DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluRIIB and Gria1

DIOPT Version :9

Sequence 1:NP_523485.3 Gene:GluRIIB / 33789 FlyBaseID:FBgn0020429 Length:913 Species:Drosophila melanogaster
Sequence 2:NP_001106796.1 Gene:Gria1 / 14799 MGIID:95808 Length:907 Species:Mus musculus


Alignment Length:872 Identity:247/872 - (28%)
Similarity:409/872 - (46%) Gaps:100/872 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 IKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIF 89
            |:||.:|.:.:.:...||..||.::.  .|...|..|. .|.:.||..:....|.....||.|||
Mouse    25 IQIGGLFPNQQSQEHAAFRFALSQLT--EPPKLLPQID-IVNISDSFEMTYRFCSQFSKGVYAIF 86

  Fly    90 GPSSKTNSDIVEVLCNMTGIPHLQF---DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILAS 151
            |...:..   |.:|.:..|..|:.|   .:....||      |..:.:.|.   |..|...|:  
Mouse    87 GFYERRT---VNMLTSFCGALHVCFITPSFPVDTSN------QFVLQLRPE---LQEALISII-- 137

  Fly   152 KTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHKAGIK-MQEFERGDDYRILWKRINNAREKFV 212
            ..:.|::|...|:....|..||.:|   |.|......:. :...|.|  ||:|::.:...:|:.|
Mouse   138 DHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEG--YRMLFQDLEKKKERLV 200

  Fly   213 LLDCPSDILVDVINASIGYNMTGSFNHLFLTNL---DTHL-------SGIDGFYSRDFTVAVAAV 267
            ::||.|:.|..::...:.....|...|..|.||   |..|       :.:.||...::|..:.|.
Mouse   201 VVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPAR 265

  Fly   268 RIRTYVPPPVHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNAL-------LEISQR--PGFYIP 323
            .::.:......|.     ..||.:.....|.|.||.:.:...|.       ::||:|  .|..:.
Mouse   266 IMQQWRTSDARDH-----TRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLA 325

  Fly   324 NFSCGRGFWQPGPRLVEQMKQITPKMVKPPFK--TQRLQINADGQREDFNLEVYNPIIDRVTHI- 385
            |.:..   |..|..:...::|:.       |:  |..:|.|..|:|.::.|.|.....|.:..| 
Mouse   326 NPAVP---WGQGIDIQRALQQVR-------FEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIG 380

  Fly   386 -WNKEFQLV----DFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVH 445
             ||::.:.|    |.:...:||:       :||:        .|.|.|.:..||...::...  .
Mouse   381 YWNEDDKFVPAATDAQAGGDNSS-------VQNR--------TYIVTTILEDPYVMLKKNAN--Q 428

  Fly   446 YEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDL 510
            :|||:|:|||.|:|...:|:...:.:..|.|.|.|||:.|.:|..|:|::.:|:...|.:.:..|
Mouse   429 FEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPL 493

  Fly   511 TITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTG 575
            |||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:.::.|.:..:..|....
Mouse   494 TITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVS 558

  Fly   576 RIDQYEWDQPVENVNREM---ERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFA 637
            |...|||........|:.   ::.|.:.:.|:||..||:.:.||||:.||.|..|::...||.|.
Mouse   559 RFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFT 623

  Fly   638 LLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKM 702
            |:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:|..:|..|........|..|
Mouse   624 LIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYM 688

  Fly   703 LSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQIGESFGEKHYGIAVPLN 766
            .|.:|..|.:..|||:.||:.|||.||:|:|:|..:|..||. |:..::|.:...|.||||.|..
Mouse   689 KSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKG 753

  Fly   767 ADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFD------MDSVGGLFVVL 825
            :..|..:::.:|:|||:|.|.||::||: .::..|.|.    |.|..|      :.:|.|:|.:|
Mouse   754 SALRGPVNLAVLKLSEQGVLDKLKSKWW-YDKGECGSK----DSGSKDKTSALSLSNVAGVFYIL 813

  Fly   826 IVGVVVGLVIGVAEFLWHVQRISVKEK 852
            |.|:.:.:::.:.||.:..:..|.:.|
Mouse   814 IGGLGLAMLVALIEFCYKSRSESKRMK 840

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
GluRIIBNP_523485.3 PBP1_iGluR_Kainate 26..393 CDD:107377 91/396 (23%)
ANF_receptor 41..378 CDD:279440 84/364 (23%)
PBP2_iGluR_Kainate 422..795 CDD:270432 134/376 (36%)
Lig_chan 555..822 CDD:278489 93/276 (34%)
Gria1NP_001106796.1 PBP1_iGluR_AMPA_GluR1 26..389 CDD:107385 91/396 (23%)
ANF_receptor 37..372 CDD:279440 84/368 (23%)
PBP2_iGluR_AMPA_GluR1 406..787 CDD:270447 135/391 (35%)
Glutamate binding. /evidence=ECO:0000250 492..494 0/1 (0%)
Lig_chan 538..817 CDD:278489 96/283 (34%)