DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and glr-4

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	887	Identity:	234/887 - (26%)
Similarity:	416/887 - (46%)	Gaps:	131/887 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLLALAIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVT----- 66
            ::|:...||:.|.:|.  ..||.|        |:..|.|.|.:..        ||.|:.|
Worm    13 ILLVIFYIANSAADDR--FHIGTI--------ANRGSFAYEHLRY--------AIDRWNTEHGAH 59

  Fly    67 --VDDSIV--------LQDISCDLIGSGVAAIF--GPSSKTNSDIVEVLCNMTGIPHLQFDWHPQ 119
              :..|||        .::..|:::..|:.|:.  ...|:.:|.:::.:|:...||.|...   .
Worm    60 TQIKFSIVSPIRYDNNYEERMCEIMQQGIVAVVLSNEESEQDSQLIKSMCHYFNIPCLSLQ---S 121

  Fly   120 QSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKA 184
            .|.|:.::..:|: :.|.....:.|.|:.|.|  ..|..|.:||:..|.|..|..::.:||:...
Worm   122 TSLRDSVSDFVTL-LGPSRGAGARATSEFLDS--MRWTGFLLAYQHGSDLEDLSPLMQYKQIVDT 183

  Fly   185 G-----IKMQEFERG-DDYRILWKRINNAREKFVLLDCPSDI--LVDVINASIGYNMT-GSFNHL 240
            |     ||::..... |||....|.:....::..::...::|  |.:::..:.|.||. ..|:::
Worm   184 GGRRIHIKIRRLPNNTDDYEPFLKYVKTRLKQTNIIIHSNNITVLYNLLQQARGLNMAEPPFSYV 248

  Fly   241 FLTNLDTHL--SGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDS 303
            | ||.|..|  ..::..|...|...:..:::       |.:     |..:.|:. :|.|:.||..
Worm   249 F-TNTDLSLLEDFLNNMYGASFHCNITGLQL-------VKN-----DPMMKTQL-ALTSEAVYVV 299

  Fly   304 IVLFYNALLEISQRPGFYIPNFSC-GRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQR 367
            .:..|. :.|:...|  ...:..| ....|..|..:.|.::::..:..    .|..:|..::|:|
Worm   300 GMSIYR-MRELGHAP--RQSSIMCDSHDIWSDGRIMNEGIRKLKLRNQ----LTGDVQFKSNGER 357

  Fly   368 EDFNLEVYNPIIDRVTHIWNKEF-QLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVG 431
            :|.   :|:. :.|:    |.:| :|.::.:.|..:..:    |..|:.:|...|.
Worm   358 DDI---MYHG-VGRI----NSQFVKLGNWSEKRGWNFDS----RYANRWEFDIDPD--------- 401

  Fly   432 KPYFSWREEPEGVHYE-------------GNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGS 483
                  .|:.||:|..             |..::||:.:||:..:.|..||::....|:|..||.
Worm   402 ------SEDLEGLHLRVVVYLEEPFVIKTGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYGI 460

  Fly   484 YDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYK--EPPPKADIY 546
            .| .:..|:|||..|..:.|.:.:..:|||.:|..|||||:|||.||||||..:  |...|..::
Worm   461 ED-ESGRWNGIIGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILLARTSEETDKGSLW 524

  Fly   547 AFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEW-------DQPVENVNREMERQNIWHLSNA 604
            .||.|.:..||:.::|:..|.::::....:...|||       ::..||:..:   :|.:.:.|:
Worm   525 TFLEPLSLTVWISLLISYCIVSYSMHILAKFSPYEWYNLERIDERDFENIKNQ---KNQFTVLNS 586

  Fly   605 LWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVD 669
            .|..:||::.||.|::||....||:...||:|..:|..:|.|:||||:|..:::..|.|..||.:
Worm   587 FWFTMGSLMQQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLAN 651

  Fly   670 QNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMET 734
            |.|:::|.::.|:|..:|.||........|:.|.|..|..|..::.||:.|||  .|.||::||:
Worm   652 QQKIRYGVLKSGSTMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVK--SGGYAYMMES 714

  Fly   735 TNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNES 799
            :.|:||::|:|||..||.....|.||||:|..:..|..||..:|:|.||..|..|:|||:.....
Worm   715 SMLEYYLERDCELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRRE 779

  Fly   800 TCDSNVPTIDDG-QFDMDSVGGLFVVLIVGVVVGLVIGVAEF 840
            ......|..:.. .....::.|:|.||:.|::|..::...|:
Worm   780 GPSCGPPPSEKATNSKPQNIFGIFYVLLTGLIVAFLLACGEY 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	83/396 (21%)
		ANF_receptor	41..378	CDD:279440	76/365 (21%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	132/394 (34%)
		Lig_chan	555..822	CDD:278489	88/274 (32%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	85/405 (21%)
		ANF_receptor	45..365	CDD:279440	73/358 (20%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	128/370 (35%)
		Lig_chan	533..810	CDD:278489	91/281 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020