Protein Alignment GluRIIB and grin2cb

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_009305071.2
• Gene: grin2cb / 100333648
• ZFINID: ZDB-GENE-100308-2
• Length: 1328
• Species: Danio rerio
• Alignment Length: 908
• Identity: 199/908 - (21%)
• Similarity: 355/908 - (39%)
• Gaps: 204/908 - (22%)

  Fly    49 VNAINPALKLDAIKRYVTVDD--SIVLQDISCDLIGSGVAAIFG-PSSKTNSDIVEVLCNMTG-- 108
            ||..||...|..:.:.:..:.  .:|.:|   |:....||.|.. .||:|:..||    .::|
Zfish    77 VNDTNPRALLTRLCQTMAAESLHGVVFED---DVDSEAVAQILDFVSSQTSIPIV----GISGGS 134

  Fly   109 ---IPH-------LQFDWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTI-- 161
               |||       ||..                   |.::..::|.|.   ..:.::|.:|.:
Zfish   135 AVVIPHKADGSTFLQMG-------------------ASIDQQINAMFK---VMEEYNWGNFVVIT 177

  Fly   162 ----AYERSSHLIR-----------LQHILAWKQLHKAGIKMQEFERGDDYRILWKRINNAREKF 211
                .||.....||           ||.:|:::....|                    |:.|.:.
Zfish   178 SLYPGYETFVDYIRSFTDTSYFLWELQDVLSFEMSVGA--------------------NDIRTRR 222

  Fly   212 VLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPP 276
            :|....|.:.       :.|.......:||....|..|.| .|:.....::||.    .....||
Zfish   223 LLQQVDSQVY-------LVYCSHEEAQYLFRMASDVGLLG-PGYIWIVPSLAVG----NPEAAPP 275

  Fly   277 VHDEIDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEISQRPGFYIP--NFSCGRGFWQPGPRLV 339
            ....:.|.....| |:.....|.|.:.:.:....:....:..|| ||  :..|.      .|...
Zfish   276 ASFPVGVISIITD-RWRKTLRQRVREGVAIIVKGVHSFHKHRGF-IPEGHSDCS------SPVKS 332

  Fly   340 EQMKQITPKMVKPPFKTQRLQINADGQREDFNLEVYNP-----IIDRVTHIWNK----EFQLVD- 394
            .....:...|:...::.:.|..|:||.       :.||     .:||..| |:|    |..::.
Zfish   333 YANNSLFRHMLNVSWEHKDLSFNSDGY-------LTNPSMVIIALDRENH-WDKVGSYEGGILQM 389

  Fly   395 -----------FEKLRENS--TQALKQKR----LQNKEDFSQKPIRYTVATRVGKPYFSWREEPE 442
                       .|.:.:|.  |.|..::|    :::.:..:...:|.||..|    ..|.|.|..
Zfish   390 RYPVWPRYGSFLEPVSDNRHLTVATLEERPFVIVESVDPATGTCVRNTVPCR----RQSNRTESI 450

  Fly   443 GVHYEGNERF--EGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQI 505
            ..|.|...:.  :|:.:|::..|::..||.::...|.:.|:|......  |:|:|.::....|.:
Zfish   451 IGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHGKMVRGV--WNGMIGEVFYKRADM 513

  Fly   506 GICDLTITQARRSVVDFTVPFMQLGISIL---SYKEPPPKADIYAFLNPYNAEVWLFVMIAMMIT 567
            .|..|||.:.|..:|||:|||::.|||::   |.....|.    |||.||:..||: :|..|.:|
Zfish   514 AIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS----AFLEPYSPAVWV-MMFVMCLT 573

  Fly   568 AFAL-IFTGRIDQYEWDQPVENVNREMERQN-----IWHLSNALWLVLGSMLNQGCDL-LPRGLP 625
            ..|: :|.     :|:..|| ..||.:....     .:.:..::||:.|.:.|....: .|:|..
Zfish   574 VVAVTVFV-----FEYFSPV-GYNRSLVSAKAPGGPTFTIGKSVWLLWGIVFNNSVPIENPKGTT 632

  Fly   626 MRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQN------KVQFGTIRGGATS 684
            .:::...|..||::...:|.|.||||:...:....:..|.|...|.      ..:|||:..|:|
Zfish   633 SKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEHYPPFRFGTVPNGST- 696

  Fly   685 VYFSESNDTDNRMAWNKMLSFKPDAFT---KNNEEGVDRV--KLSKGTY-AFLMETTNLQYYVQR 743
                |.|...|          .||..|   |.|::||:..  .|..|.. ||:.:...|.|...:
Zfish   697 ----ERNIRSN----------YPDMHTHMIKYNQKGVEEALNSLKTGKLDAFIYDAAVLNYMAGK 747

  Fly   744 N--CELTQIGES--FGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSN 804
            :  |:|..||..  |....||||:..::.::..:.:.:|:....|:..:|...|.:   ..|.:.
Zfish   748 DEGCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWLS---GICQNE 809

  Fly   805 VPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFL--WHVQR-ISVKEKIPPMLALKAEFY 864
            ...:...:.|:|::.|:|.:|:|.:.:.|::...|.|  |.::. :...:::..:||:....|
Zfish   810 KNEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWKLRHSVHKSDRLDFLLAISRGIY 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	74/386 (19%)
		ANF_receptor	41..378	CDD:279440	68/367 (19%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	106/400 (27%)
		Lig_chan	555..822	CDD:278489	68/289 (24%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	74/395 (19%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	111/435 (26%)
		NMDAR2_C	845..>932	CDD:313729	5/28 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591062
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830