DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Grin2c

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_017169765.1	Gene:	Grin2c / 14813	MGIID:	95822	Length:	1307	Species:	Mus musculus

Alignment Length:	982	Identity:	204/982 - (20%)
Similarity:	371/982 - (37%)	Gaps:	244/982 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLLAL-----AIASGANEDTLVIKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYV- 65
            |:|.:|     .:.:|..|..:.:   |:.|.:...|.......|...|.::..|::..:...|
Mouse    71 LLLTSLLGAWAGLGAGQGEQAVTV---AVVFGSSGPLQAQARTRLTPQNFLDLPLEIQPLTIGVN 132

  Fly    66 TVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSD------IVEVLCNMTGIPHLQFD------WHP 118
            ..:.|.:|..| |.|:|:  |.:.|...:.|.|      :::.:.:.|.:|.|...      ..|
Mouse   133 NTNPSSILTQI-CGLLGA--ARVHGIVFEDNVDTEAVAQLLDFVSSQTHVPILSISGGSAVVLTP 194

  Fly   119 QQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYE-RSSHLIRLQHI------- 175
            ::.....:  ||.|:   :|..|...|..:   :.:||.:|.:... ...|.:.|:.:
Mouse   195 KEPGSAFL--QLGVS---LEQQLQVLFKVL---EEYDWSAFAVITSLHPGHALFLEGVRAVADAS 251

  Fly   176 -LAWKQLHKAGIKM---------QEFERGDDYRILWKRINNAREKFVLLDCPSDILVD------V 224
             |:|:.|....:::         |...|..|..:|....:....:.:..:.....||.      |
Mouse   252 YLSWRLLDVLTLELGPGGPRARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLV 316

  Fly   225 INASIGYN--------------MTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTY--- 272
            .|.::|..              :|.|:      .|.......||       ||:.|:...:|
Mouse   317 PNLALGSTDAPPAAFPVGLISVVTESW------RLSLRQKVRDG-------VAILALGAHSYRRQ 368

  Fly   273 ---VPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEISQRPGFYIPNFSCGRGF-WQ 333
               :|.|          :.|.| |..|.  |..:...||..||.::..          ||.| :.
Mouse   369 YGTLPAP----------AGDCR-SHPGP--VSPAREAFYRHLLNVTWE----------GRDFSFS 410

  Fly   334 PGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTH--------IWNKEF 390
            ||..||:      |.||.......||.                .::.|..|        :|.:
Mouse   411 PGGYLVQ------PTMVVIALNRHRLW----------------EMVGRWDHGVLYMKYPVWPR-- 451

  Fly   391 QLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGV----------H 445
                    ...|.|.:...|            ..||||...:|:........|.          .
Mouse   452 --------YSTSLQPVVDSR------------HLTVATLEERPFVIVESPDPGTGGCVPNTVPCR 496

  Fly   446 YEGNERF-------------EGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQ 497
            .:.|..|             :|:.:|::..||:..||.::...|.:.|:|......  |:|:|.:
Mouse   497 RQSNHTFSSGDITPYTKLCCKGFCIDILKKLAKVVKFSYDLYLVTNGKHGKRVRGV--WNGMIGE 559

  Fly   498 LIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISIL---SYKEPPPKADIYAFLNPYNAEVWLF 559
            :....|.:.|..|||.:.|..::||:|||::.|||::   |.....|.    |||.||:..||:
Mouse   560 VYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPS----AFLEPYSPAVWV- 619

  Fly   560 VMIAMMITAFALIFTGRIDQYEWDQPVE-NVNREMERQN---IWHLSNALWLVLGSMLNQGCDL- 619
            :|..|.:|..|:    .:..:|:..||. |.|....:::   .:.:..::||:...:.|....:
Mouse   620 MMFVMCLTVVAI----TVFMFEYFSPVSYNQNLTKGKKSGGPSFTIGKSVWLLWALVFNNSVPIE 680

  Fly   620 LPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQN------KVQFGTI 678
            .|||...:::...|..||::...:|.|.||||:...:....:..|.|...|.      ..:|||:
Mouse   681 NPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTV 745

  Fly   679 RGGATSVYFSESNDTDN-RMAWNKMLSFKPDAFTKNNEEGVDRVKL-----SKGTYAFLMETTNL 737
            ..|:|     |.|...| |.....|:.|.    .::.|:.:..:|:     |:...||:.:...|
Mouse   746 PNGST-----ERNIRSNYRDMHTHMVKFN----QRSVEDALTSLKMGARHVSRKLDAFIYDAAVL 801

  Fly   738 QYYVQRN--CELTQIGES--FGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNE 798
            .|...::  |:|..||..  |....||||:..::.::..:.:.:|:....||..||...|.:
Mouse   802 NYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLS--- 863

  Fly   799 STCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLW-HVQRISVKEKIPPMLALKAE 862
            ..|.:....:...:.|:|::.|:|.:|:|.:.:.|::    |.| |:....::..:|.    .::
Mouse   864 GICHNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLV----FAWEHLVYWKLRHSVPS----SSQ 920

  Fly   863 FYFVIRF 869
            ..|::.|
Mouse   921 LDFLLAF 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	79/432 (18%)
		ANF_receptor	41..378	CDD:279440	73/394 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	103/419 (25%)
		Lig_chan	555..822	CDD:278489	66/287 (23%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	78/427 (18%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	105/440 (24%)
		NMDAR2_C	905..>980	CDD:371139	4/27 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830