAVSGRIASSCWWFFTLIIVSSYTANLAAFLTLERMTPPIESVEDLANQNKILYGVN 742

  Fly   679 RGGATSVYFSESNDTDNRMAWNKMLSFKPD----------------AFTKNNEEGVDRVKLSKGT 727
            .||:|:.:|.:|.....:..||.|:|....                .|..:..:|:::|:.|||.
 Worm   743 EGGSTAAFFEDSIVPLYKKMWNFMVSTTQKQIELEKQSITNSTSNRIFVSSYADGIEKVRTSKGK 807

  Fly   728 YAFLM-ETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRN 791
            ||||: ||||.....:|.|:..::|::.....||||..:....|.:|::.||.|||:|||.||.|
 Worm   808 YAFLLEETTNNYESGRRPCDTMKVGQNLNTLGYGIATKIGNPLRVSLNLAILYLSEKGELKKLEN 872

  Fly   792 KWFNSNESTCDSNVPTIDDG---QFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHV--------- 844
            ||: .:...||:.  |.|.|   ..::..|.|:|.:|:.|:|:.:...:.|||:..
 Worm   873 KWW-YDRGQCDTG--TSDGGTSSSLNLSKVAGIFYILLAGMVLSMCTALVEFLFRKNKENREKER 934

  Fly   845 QRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSL 893
            .|:.....:.|.:....|       ...:|.|...|...:..||..|:|
 Worm   935 NRMRSSRPLKPGILASCE-------RAKQKQLQNRRTKSEEVSTPRSTL 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	81/413 (20%)
		ANF_receptor	41..378	CDD:279440	76/398 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	136/394 (35%)
		Lig_chan	555..822	CDD:278489	91/286 (32%)
glr-2	NP_001021114.1	Periplasmic_Binding_Protein_Type_1	7..453	CDD:299141	81/414 (20%)
		Periplasmic_Binding_Protein_Type_2	491..875	CDD:304360	134/389 (34%)
		Lig_chan	621..910	CDD:278489	93/293 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010