Protein Alignment GluRIIB and Grin2a

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_032196.2
• Gene: Grin2a / 14811
• MGIID: 95820
• Length: 1464
• Species: Mus musculus
• Alignment Length: 966
• Identity: 209/966 - (21%)
• Similarity: 380/966 - (39%)
• Gaps: 225/966 - (23%)

  Fly     7 LVLLALAIASG------ANEDTLVIKIGAIFFD----TEMKLADAFSAALEEVNAINPALKLDAI 61
            |||.||.:..|      |.:.|..:.|..:...    ||.:|.:.:..  |:...:...:.:.|:
Mouse    10 LVLPALLVWHGPAQNAAAEKGTPALNIAVLLGHSHDVTERELRNLWGP--EQATGLPLDVNVVAL 72

  Fly    62 KRYVTVDDSIVLQDISCDLIGSGV---AAIFGPSS--KTNSDIVEVLCNMTGIPHL--------- 112
            ....|...|::..  .|||: ||.   ..:||..:  :..:.:::.:.:.|.||.|
Mouse    73 LMNRTDPKSLITH--VCDLM-SGARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMI 134

  Fly   113 -----------QFDWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTI----- 161
                       ||....||        |.||.:..|:              .:||..|::
Mouse   135 MADKDPTSTFFQFGASIQQ--------QATVMLKIMQ--------------DYDWHVFSLVTTIF 177

  Fly   162 -AYERSSHLIRL---QHILAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKFVLLDCPSDILV 222
             .|......|:.   ...:.|...:...:. ..||.... ::..|:|:::   .:||.|..|..|
Mouse   178 PGYRDFISFIKTTVDNSFVGWDMQNVITLD-TSFEDAKT-QVQLKKIHSS---VILLYCSKDEAV 237

  Fly   223 DVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNS 287
            .:::.:....:||   :.|...:.:.:||......::|...:.:|            ..|.:|.|
Mouse   238 LILSEARSLGLTG---YDFFWIVPSLVSGNTELIPKEFPSGLISV------------SYDDWDYS 287

  Fly   288 VDTRFSSLGSQLVYDSIVLFYNALLEISQRPGFYIP--NFSCGRGFWQPGPRLVEQMKQITPKMV 350
            ::.|        |.|.:.:...|...:.::.. |||  ..||   :.|            |.|..
Mouse   288 LEAR--------VRDGLGILTTAASSMLEKFS-YIPEAKASC---YGQ------------TEKPE 328

  Fly   351 KPPFKTQRLQINA--DGQREDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLR--ENSTQALKQ--- 408
            .|.....:..:|.  ||:...|..|.|......|..:.||:   .::||:.  ||.|.:|:.
Mouse   329 TPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKD---REWEKVGKWENQTLSLRHAVW 390

  Fly   409 KRLQNKEDFSQKPIRYTVATRVGKPYFSWRE-EP-----------------------EGVHYEGN 449
            .|.::..|........::.|....|:....: :|                       ||::.:
Mouse   391 PRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVK-- 453

  Fly   450 ERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQ 514
            :..:|:.:|::..|::..||.::...|.:.|:|....|.  |:|:|.:::...|.:.:..|||.:
Mouse   454 KCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNV--WNGMIGEVVYQRAVMAVGSLTINE 516

  Fly   515 ARRSVVDFTVPFMQLGISIL---SYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGR 576
            .|..||||:|||::.|||::   |.....|.    |||.|::|.||:.:.:.::|.:...:|.
Mouse   517 ERSEVVDFSVPFVETGISVMVSRSNGTVSPS----AFLEPFSASVWVMMFVMLLIVSAIAVFV-- 575

  Fly   577 IDQYEWDQPVENVNREMERQNIWH-----LSNALWLVLGSMLNQGCDLL-PRGLPMRLLTAFWWI 635
               :|:..|| ..||.:.:....|     :..|:||:.|.:.|....:. |:|...:::.:.|..
Mouse   576 ---FEYFSPV-GYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAF 636

  Fly   636 FALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQN------KVQFGTIRGGATSVYFSESNDTD 694
            ||::...:|.|.||||:...:....:..|.|...|.      ..:|||:..|:|     |.|..:
Mouse   637 FAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGST-----ERNIRN 696

  Fly   695 NRMAWNKMLSFKPDAFTKNNEEGVD--RVKLSKGTY-AFLMETTNLQYYVQRN--CELTQIGES- 753
            |       ..:.....||.|:.||:  .|.|..|.. ||:.:...|.|...|:  |:|..||..
Mouse   697 N-------YPYMHQYMTKFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGY 754

  Fly   754 -FGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDS 817
             |....||||:...:.::..:.:.:|:....||:.:|...|..   ..|.:....:...|.|:|:
Mouse   755 IFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT---GICHNEKNEVMSSQLDIDN 816

  Fly   818 VGGLFVVLIVGVVVGLVIGVAEFLW-HVQRISVKEKIPPMLALKAEFYFVIRFWLT 872
            :.|:|.:|...:.:.|:    .|:| |:                  ||:.:||..|
Mouse   817 MAGVFYMLAAAMALSLI----TFIWEHL------------------FYWKLRFCFT 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	74/408 (18%)
		ANF_receptor	41..378	CDD:279440	67/374 (18%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	103/418 (25%)
		Lig_chan	555..822	CDD:278489	69/285 (24%)
Grin2a	NP_032196.2	PBP1_iGluR_NMDA_NR2	32..392	CDD:107373	80/433 (18%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	104/427 (24%)
		HisJ	<458..>541	CDD:223904	27/84 (32%)
		Lig_chan	556..828	CDD:278489	71/292 (24%)
		NMDAR2_C	839..1464	CDD:287527	6/30 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846235
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930