DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Grik1

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	959	Identity:	270/959 - (28%)
Similarity:	464/959 - (48%)	Gaps:	143/959 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VIKIGAIFFDTEMKLAD----AFSAALEEVN-----AINPALKLDAIKRYVTVDDSIVLQDISCD 79
            |::||.||...|.:..:    ||..|:..:|     ..|..|..| |:| :.:.||......:||
Mouse    36 VLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYD-IQR-INLFDSFEASRRACD 98

  Fly    80 LIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDW-HPQQSNRERMNHQLTVNVAPMELFLSA 143
            .:..||||:||||..::...|:.:||...:||:|..| ||...||:    ...:|:.|....:|.
Mouse    99 QLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNRD----LFYINLYPDYAAISR 159

  Fly   144 AFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKMQEFERGD-DYRILWKRINNA 207
            |..|::.  .::||:.|:.||.|:.|||||.::.....:...||:::...|: |.:.|.|.:...
Mouse   160 AVLDLVL--YYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKG 222

  Fly   208 REKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLD-------------------------- 246
            :|.:|:.||..:...:::...:...|...:.|.|.|.||
Mouse   223 KEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDN 287

  Fly   247 THLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL 311
            .|:|.|...:|.:          |...||  ..|..:.|..:.|.     :.|:||::.:...|.
Mouse   288 PHVSSIIEKWSME----------RLQAPP--RPETGLLDGVMTTE-----AALMYDAVYMVAIAS 335

  Fly   312 LEISQRPGFYIPNFSCGRGF-WQPGPRLVEQMKQITPKMVKPPFKTQRLQIN-ADGQREDFNLEV 374
            ...||   ..:.:..|.|.. |:.|||.:..:|:     .:....|.|:..| .||.|:||:|::
Mouse   336 HRASQ---LTVSSLQCHRHKPWRLGPRFMNLIKE-----ARWDGLTGRITFNKTDGLRKDFDLDI 392

  Fly   375 YN-----------PIIDRVTHIW--------NKEFQLVDFEKLRENS-TQALKQKRLQNKEDFSQ 419
            .:           .:...:..:|        |....:.|..:.|.|: |.:|..:.|
Mouse   393 ISLKEEGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTL-------- 449

  Fly   420 KPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSY 484
                 .|.|.:.:||..:|:..:.::  ||:|||||.:||:..|:....|.::.:.|.|.|||:.
Mouse   450 -----IVTTILEEPYVMYRKSDKPLY--GNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQ 507

  Fly   485 DANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFL 549
            : :..||:|::::|||:.|.:.:..||||..|..|:||:.|||.||||||..|.......:::||
Mouse   508 N-DKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFL 571

  Fly   550 NPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVE-NVNREMERQNIWHLSNALWLVLGSML 613
            ||.:.::|::|::|.:..:..|....|...|||..|.. |.:.::...| :.|.|:.|..:|:::
Mouse   572 NPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENN-FTLLNSFWFGVGALM 635

  Fly   614 NQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTI 678
            .||.:|:|:.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||..|.|:::|.:
Mouse   636 QQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAV 700

  Fly   679 RGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQR 743
            |.|:|..:|.:|..:.....|..|.|.:..|..||::||:.||..:  .||.|||:|:::|..||
Mouse   701 RDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTT--DYALLMESTSIEYVTQR 763

  Fly   744 NCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTI 808
            ||.|||||.....|.||:..|:.:.:|..:::.||:|.|.|:|..::.||:..|      ..|..
Mouse   764 NCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN------GCPEE 822

  Fly   809 DDGQ---FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQR---ISVKEKIPPMLALKAEFYFVI 867
            |..:   ..::::||:|:||..|:|:.:.:.:.||::..::   |..|.|     :.:..|||
Mouse   823 DSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQKGK-----SSRLRFYF-- 880

  Fly   868 RFWLTRKPLHTYRQSRDSTST----GYSSLEQ---ITSASSAKKKKKTR 909
                 |..:..:....:|...    .::::.:   |:..:..|.|||:|
Mouse   881 -----RNKVRFHGSKTESLGVEKCLSFNAIMEELGISLKNQKKLKKKSR 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	103/424 (24%)
		ANF_receptor	41..378	CDD:279440	96/382 (25%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	134/373 (36%)
		Lig_chan	555..822	CDD:278489	89/270 (33%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	103/425 (24%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	135/387 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846251
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750