DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Grin2b

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_001350679.1	Gene:	Grin2b / 14812	MGIID:	95821	Length:	1482	Species:	Mus musculus

Alignment Length:	926	Identity:	197/926 - (21%)
Similarity:	365/926 - (39%)	Gaps:	179/926 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FLVLLALAIASG---ANEDTLVIKIGAIFFDT--EMKLADAFSAALEEVNAINPALKLDAIKRYV 65
            :|||..||::..   :.:....|.|..|...|  |:.:.||...  ::.:.::...:::.:....
Mouse    13 WLVLAVLAVSGSKARSQKSAPSIGIAVILVGTSDEVAIKDAHEK--DDFHHLSVVPRVELVAMNE 75

  Fly    66 TVDDSIVLQDISCDLIG----SGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERM 126
            |...||:.:  .|||:.    .||........:..:.|::.:...|..|.|...........::.
Mouse    76 TDPKSIITR--ICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKD 138

  Fly   127 NHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTI------AYERSSHLIRL---QHILAWKQLH 182
            ...:.....|.....::...:|:  :.:||..|:|      .|:...:.||.   ...:.| :|.
Mouse   139 ESSMFFQFGPSIEQQASVMLNIM--EEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGW-ELE 200

  Fly   183 KAGIKMQEFERGDDYRILWKRINNAREK----FVLLDCPSD---ILVDVINA--SIGYNMTGSFN 238
            :..:.....:.||      .:|.|..:|    .:||.|..:   .:.:|.|:  ..||..|....
Mouse   201 EVLLLDMSLDDGD------SKIQNQLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVP 259

  Fly   239 HLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDS 303
            .|...:.||..|        :|...:.:|            ..|.:|..:..|        |.|.
Mouse   260 SLVAGDTDTVPS--------EFPTGLISV------------SYDEWDYGLPAR--------VRDG 296

  Fly   304 IVLFYNALLEISQRPGFY-IPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQR 367
            |.:...|..::.....|. .|..||    :....:.:.|...:...::...|:.:.|..:.||.:
Mouse   297 IAIITTAASDMLSEHSFIPEPKSSC----YNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQ 357

  Fly   368 EDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNK---------EDFSQKPIR 423
            ....|         |..:.|||.:   :|::.:     .|.|.||.|         |...|:...
Mouse   358 MHPKL---------VIILLNKERK---WERVGK-----WKDKSLQMKYYVWPRMCPETEEQEDDH 405

  Fly   424 YTVATRVGKPYF---------------------------SWREEPEGVHYEGNERFEGYAVDLIY 461
            .::.|....|:.                           ...|||..:    .:..:|:.:|::.
Mouse   406 LSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEPGYI----KKCCKGFCIDILK 466

  Fly   462 MLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPF 526
            .:::..||.::...|.:.|:|.....|  |:|:|.:::...|.:.:..|||.:.|..||||:|||
Mouse   467 KISKSVKFTYDLYLVTNGKHGKKINGT--WNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPF 529

  Fly   527 MQLGISIL---SYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVEN 588
            ::.|||::   |.....|.    |||.|::|:||:.:.:.::|.:...:|.     :|:..|| .
Mouse   530 IETGISVMVSRSNGTVSPS----AFLEPFSADVWVMMFVMLLIVSAVAVFV-----FEYFSPV-G 584

  Fly   589 VNREMERQN-----IWHLSNALWLVLGSMLNQGCDLL-PRGLPMRLLTAFWWIFALLISQTYIAK 647
            .||.:....     .:.:..|:||:.|.:.|....:. |:|...:::.:.|..||::...:|.|.
Mouse   585 YNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTAN 649

  Fly   648 LAAFITSSKIAGDIGSLHDLVDQN------KVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFK 706
            ||||:...:....:..|.|...|.      ..:|||:..|:|     |.|..:|....:..:.
Mouse   650 LAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGST-----ERNIRNNYAEMHAYMG-- 707

  Fly   707 PDAFTKNNEEGVDRVKLSKGT---YAFLMETTNLQYYVQRN--CELTQIGES--FGEKHYGIAVP 764
                 |.|:.|||...||..|   .||:.:...|.|...|:  |:|..||..  |....||||:.
Mouse   708 -----KFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQ 767

  Fly   765 LNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGV 829
            .::.::..:.:.||:|...||:.:|...|..   ..|.:....:...|.|:|::.|:|.:|...:
Mouse   768 KDSGWKRQVDLAILQLFGDGEMEELEALWLT---GICHNEKNEVMSSQLDIDNMAGVFYMLGAAM 829

  Fly   830 VVGLVIGVAEFLWHVQ 845
            .:.|:..:.|.|::.|
Mouse   830 ALSLITFICEHLFYWQ 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	69/391 (18%)
		ANF_receptor	41..378	CDD:279440	60/359 (17%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	103/421 (24%)
		Lig_chan	555..822	CDD:278489	70/285 (25%)
Grin2b	NP_001350679.1	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601	75/416 (18%)
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	104/430 (24%)
		NMDAR2_C	840..1482	CDD:402274	2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846231
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840