DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and grik1

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_004912220.1	Gene:	grik1 / 100493949	XenbaseID:	XB-GENE-957124	Length:	928	Species:	Xenopus tropicalis

Alignment Length:	960	Identity:	278/960 - (28%)
Similarity:	468/960 - (48%)	Gaps:	115/960 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQFLVLLALAIASGANEDTLVIKIGAIFFDTEMKLAD----AFSAALEEVN-----AINPALKLD 59
            |.||..|| ||...|::.  |::||.||...|.:..:    ||..|:..:|     ..|..|..|
Frog    27 LPFLCALA-AITPQASQQ--VLRIGGIFETVENEPINVEELAFKFAVTNINRNRTLMPNTTLTYD 88

  Fly    60 AIKRYVTVDDSIVLQDISCDLIGSGVAAIFGPSSKTNSDIVEVLCNMTGIPHLQFDW-HPQQSNR 123
             |:| :.:.||......:||.:..||||:||||..::...|:.:||...:||:|..| ||...|:
Frog    89 -IQR-INLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNK 151

  Fly   124 ERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIKM 188
            :    ...:|:.|....:|.|..:::..  :.||:.|:.||.|:.|||||.::.....:...||:
Frog   152 D----SFFINLHPDYAAISRAVLELVLH--YSWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKI 210

  Fly   189 QEFERGD-DYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGI 252
            ::...|: |.|.|.|.:..:||.:|:.||..:...:::...:...|...:.|.|.|.:|.....:
Frog   211 RQLPSGNKDARTLLKEMKKSREFYVIFDCSHETAAEILKQILSMGMMTEYYHYFFTTMDLFALDL 275

  Fly   253 DGF-YSRDFTVAVAAVRI------------------RTYVPPPVHDEIDVFDNSVDTRFSSLGSQ 298
            :.: ||   .|.:...|:                  |...||  ..|..:.|..:.|     .:.
Frog   276 EPYRYS---GVNMTGFRLLNIDNPQVSSVVEKWSMERLQAPP--KPETGLLDGMMTT-----DAA 330

  Fly   299 LVYDSIVLFYNALLEISQRPGFYIPNFSCGRGF-WQPGPRLVEQMKQITPKMVKPPFKTQRLQIN 362
            |:||::.:...|....:|   ..:.:..|.|.. |:.|||.:..:|:     .:....|.|:..|
Frog   331 LMYDAVYMVAVATQRATQ---MTVSSLQCHRHKPWRFGPRFMSLIKE-----ARWDGLTGRITFN 387

  Fly   363 -ADGQREDFNLEVYNPIID--------RVTH---------IWNKEFQLVDFEKLRENSTQALKQK 409
             .||.|.||::::.:...|        .|.|         :||....|        |.|..||.|
Frog   388 RTDGLRRDFDMDIISLKEDGMEKAAGETVNHLNKVWKKVGVWNSNTGL--------NMTDNLKDK 444

  Fly   410 RLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFE 474
            .....:..:.:.:  .|.|.:..||..:|:..:.::  ||:|||||.:||:..|:....|.:...
Frog   445 STNITDSLANRTL--IVTTILEDPYVMFRKSDKPLY--GNDRFEGYCLDLLKELSNILGFTYEVR 505

  Fly   475 PVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEP 539
            .|.|.|||:.: :..||:|::|:|||:.|.:.:..||||..|..|:||:.|||.||||||..|..
Frog   506 LVVDGKYGAQN-DKGEWNGMVRELIDHKADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPN 569

  Fly   540 PPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVE-NVNREMERQNIWHLSN 603
            .....:::||||.:.::|::|::|.:..:..|....|...|||..|.. |.:.::...| :.|.|
Frog   570 GTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENN-FTLLN 633

  Fly   604 ALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLV 668
            :.|..:|:::.||.:|:|:.|..|::...||.|.|:|..:|.|.||||:|..::...|.|..||.
Frog   634 SFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA 698

  Fly   669 DQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLME 733
            .|.|:::|.:|.|:|..:|.:|..:.....|..|.|.:..|..|||:||:.||..:  .||.|||
Frog   699 KQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVKNNDEGIQRVLTT--DYALLME 761

  Fly   734 TTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNE 798
            :|:::|..||||.|||||.....|.||:..|:.:.:|..:::.||:|.|.|:|..::.||:..|
Frog   762 STSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGN- 825

  Fly   799 STCDSNVPTIDDGQ---FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALK 860
                 ..|..|..:   ..::::||:|:||..|:|:.:.:.:.||::..::.|..|:.....|:.
Frog   826 -----GCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNSDIEQCLSFNAIM 885

  Fly   861 AEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSASSAKKKKKTRR 910
            .|....::        |..|..:...:.|.||   .||..:..:::..|:
Frog   886 EELGISLK--------HPKRLKKKPKAKGRSS---FTSMLTCHQRRIIRK 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	103/415 (25%)
		ANF_receptor	41..378	CDD:279440	93/364 (26%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	136/373 (36%)
		Lig_chan	555..822	CDD:278489	90/270 (33%)
grik1	XP_004912220.1	Periplasmic_Binding_Protein_Type_1	43..438	CDD:299141	106/430 (25%)
		ANF_receptor	61..404	CDD:279440	93/368 (25%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:304360	136/376 (36%)
		Lig_chan	585..854	CDD:278489	93/277 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010