DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and Grik4

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	879	Identity:	253/879 - (28%)
Similarity:	415/879 - (47%)	Gaps:	82/879 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLL---ALAIASGANEDTLVIKIGAIFFD-TEMKLADAFSAALEEVNAINPA-LKLDAIKRYVT 66
            ||||   .|.:|...:.    ::|.||..| .|....:..|..|.: |.||.| .:|...|  |.
Mouse     8 LVLLPAWLLMVACSPHS----LRIAAILDDPMECSRGERLSITLAK-NRINRAPERLGKAK--VE 65

  Fly    67 VDDSIVLQD-------ISCDLIGSGVAAIFGPSSK-TNSDIVEVLCNMTGIPHLQFDWHPQQSNR 123
            ||...:|:|       ..|.::..||.|:.||||. .:|.|:..:|....:||  |...|::..|
Mouse    66 VDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPH--FKVAPEEFVR 128

  Fly   124 ERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKM 188
            .::....|:|:.|....:|.|.:.||  ..|:..:..:...::..|:.|:.:|....:.|..:.:
Mouse   129 FQLQRFTTLNLHPSNTDISVAVAGIL--NFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSV 191

  Fly   189 QEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGID 253
            :..:...|...|.|.|.:.:...:::...:.:...::..:....|..::.....|||:..|..:|
Mouse   192 RMLDDTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMD 256

  Fly   254 GFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRFS-----------SLGSQLVYDSIVLF 307
            ...  |..|.:....|..    ..|.....|..|::..:.           :|.|.|::|::...
Mouse   257 SLV--DDRVNILGFSIFN----QSHAFFQEFSQSLNQSWQENCDHVPFTGPALSSALLFDAVYAV 315

  Fly   308 YNALLEISQRPGFYIPNFSCGRG-FWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFN 371
            ..|:.|:::.....:...|||.. .||.|..|:..:     :||:....|..::.|:.|||.::.
Mouse   316 VTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYL-----RMVELEGLTGHIEFNSKGQRSNYA 375

  Fly   372 LEVYNPIIDRVTHIWNKEFQLVDFEKLRE-NSTQALKQKRLQNKEDFSQKPIRYT--VATRVGKP 433
            |::.             :|....|:::.: :..:.|.........:.|......|  |.|.:..|
Mouse   376 LKIL-------------QFTRNGFQQIGQWHVAEGLSMDSRLYASNISDSLFNTTLVVTTILENP 427

  Fly   434 YFSWREEPEGVH--YEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIR 496
            |...:    |.|  .|||:|:||:.||::..||:..:|::....|.|..||..:|| ..|.|::.
Mouse   428 YLMLK----GNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEAN-GTWTGMVG 487

  Fly   497 QLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVM 561
            :||...|.:.:..||||..|..|:||:.|||.||||||.......:...::||:|::..||||::
Mouse   488 ELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFML 552

  Fly   562 IAMMITAFALIFTGRIDQYEWDQPVENVNREME-RQNIWHLSNALWLVLGSMLNQGCDLLPRGLP 625
            :|.:..:..|....|:..|||..|......... ..|.:.|.|:||..:|..:.||..:.||.|.
Mouse   553 LAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALS 617

  Fly   626 MRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSES 690
            .|.::..||.|.|:|..:|.|.||||:|..::...|.|:.||.||..:::|||.||::..:|..|
Mouse   618 TRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNS 682

  Fly   691 NDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFG 755
            .....:..||.|.|.:|..|.|:.|||:.||..|  .||||:|:|..:||.||||.|||||....
Mouse   683 RYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS--NYAFLLESTMNEYYRQRNCNLTQIGGLLD 745

  Fly   756 EKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQ---FDMDS 817
            .|.|||.:|:.:.||....:.||:|.|...|..|:.||:...:  |    |..:|.:   ..|::
Mouse   746 TKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGK--C----PKEEDHRAKGLGMEN 804

  Fly   818 VGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKE 851
            :||:|||||.|::|.:.:.:.||||.::.....|
Mouse   805 IGGIFVVLICGLIVAIFMAMLEFLWTLRHSEASE 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	84/388 (22%)
		ANF_receptor	41..378	CDD:279440	78/357 (22%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	142/377 (38%)
		Lig_chan	555..822	CDD:278489	99/270 (37%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	86/412 (21%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	142/376 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846195
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850