Protein Alignment GluRIIB and GRIN3B

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_619635.1
• Gene: GRIN3B / 116444
• HGNCID: 16768
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 128/455 - (28%)
• Similarity: 189/455 - (41%)
• Gaps: 83/455 - (18%)

  Fly   454 GYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRS 518
            ||.:||:..||::..|||....|.|.|||:  .....|.|::..|:...|.:.:...:|..||..
Human   478 GYCIDLLERLAEDTPFDFELYLVGDGKYGA--LRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQ 540

  Fly   519 VVDFTVPFM--QLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYE 581
            |||||.||.  .|||.:.:.....|   |.||:.|.:...||.|..|:.:||..|..      ||
Human   541 VVDFTSPFFSTSLGIMVRARDTASP---IGAFMWPLHWSTWLGVFAALHLTALFLTV------YE 596

  Fly   582 WDQPVENVNREMERQNIWHLSNALWLVLGSMLNQ-------GCDLLPRGLPMRLLTAFWWIFALL 639
            |..|.....|...|..::..|:||.|....:..:       .|   |.|   |||...|.||.||
Human   597 WRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKC---PTG---RLLMNLWAIFCLL 655

  Fly   640 ISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQ---FGTIRGGATSVYFSESNDTDNRMAWNK 701
            :..:|.|.|||.:...|...::..:||....:..|   |||:...:...|..:|
Human   656 VLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIKKS----------- 709

  Fly   702 MLSFKPDAF-------TKNNEEGV-----DRVKLSKGTYAFLMETTNLQYYV--QRNCELTQIGE 752
                .||..       ......||     |..||:    ||:|:.:.|.|.|  ..:|:|..:|:
Human   710 ----FPDMHAHMRRHSAPTTPRGVAMLTSDPPKLN----AFIMDKSLLDYEVSIDADCKLLTVGK 766

  Fly   753 SFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDG-QFDMD 816
            .|..:.|||.:|.|:...||||..|.|....|.:..|.:||:..  ..|...|..:.:. |..:.
Human   767 PFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKM--VPCGKRVFAVTETLQMSIY 829

  Fly   817 SVGGLFVVLIVGVVVGLVIGVAE---FLWHVQRISVKEKIPPMLALKAEFYFVIRFWL-TRKPLH 877
            ...||||:|.:|:...|:..:.|   |...:.||....:              :::|| |.:.:|
Human   830 HFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKGSR--------------LQYWLHTSQKIH 880

  Fly   878  877
            Human   881  880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377
		ANF_receptor	41..378	CDD:279440
		PBP2_iGluR_Kainate	422..795	CDD:270432	110/366 (30%)
		Lig_chan	555..822	CDD:278489	78/291 (27%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	19..405	CDD:107372
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	109/365 (30%)
		Lig_chan	576..842	CDD:278489	82/298 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740