Protein Alignment GluRIIB and grin3b

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_017952374.2
• Gene: grin3b / 100497172
• XenbaseID: XB-GENE-990106
• Length: 1005
• Species: Xenopus tropicalis
• Alignment Length: 907
• Identity: 202/907 - (22%)
• Similarity: 333/907 - (36%)
• Gaps: 224/907 - (24%)

  Fly    80 LIGSGVAAIFG-PSSKTNSDIVEVLCNMTGIP-------------------HLQFDWHPQQSNRE 124
            |:..|:||:.. |.::.....:|.|.:...||                   |||.|   .||:.|
 Frog    95 LVAQGIAAVLAFPQAQEELLQLEFLSSFLEIPFISILEQEQIVPLATKNPFHLQMD---TQSSVE 156

  Fly   125 RMNHQLTVNVAPMELFLS----AAFSDILASKTFDWKSFTIAYERSS------------HLIRLQ 173
            .:          |::|.|    :::.::.......|.|.:|....:|            |.:...
 Frog   157 NL----------MDIFFSVLQNSSWEEVDIITCHPWDSASIQRYLTSNTTLVSRTILNIHPVDES 211

  Fly   174 HILAWKQLHKAGIKMQEFER---GDDYR---ILWKRINNAREKFVLLDCPSDILVDVINASIGYN 232
            .::.:.|.|...:|..:|..   |.|.|   ::::         |..||  .:.....:..||:.
 Frog   212 ALVPFLQQHFESMKNPQFPMLLYGCDARRSSLVFR---------VARDC--GLEAHEFHWMIGHP 265

  Fly   233 MTG-------------SFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPP---VHDEI 281
            :.|             ::..:....::..:....|..:|..:.||       :|.|.   :...:
 Frog   266 LNGEEMTTEGMPPGLLAYGEVSRPTMEKFIRDAVGLVTRAISAAV-------HVRPDLALIQSMV 323

  Fly   282 DVFDNSVDTRFSSLGSQL---------------VYDSIVLFYNALLEISQ--------RPGFYIP 323
            :..|.......|| ||.|               :|.|     |.|:....        |.....|
 Frog   324 NCNDKQTKQNESS-GSYLSRFLANTSFSGQTGQIYVS-----NNLIHTEHHYRIWSLVRDSLGDP 382

  Fly   324 NFSCGRGF------------------WQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDF 370
            .:....|:                  |:|.|....:.|.....:|:.||...| :::|||
 Frog   383 TWVTVGGWRQGKMEVEEGLWQSRIQQWEPAPGGFARTKLRVVTLVEHPFVFTR-EVDADG----- 441

  Fly   371 NLEVYNPIIDRVTHIWNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYF 435
            :.......:|..|:  |.....|.||:|  ||..             ...|:.|....
 Frog   442 SCPAGQMCLDPRTN--NSAVLDVLFEEL--NSPN-------------GSVPLEYKTCC------- 482

  Fly   436 SWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLID 500
                             .||.:||:..|:::.:|||....|.|.|||:  ...|.|.|::..|:.
 Frog   483 -----------------YGYCIDLLEKLSEDLRFDFELYIVGDGKYGA--RKGDRWTGLVGDLLS 528

  Fly   501 NNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMM 565
            ..|.:.:...:|..||.:|:|||.||....:.|| .:.....:.|.||:.|.:..:|:.:.:|:.
 Frog   529 GAAHMAVTSFSINSARSTVIDFTSPFYSTSLGIL-VRMRDTASPIGAFMWPLHWSMWVGIFVALH 592

  Fly   566 ITAFALIFTGRIDQYEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQG-CDLLPRGLPMRLL 629
            |||..|.|      |||..|.........|..|:..|:||.|....:..:. ....|:....|:|
 Frog   593 ITALFLTF------YEWKSPFGMTPHGRNRTKIFSYSSALNLCYAILFGRTVSSKTPKCCTGRVL 651

  Fly   630 TAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQ---FGTIRGGATSVYFSESN 691
            ...|.||.||:..:|.|.|||.:...|....:..:||....:..|   |||:...:...|..:|.
 Frog   652 MNLWAIFCLLVLSSYTANLAAVMVGDKTFEALSGIHDPKLHHPSQGFRFGTVWESSAEQYIKKSF 716

  Fly   692 DTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTY-AFLMETTNLQYYV--QRNCELTQIGES 753
            ...:    |.|..|...|    ..:||..:|....|. ||:|:...|.|.|  ..:|:|..||:.
 Frog   717 PEMH----NYMRKFSVPA----TSDGVHLLKTDPPTLNAFIMDKALLDYEVSIDSDCKLLTIGKP 773

  Fly   754 FGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDG-QFDMDS 817
            |..:.|||.:|.|:...||:|..|.|....|.:..|.:||:..  ..|...|..:.:. |..:..
 Frog   774 FAIEGYGIGLPQNSPLTSNISEFISRYKSSGFMDTLHDKWYKM--VPCGKRVYAVTETLQMGIYH 836

  Fly   818 VGGLFVVLIVGVVVGLVIGVAE-FLWHVQRISVKEKIPPMLALKAEFYFVIRFWL-TRKPLH 877
            ..||||:|.:|....|:..:.| .::|:        |.|.:..:..|    ::|| |.:.:|
 Frog   837 FSGLFVLLCIGFCGSLLTSLMERVVYHL--------ILPRIRRRRRF----KYWLHTSQKIH 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	69/405 (17%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	106/379 (28%)
grin3b	XP_017952374.2	PBP1_iGluR_NMDA_NR3	29..402	CDD:380600	56/343 (16%)
		PBP2_iGluR_NMDA_Nr3	418..814	CDD:270438	123/459 (27%)
		Lig_chan	580..847	CDD:459656	80/282 (28%)