DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Grin2d

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_036008580.1	Gene:	Grin2d / 14814	MGIID:	95823	Length:	1345	Species:	Mus musculus

Alignment Length:	843	Identity:	175/843 - (20%)
Similarity:	315/843 - (37%)	Gaps:	167/843 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 WHPQQSNRERMNHQLTVNVAPMELFLSA-----AFSDILASKTFDWKSFTIAYERS-SHLIRLQH 174
            |.|..|.:|: .|:.......::|..|.     ...::|  :.:||.||.....|: .|...|.:
Mouse   144 WPPAISPKEQ-GHEKEKGSTFLQLGSSTEQQLQVIFEVL--EEYDWTSFVAVTTRAPGHRAFLSY 205

  Fly   175 I--------LAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGY 231
            |        :.|:  |:..:.:   :.|....:|..::.:...:..||.|..:....|..|:...
Mouse   206 IEVLTDGSLVGWE--HRGALTL---DPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEA 265

  Fly   232 NMTGSFNHLFLTNLDTHLSGIDGFYSRDFTV--------AVAAVRIRTYVPPPVHDEIDVFDNSV 288
            .:||.....|:........|..|.......:        .:.|||...:     .|::
Mouse   266 GLTGPGYVWFMVGPQLAGGGGSGVPGEPLLLPGGAPLPAGLFAVRSAGW-----RDDL------- 318

  Fly   289 DTRFSSLGSQLV---YDSIVLFYNALLEISQRPGFYIPNFSC-GRGFWQPGPRLVEQMKQITPKM 349
             .|..:.|..:|   ..:::..|..|.|:..         .| .:.....|..|......||
Mouse   319 -ARRVAAGVAVVARGAQALLRDYGFLPELGH---------DCRAQNRTHRGESLHRYFMNIT--- 370

  Fly   350 VKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHI---WNKEFQLVDFEKLRENSTQALKQKRL 411
                :..:....|.||...:.:|.|.:...||...:   |             |..|..||....
Mouse   371 ----WDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSW-------------EQQTLRLKYPLW 418

  Fly   412 QNKEDFSQKPI----RYTVATRVGKPY------------------------------FSWREEPE 442
            .....|.| |:    ..||||...:|:                              .:.|..|.
Mouse   419 SRYGRFLQ-PVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSLVAPRSPPP 482

  Fly   443 GVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGI 507
            ..........:|:.:|::..||....|.::...|.:.|:|......  |:|:|.::....|.:.|
Mouse   483 DAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGV--WNGMIGEVFYQRADMAI 545

  Fly   508 CDLTITQARRSVVDFTVPFMQLGISIL---SYKEPPPKADI-YAFL------NPYNAEVW--LFV 560
            ..|||.:.|..:|||:|||::.|||::   |.....|.|.: :|:|      .||:..||  :||
Mouse   546 GSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLAFAWLMPPMSPEPYSPAVWVMMFV 610

  Fly   561 MIAMMITAFALIFTGRIDQYEWDQPVENVNREMER-----QNIWHLSNALWLVLGSMLNQGCDL- 619
            |...::.....||       |:..|| ..||.:..     .:.:.:..::||:...:.|....:
Mouse   611 MCLTVVAVTVFIF-------EYLSPV-GYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVE 667

  Fly   620 LPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQN------KVQFGTI 678
            .|||...:::...|..||::...:|.|.||||:...:....:..|.|...|.      .::|||:
Mouse   668 NPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTV 732

  Fly   679 RGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQR 743
            ..|:|     |.|...|   :..|.|:.........||.:.::|..| ..||:.:...|.|..::
Mouse   733 PNGST-----EKNIRSN---YPDMHSYMVRYNQPRVEEALTQLKAGK-LDAFIYDAAVLNYMARK 788

  Fly   744 N--CELTQIGES--FGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSN 804
            :  |:|..||..  |....||||:...:.::..:.:.:|:.....|:..|...|.:   ..|.::
Mouse   789 DEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLS---GICHND 850

  Fly   805 VPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFL--WHVQR-ISVKEKIPPMLALKAEFY 864
            ...:...:.|:|::.|:|.:|:|.:.:.|::...|.|  |.::. :....::..:||.....|
Mouse   851 KIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMY 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	53/305 (17%)
		ANF_receptor	41..378	CDD:279440	50/287 (17%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	101/434 (23%)
		Lig_chan	555..822	CDD:278489	65/284 (23%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:415822	51/307 (17%)
Grin2d	XP_036008580.1	PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	102/438 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846255
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.830