Protein Alignment GluRIIB and grik1

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_004912220.1
• Gene: grik1 / 100493949
• XenbaseID: XB-GENE-957124
• Length: 928
• Species: Xenopus tropicalis
• Alignment Length: 960
• Identity: 278/960 - (28%)
• Similarity: 468/960 - (48%)
• Gaps: 115/960 - (11%)

  Fly     4 LQFLVLLALAIASGANEDTLVIKIGAIFFDTEMKLAD----AFSAALEEVN-----AINPALKLD 59
            |.||..|| ||...|::.  |::||.||...|.:..:    ||..|:..:|     ..|..|..|
 Frog    27 LPFLCALA-AITPQASQQ--VLRIGGIFETVENEPINVEELAFKFAVTNINRNRTLMPNTTLTYD 88

  Fly    60 AIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDW-HPQQSNR 123
             |:| :.:.||......:||.:..||||:||||..::...|:.:||...:||:|..| ||...|:
 Frog    89 -IQR-INLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNK 151

  Fly   124 ERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKM 188
            :    ...:|:.|....:|.|..:::..  :.||:.|:.||.|:.|||||.::.....:...||:
 Frog   152 D----SFFINLHPDYAAISRAVLELVLH--YSWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKI 210

  Fly   189 QEFERGD-DYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGI 252
            ::...|: |.|.|.|.:..:||.:|:.||..:...:::...:...|...:.|.|.|.:|.....:
 Frog   211 RQLPSGNKDARTLLKEMKKSREFYVIFDCSHETAAEILKQILSMGMMTEYYHYFFTTMDLFALDL 275

  Fly   253 DGF-YSRDFTVAVAAVRI------------------RTYVPPPVHDEIDVFDNSVDTRFSSLGSQ 298
            :.: ||   .|.:...|:                  |...||  ..|..:.|..:.|     .:.
 Frog   276 EPYRYS---GVNMTGFRLLNIDNPQVSSVVEKWSMERLQAPP--KPETGLLDGMMTT-----DAA 330

  Fly   299 LVYDSIVLFYNALLEISQRPGFYIPNFSCGRGF-WQPGPRLVEQMKQITPKMVKPPFKTQRLQIN 362
            |:||::.:...|....:|   ..:.:..|.|.. |:.|||.:..:|:     .:....|.|:..|
 Frog   331 LMYDAVYMVAVATQRATQ---MTVSSLQCHRHKPWRFGPRFMSLIKE-----ARWDGLTGRITFN 387

  Fly   363 -ADGQREDFNLEVYNPIID--------RVTH---------IWNKEFQLVDFEKLRENSTQALKQK 409
             .||.|.||::::.:...|        .|.|         :||....|        |.|..||.|
 Frog   388 RTDGLRRDFDMDIISLKEDGMEKAAGETVNHLNKVWKKVGVWNSNTGL--------NMTDNLKDK 444

  Fly   410 RLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFE 474
            .....:..:.:.:  .|.|.:..||..:|:..:.::  ||:|||||.:||:..|:....|.:...
 Frog   445 STNITDSLANRTL--IVTTILEDPYVMFRKSDKPLY--GNDRFEGYCLDLLKELSNILGFTYEVR 505

  Fly   475 PVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEP 539
            .|.|.|||:.: :..||:|::|:|||:.|.:.:..||||..|..|:||:.|||.||||||..|..
 Frog   506 LVVDGKYGAQN-DKGEWNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPN 569

  Fly   540 PPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVE-NVNREMERQNIWHLSN 603
            .....:::||||.:.::|::|::|.:..:..|....|...|||..|.. |.:.::...| :.|.|
 Frog   570 GTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENN-FTLLN 633

  Fly   604 ALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLV 668
            :.|..:|:::.||.:|:|:.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||.
 Frog   634 SFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA 698

  Fly   669 DQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLME 733
            .|.|:::|.:|.|:|..:|.:|..:.....|..|.|.:..|..|||:||:.||..:  .||.|||
 Frog   699 KQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVKNNDEGIQRVLTT--DYALLME 761

  Fly   734 TTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNE 798
            :|:::|..||||.|||||.....|.||:..|:.:.:|..:::.||:|.|.|:|..::.||:..|
 Frog   762 STSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN- 825

  Fly   799 STCDSNVPTIDDGQ---FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALK 860
                 ..|..|..:   ..::::||:|:||..|:|:.:.:.:.||::..::.|..|:.....|:.
 Frog   826 -----GCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNSDIEQCLSFNAIM 885

  Fly   861 AEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSASSAKKKKKTRR 910
            .|....::        |..|..:...:.|.||   .||..:..:::..|:
 Frog   886 EELGISLK--------HPKRLKKKPKAKGRSS---FTSMLTCHQRRIIRK 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	101/409 (25%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	136/373 (36%)
grik1	XP_004912220.1	PBP1_iGluR_Kainate	46..439	CDD:380605	105/426 (25%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:473866	136/376 (36%)