Protein Alignment GluRIIB and grik4

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_031761990.1
• Gene: grik4 / 100490768
• XenbaseID: XB-GENE-1011875
• Length: 962
• Species: Xenopus tropicalis
• Alignment Length: 907
• Identity: 249/907 - (27%)
• Similarity: 422/907 - (46%)
• Gaps: 137/907 - (15%)

  Fly     7 LVLLALAIASGANEDTLVIKIGAIFFD-TEMKLADAFSAALEEVNAINPA--------LKLDAIK 62
            ||||.|..::|:..    ::|.||..| .|....:..|..|.: |.||.|        |::|..:
 Frog    10 LVLLWLMKSAGSPS----LRIAAILDDPMECSRGERLSITLAK-NRINRAPERQGKARLEVDIFE 69

  Fly    63 RYVTVDDSIVLQDISCDLIGSGVAAIFGPS-SKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERM 126
              :..|......:..|.::..||..:.||| |.::|.|:..:|....:||::.      |..|.:
 Frog    70 --LLKDSEYETAETMCQILPKGVLGVLGPSYSPSSSSIISNICGEKEVPHIKV------STEEFL 126

  Fly   127 NHQ----LTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIK 187
            ..|    .|:|:.|....:|||.:.:|  :.|:..:..:...::..|:.|:.:|....:.|..:.
 Frog   127 RFQYQRFTTLNLHPSNTDISAAVATLL--RFFNSTTACLICAKAECLLNLEKLLRQFLISKDCLS 189

  Fly   188 MQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYN----------MTGSFNHLFL 242
            ::..:...|...|.|.|.:        |..|.|:|.. |||:.:.          :|..:.::|
 Frog   190 VRMLDDTWDPTPLLKEIRD--------DKTSTIIVHA-NASMSHTILMKAAELGMVTAYYTYIF- 244

  Fly   243 TNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVF----------------------- 284
            |||:..|...:.                     |:.|.:::.
 Frog   245 TNLEFVLQRFES---------------------PLDDRVNILGFSMFNQSHSYFKEFAHTLQQSW 288

  Fly   285 -DNSVDTRFS--SLGSQLVYDSIVLFYNALLEISQRPGFYIPNFSCGRG-FWQPGPRLVEQMKQI 345
             :|...:.|:  :|.:.|::|::....:|:.|:::.....:...|||.. .||.|..|:..:
 Frog   289 EENCDHSPFTGPALSAALLFDAVYGIVSAVQELNRSQEIGVKPLSCGSSQIWQHGTSLMNYL--- 350

  Fly   346 TPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLRE-NSTQALKQK 409
              :||:....|..::.|:.|||.::::::             .::....|:::.: :.|..|...
 Frog   351 --RMVELEGLTGHVEFNSKGQRSNYDMKI-------------MQYTKTGFQEIGQWHVTNGLNMD 400

  Fly   410 RLQNKEDFSQKPIRYT-VATRV-----GKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECK 468
            :.....:.|...:..| :.|.:     ..||...:...:  ..|||:|:||:.||::..||...:
 Frog   401 KRYFSPNASDTLVNKTLIVTTILFFLQENPYLMLKANHQ--ELEGNDRYEGFCVDMLKELAAILR 463

  Fly   469 FDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISI 533
            |::....|.|..||..:.| ..|.|::.:||...|.:.:..||||..|..|:||:.|||.|||||
 Frog   464 FNYKIRLVADGVYGVPELN-GTWTGMVGELISRKADLAVAGLTITAEREKVIDFSKPFMTLGISI 527

  Fly   534 LSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREME-RQN 597
            |.......|...::||:|::..||||:::|.:..:..|....|:..|||..|......... ..|
 Frog   528 LYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVN 592

  Fly   598 IWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIG 662
            .:.|.|:||..:|..:.||..:.||.|..|.::..||.|.|:|..:|.|.||||:|..::...|.
 Frog   593 QYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIE 657

  Fly   663 SLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGT 727
            |:.||.||..:::|||.||::..:|..|.....:..||.|.|.:|..|.|:.|||:.||..|  .
 Frog   658 SVDDLADQTTIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMHSKQPSVFVKSTEEGIARVLNS--N 720

  Fly   728 YAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNK 792
            ||||:|:|..:||.||||.|||:|.....|.|||.:|:.:.||....:.||:|.|...|..|:.|
 Frog   721 YAFLLESTMNEYYRQRNCNLTQVGGLLDTKGYGIGMPVGSAFRDEFDLAILQLQENNCLEDLKRK 785

  Fly   793 WFNSNESTCDSNVPTIDDGQ---FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKE 851
            |::..:  |    |..:|.:   ..|:::||:|||||.|::|.::|.:.||||.|:.....|
 Frog   786 WWDGGK--C----PKEEDHRAKGLGMENIGGIFVVLICGLIVAILIAMLEFLWTVRNAEDSE 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	81/411 (20%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	138/379 (36%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:471960	84/440 (19%)
		PBP2_iGluR_kainate_KA1	414..788	CDD:270442	138/378 (37%)