DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and grik4

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_031761990.1	Gene:	grik4 / 100490768	XenbaseID:	XB-GENE-1011875	Length:	962	Species:	Xenopus tropicalis

Alignment Length:	907	Identity:	249/907 - (27%)
Similarity:	422/907 - (46%)	Gaps:	137/907 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVLLALAIASGANEDTLVIKIGAIFFD-TEMKLADAFSAALEEVNAINPA--------LKLDAIK 62
            ||||.|..::|:..    ::|.||..| .|....:..|..|.: |.||.|        |::|..:
Frog    10 LVLLWLMKSAGSPS----LRIAAILDDPMECSRGERLSITLAK-NRINRAPERQGKARLEVDIFE 69

  Fly    63 RYVTVDDSIVLQDISCDLIGSGVAAIFGPS-SKTNSDIVEVLCNMTGIPHLQFDWHPQQSNRERM 126
              :..|......:..|.::..||..:.||| |.::|.|:..:|....:||::.      |..|.:
Frog    70 --LLKDSEYETAETMCQILPKGVLGVLGPSYSPSSSSIISNICGEKEVPHIKV------STEEFL 126

  Fly   127 NHQ----LTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHKAGIK 187
            ..|    .|:|:.|....:|||.:.:|  :.|:..:..:...::..|:.|:.:|....:.|..:.
Frog   127 RFQYQRFTTLNLHPSNTDISAAVATLL--RFFNSTTACLICAKAECLLNLEKLLRQFLISKDCLS 189

  Fly   188 MQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYN----------MTGSFNHLFL 242
            ::..:...|...|.|.|.:        |..|.|:|.. |||:.:.          :|..:.::|
Frog   190 VRMLDDTWDPTPLLKEIRD--------DKTSTIIVHA-NASMSHTILMKAAELGMVTAYYTYIF- 244

  Fly   243 TNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVF----------------------- 284
            |||:..|...:.                     |:.|.:::.
Frog   245 TNLEFVLQRFES---------------------PLDDRVNILGFSMFNQSHSYFKEFAHTLQQSW 288

  Fly   285 -DNSVDTRFS--SLGSQLVYDSIVLFYNALLEISQRPGFYIPNFSCGRG-FWQPGPRLVEQMKQI 345
             :|...:.|:  :|.:.|::|::....:|:.|:::.....:...|||.. .||.|..|:..:
Frog   289 EENCDHSPFTGPALSAALLFDAVYGIVSAVQELNRSQEIGVKPLSCGSSQIWQHGTSLMNYL--- 350

  Fly   346 TPKMVKPPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLRE-NSTQALKQK 409
              :||:....|..::.|:.|||.::::::             .::....|:::.: :.|..|...
Frog   351 --RMVELEGLTGHVEFNSKGQRSNYDMKI-------------MQYTKTGFQEIGQWHVTNGLNMD 400

  Fly   410 RLQNKEDFSQKPIRYT-VATRV-----GKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECK 468
            :.....:.|...:..| :.|.:     ..||...:...:  ..|||:|:||:.||::..||...:
Frog   401 KRYFSPNASDTLVNKTLIVTTILFFLQENPYLMLKANHQ--ELEGNDRYEGFCVDMLKELAAILR 463

  Fly   469 FDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISI 533
            |::....|.|..||..:.| ..|.|::.:||...|.:.:..||||..|..|:||:.|||.|||||
Frog   464 FNYKIRLVADGVYGVPELN-GTWTGMVGELISRKADLAVAGLTITAEREKVIDFSKPFMTLGISI 527

  Fly   534 LSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVENVNREME-RQN 597
            |.......|...::||:|::..||||:::|.:..:..|....|:..|||..|......... ..|
Frog   528 LYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVN 592

  Fly   598 IWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIG 662
            .:.|.|:||..:|..:.||..:.||.|..|.::..||.|.|:|..:|.|.||||:|..::...|.
Frog   593 QYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIE 657

  Fly   663 SLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGT 727
            |:.||.||..:::|||.||::..:|..|.....:..||.|.|.:|..|.|:.|||:.||..|  .
Frog   658 SVDDLADQTTIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMHSKQPSVFVKSTEEGIARVLNS--N 720

  Fly   728 YAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNK 792
            ||||:|:|..:||.||||.|||:|.....|.|||.:|:.:.||....:.||:|.|...|..|:.|
Frog   721 YAFLLESTMNEYYRQRNCNLTQVGGLLDTKGYGIGMPVGSAFRDEFDLAILQLQENNCLEDLKRK 785

  Fly   793 WFNSNESTCDSNVPTIDDGQ---FDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKE 851
            |::..:  |    |..:|.:   ..|:::||:|||||.|::|.::|.:.||||.|:.....|
Frog   786 WWDGGK--C----PKEEDHRAKGLGMENIGGIFVVLICGLIVAILIAMLEFLWTVRNAEDSE 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	81/417 (19%)
		ANF_receptor	41..378	CDD:279440	76/386 (20%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	138/379 (36%)
		Lig_chan	555..822	CDD:278489	98/270 (36%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:415822	84/440 (19%)
grik4	XP_031761990.1	PBP2_iGluR_kainate_KA1	414..788	CDD:270442	138/378 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010