DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Grin3b

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_579842.2	Gene:	Grin3b / 170796	RGDID:	621705	Length:	1002	Species:	Rattus norvegicus

Alignment Length:	1047	Identity:	229/1047 - (21%)
Similarity:	349/1047 - (33%)	Gaps:	336/1047 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLLALAIAS----------------GANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPAL 56
            |.||||:.|                ||:     :::.|:........|...:|.......:...|
  Rat    11 VALALAVGSRVVRGHPQPCRVPTRAGAS-----VRLAALLPRAPAARARVLAALATPAPRLPHNL 70

  Fly    57 KLDAIKRYVTVDDSIVLQDISCDLIG--SGVAAIFGPSSKTNSDIVEVLCNMTGIP--------- 110
            .|:.:.......|...|....|.::.  ..||:|..|.::....:::.|...|..|
  Rat    71 SLELVAVASPTRDPASLARGLCQVLAPPGVVASIAFPEARPELRLLQFLAAATETPVVSVLRREV 135

  Fly   111 ----------HLQFDWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYER 165
                      |||.||                 .:|:|..|     |:|.|
  Rat   136 RTALGAPTPFHLQLDW-----------------ASPLETIL-----DVLVS-------------- 164

  Fly   166 SSHLIRLQHILAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKFVL----LDCPSDILVDVIN 226
               |:|..   ||:.:.....::::   ......||....:...||||    ||..:|.|
  Rat   165 ---LVRAH---AWEDIALVLCRVRD---PGSLVTLWTNHASQAPKFVLDLSRLDSRNDSL----- 215

  Fly   227 ASIGYNMTGSFN-------HLFLTNLDTHLSGIDGFYSRDFTVAVAAV-----RIRTYVP----- 274
             ..|..:.|:..       ...|....|         :|...|..||.     .:.|.:|
  Rat   216 -RAGLALLGALEGGGTPVPAAVLLGCST---------ARAHEVLEAAPPGPQWLLGTPLPAEALP 270

  Fly   275 ----PP----------------VHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEI----- 314
                ||                |||.:::    |....||:.  ||:..     .|||..
  Rat   271 TTGLPPGVLALGETEQHSLEAVVHDMVEL----VAQALSSMA--LVHPE-----RALLPAVVNCD 324

  Fly   315 ------SQRPGFYIPNFSCGRGF-------WQPGPRLVEQMKQITPKMVKPPFKTQRLQIN---- 362
                  |:..|..:..|.....|       |..|...|.         |...||...|:.:
  Rat   325 DLKTGGSEATGRTLARFLGNTSFQGRTGAVWVTGSSQVH---------VSRHFKVWSLRRDPLGA 380

  Fly   363 ---------ADGQREDFN-----LEVYNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQN 413
                     .|||. ||.     |.|.:|                       :.|||..:.|
  Rat   381 PAWATVGSWQDGQL-DFQPGAAALRVPSP-----------------------SGTQARPKLR--- 418

  Fly   414 KEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNE-----------RFE-------------- 453
                        |.|.|..|:...||..|.......:           |.:
  Rat   419 ------------VVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRT 471

  Fly   454 ------GYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTI 512
                  ||.:||:..||::..|||....|.|.|||:  .....|.|::..|:...|.:.:...:|
  Rat   472 LRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGA--LRDGRWTGLVGDLLAGRAHMAVTSFSI 534

  Fly   513 TQARRSVVDFTVPFM--QLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTG 575
            ..||..|||||.||.  .|||.:.:.....|   |.||:.|.:..:|:.|..|:.:||..|..
  Rat   535 NSARSQVVDFTSPFFSTSLGIMVRTRDTASP---IGAFMWPLHWSMWVGVFAALHLTALFLTL-- 594

  Fly   576 RIDQYEWDQPVENVNREMERQNIWHLSNALWL----VLGSMLNQGCDLLPRGLPMRLLTAFWWIF 636
                |||..|.....|...|..::..|:||.|    :.|..::......|.|   |.|...|.||
  Rat   595 ----YEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTG---RFLMNLWAIF 652

  Fly   637 ALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQ---FGTIRGGATSVYFSESNDTDNRMA 698
            .||:..:|.|.|||.:...|...::..:||....:..|   |||:...:...|...|
  Rat   653 CLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKAS-------- 709

  Fly   699 WNKMLSFKPDAFTKNNEEGV-----DRVKLSKGTYAFLMETTNLQYYV--QRNCELTQIGESFGE 756
            :.:|.:............||     |..||:    ||:|:.:.|.|.|  ..:|:|..:|:.|..
  Rat   710 FPEMHAHMRRHSAPTTPHGVAMLTSDPPKLN----AFIMDKSLLDYEVSIDADCKLLTVGKPFAI 770

  Fly   757 KHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDG-QFDMDSVGG 820
            :.|||.:|.|:...||||..|.|....|.:..|.:||:..  ..|...|..:.:. |..:....|
  Rat   771 EGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKM--VPCGKRVFAVTETLQMGVYHFSG 833

  Fly   821 LFVVLIVGVVVGLVIGVAEFLWH---VQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQS 882
            |||:|.:|:...|:..:.|.:::   :.||....|              :::|     |||.::.
  Rat   834 LFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNK--------------LQYW-----LHTSQKI 879

  Fly   883 RDSTSTG 889
            ..:.:||
  Rat   880 HRALNTG 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	82/464 (18%)
		ANF_receptor	41..378	CDD:279440	79/434 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	115/419 (27%)
		Lig_chan	555..822	CDD:278489	75/281 (27%)
Grin3b	NP_579842.2	PBP1_iGluR_NMDA_NR3	21..405	CDD:107372	82/469 (17%)
		PBP2_iGluR_NMDA_Nr3	414..808	CDD:270438	115/434 (26%)
		Lig_chan	576..842	CDD:278489	79/288 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..910		2/5 (40%)
		Involved in the trafficking and surface expression of NMDARs. /evidence=ECO:0000250	951..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930