Protein Alignment GluRIIB and glr-4

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001254126.1
• Gene: glr-4 / 174258
• WormBaseID: WBGene00001615
• Length: 951
• Species: Caenorhabditis elegans
• Alignment Length: 887
• Identity: 234/887 - (26%)
• Similarity: 416/887 - (46%)
• Gaps: 131/887 - (14%)

  Fly     7 LVLLALAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVT----- 66
            ::|:...||:.|.:|.  ..||.|        |:..|.|.|.:..        ||.|:.|
 Worm    13 ILLVIFYIANSAADDR--FHIGTI--------ANRGSFAYEHLRY--------AIDRWNTEHGAH 59

  Fly    67 --VDDSIV--------LQDISCDLIGSGVAAIF--GPSSKTNSDIVEVLCNMTGIPHLQFDWHPQ 119
              :..|||        .::..|:::..|:.|:.  ...|:.:|.:::.:|:...||.|...   .
 Worm    60 TQIKFSIVSPIRYDNNYEERMCEIMQQGIVAVVLSNEESEQDSQLIKSMCHYFNIPCLSLQ---S 121

  Fly   120 QSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKA 184
            .|.|:.::..:|: :.|.....:.|.|:.|.|  ..|..|.:||:..|.|..|..::.:||:...
 Worm   122 TSLRDSVSDFVTL-LGPSRGAGARATSEFLDS--MRWTGFLLAYQHGSDLEDLSPLMQYKQIVDT 183

  Fly   185 G-----IKMQEFERG-DDYRILWKRINNAREKFVLLDCPSDI--LVDVINASIGYNMT-GSFNHL 240
            |     ||::..... |||....|.:....::..::...::|  |.:::..:.|.||. ..|:::
 Worm   184 GGRRIHIKIRRLPNNTDDYEPFLKYVKTRLKQTNIIIHSNNITVLYNLLQQARGLNMAEPPFSYV 248

  Fly   241 FLTNLDTHL--SGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDS 303
            | ||.|..|  ..::..|...|...:..:::       |.:     |..:.|:. :|.|:.||..
 Worm   249 F-TNTDLSLLEDFLNNMYGASFHCNITGLQL-------VKN-----DPMMKTQL-ALTSEAVYVV 299

  Fly   304 IVLFYNALLEISQRPGFYIPNFSC-GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQR 367
            .:..|. :.|:...|  ...:..| ....|..|..:.|.::::..:..    .|..:|..::|:|
 Worm   300 GMSIYR-MRELGHAP--RQSSIMCDSHDIWSDGRIMNEGIRKLKLRNQ----LTGDVQFKSNGER 357

  Fly   368 EDFNLEVYNPIIDRVTHIWNKEF-QLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVG 431
            :|.   :|:. :.|:    |.:| :|.::.:.|..:..:    |..|:.:|...|.
 Worm   358 DDI---MYHG-VGRI----NSQFVKLGNWSEKRGWNFDS----RYANRWEFDIDPD--------- 401

  Fly   432 KPYFSWREEPEGVHYE-------------GNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGS 483
                  .|:.||:|..             |..::||:.:||:..:.|..||::....|:|..||.
 Worm   402 ------SEDLEGLHLRVVVYLEEPFVIKTGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYGI 460

  Fly   484 YDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYK--EPPPKADIY 546
            .| .:..|:|||..|..:.|.:.:..:|||.:|..|||||:|||.||||||..:  |...|..::
 Worm   461 ED-ESGRWNGIIGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLARTSEETDKGSLW 524

  Fly   547 AFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW-------DQPVENVNREMERQNIWHLSNA 604
            .||.|.:..||:.::|:..|.::::....:...|||       ::..||:..:   :|.:.:.|:
 Worm   525 TFLEPLSLTVWISLLISYCIVSYSMHILAKFSPYEWYNLERIDERDFENIKNQ---KNQFTVLNS 586

  Fly   605 LWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVD 669
            .|..:||::.||.|::||....||:...||:|..:|..:|.|:||||:|..:::..|.|..||.:
 Worm   587 FWFTMGSLMQQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLAN 651

  Fly   670 QNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMET 734
            |.|:::|.::.|:|..:|.||........|:.|.|..|..|..::.||:.|||  .|.||::||:
 Worm   652 QQKIRYGVLKSGSTMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVK--SGGYAYMMES 714

  Fly   735 TNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNES 799
            :.|:||::|:|||..||.....|.||||:|..:..|..||..:|:|.||..|..|:|||:.....
 Worm   715 SMLEYYLERDCELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRRE 779

  Fly   800 TCDSNVPTIDDG-QFDMDSVGGLFVVLIVGVVVGLVIGVAEF 840
            ......|..:.. .....::.|:|.||:.|::|..::...|:
 Worm   780 GPSCGPPPSEKATNSKPQNIFGIFYVLLTGLIVAFLLACGEY 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	81/389 (21%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	132/394 (34%)
glr-4	NP_001254126.1	Periplasmic_Binding_Protein_type1	30..385	CDD:471960	85/405 (21%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:473866	128/370 (35%)