Protein Alignment GluRIIB and grin2b

DIOPT Version :10

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 931
• Identity: 198/931 - (21%)
• Similarity: 373/931 - (40%)
• Gaps: 219/931 - (23%)

  Fly    19 NEDTLVIKIGAIFFDTEMKLADAFSAALEEVN--------AINPALKLDAIKRYVTVDDSIVLQD 75
            |.|..||.:|.    |:       ..|:::|:        .:.|.:.|      ||:::|.....
 Frog    29 NMDIAVILVGT----TD-------EVAIKDVHEKDDFHHLPVTPRVAL------VTMNESDPKSI 76

  Fly    76 IS--CDLIG----SGVAAIFGPSSKTNS-----DIVEV--LCNMTGI-------------PHLQF 114
            |:  |||:.    .||  :||..:...:     |.:.|  |..:.||             ..:.|
 Frog    77 ITRICDLMSDKKVQGV--VFGDDTDQEAIAQILDFISVQTLTPILGIHGGSSMIMADKEEASMFF 139

  Fly   115 DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTI------AYERSSHLIRL- 172
            .:.|.      :..|.:|.:..||              .:||..|:|      .|:...:.:|.
 Frog   140 QFGPS------IEQQASVMLNIME--------------EYDWYIFSIVTTYFPGYQDFENKVRST 184

  Fly   173 --QHILAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTG 235
              ...:.|:......:.|   ...|:...:..::...:...:||.|..:....:...:....:||
 Frog   185 IENSFVGWELEEVIHLDM---SLDDNDSKIQNQLKKLQSPVILLYCTKEEATYIFEVAHSVGLTG 246

  Fly   236 SFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTY---VPPPVHDEIDVFDNSVDTRFS---- 293
             :.:.::  :.:.::|.......:|...:.:|....:   :|..|.|.|.:...:..|..|
 Frog   247 -YGYTWI--VPSLVAGDTDTVPAEFPTGLISVSYDEWDYDLPARVRDGIAIITTAASTMLSEHNS 308

  Fly   294 ---------SLGSQLVYDSIVLFYNALLEISQRPGFYIPNFSCGRGFWQPGPRLV---------- 339
                     ::....||::.:| ...|:.::    |...|.|.....:|..|:||
 Frog   309 IPQSKSSCYNIQESRVYEAHML-KRYLINVT----FEGRNLSFSEDGYQMHPKLVIILLNQQRKW 368

  Fly   340 EQMKQITPKMVK------PPFKTQRLQINADGQREDFNLEVYNPIIDRVTHIWNKEFQLV-DFEK 397
            |::.:...:.:|      |.|:   |..|:: :.:|.:|.:       || :....|.:| |.:.
 Frog   369 ERVGKYKDRSLKMKYYVWPVFE---LYPNSE-EHKDEHLSI-------VT-LEEAPFVIVEDVDP 421

  Fly   398 L----RENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVD 458
            |    ..|:....||.|.:|:.:                         ||.:|. ....:|:.:|
 Frog   422 LSGTCMRNTVPCRKQIRTENRTE-------------------------EGGNYI-KRCCKGFCID 460

  Fly   459 LIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFT 523
            ::..:|:..||.::...|.:.|:|.....|  |:|:|.:::...|.:.:..|||.:.|..||||:
 Frog   461 ILKKIAKTVKFTYDLYLVTNGKHGKKINGT--WNGMIGEVVTKRAYMAVGSLTINEERSEVVDFS 523

  Fly   524 VPFMQLGISIL---SYKEPPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQP 585
            |||::.|||::   |.....|.    |||.|::|:||:.:.:.::|.:...:|.     :|:..|
 Frog   524 VPFIETGISVMVSRSNGTVSPS----AFLEPFSADVWVMMFVMLLIVSAVAVFV-----FEYFSP 579

  Fly   586 VENVNREMERQN-----IWHLSNALWLVLGSMLNQGCDLL-PRGLPMRLLTAFWWIFALLISQTY 644
            | ..||.:....     .:.:..|:||:.|.:.|....:. |:|...:::.:.|..||::...:|
 Frog   580 V-GYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASY 643

  Fly   645 IAKLAAFITSSKIAGDIGSLHDLVDQN------KVQFGTIRGGATSVYFSESNDTDNRMAWNKML 703
            .|.||||:...:....:..|.|...|.      ..:|||:..|:|     |.|..:|.:   :|.
 Frog   644 TANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGST-----ERNIRNNYL---EMH 700

  Fly   704 SFKPDAFTKNNEEGVDRVKLSKGT---YAFLMETTNLQYYVQRN--CELTQIGES--FGEKHYGI 761
            |:    ..|.|:..|....||..|   .||:.:...|.|...|:  |:|..||..  |....|||
 Frog   701 SY----MVKFNQRSVQDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGI 761

  Fly   762 AVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLI 826
            |:..::.::..:.:.||:|...||:.:|...|..   ..|.:....:...|.|:|::.|:|.:|.
 Frog   762 AIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT---GICHNEKNEVMSSQLDIDNMAGVFYMLA 823

  Fly   827 VGVVVGLVIGVAE--FLWHVQ 845
            ..:.:.|:..:.|  |.|.::
 Frog   824 AAMALSLITFIMEHLFFWQLR 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..387	CDD:380605	72/435 (17%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	102/394 (26%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	68/403 (17%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	116/460 (25%)
		NMDAR2_C	837..1449	CDD:463148	2/8 (25%)