DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIB and LOC100331381

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_017207884.1	Gene:	LOC100331381 / 100331381	-ID:	-	Length:	1063	Species:	Danio rerio

Alignment Length:	948	Identity:	257/948 - (27%)
Similarity:	456/948 - (48%)	Gaps:	106/948 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHGLQFLVLLALAIASGANEDTL-VIKIGAIFFDTEM-----KLADAFSAALEEVNAI--NPA-- 55
            :|.|..::||.:|.:|.:....| .:::.||..|...     :|  |.:.|.|.:|::  .||
Zfish    11 IHLLFLVLLLTMAPSSHSQVPALSAVRMAAILDDQSACGRGERL--ALALARENINSLMEGPARA 73

  Fly    56 -LKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIFGP-SSKTNSDIVEVLCNMTGIPHLQFDWHP 118
             :::|..:  :..|......|..|.::..||.::.|| ||..:...|..:|....|||::..  |
Zfish    74 RVEVDIFE--LQRDSQYETTDTMCQILPKGVVSVIGPASSPASGSTVSHICGEKEIPHIKIG--P 134

  Fly   119 QQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIAYERSSHLIRLQHILAWKQLHK 183
            :::.|.......:|.:.|....||.|...||  ::|.:.:.::...::..|:||:.::....:.:
Zfish   135 EETPRLPYLRFASVTLYPSNEDLSLAIGAIL--RSFGYPTASLICAKAECLLRLEELVRHFLISR 197

  Fly   184 AGIKMQEFERGDDYRILWKRINNAREKFVLLDCPSDILVDVINASIGYNMTGSFNHLFLTNLDTH 248
            ..:.::..:...|...|.|.|.:.:...:::|..:.:.:.::..:....||.:|....||.:|..
Zfish   198 ETLSVRMLDENLDPTPLLKEIRDDKVATIIIDANASVSILILKKASELGMTSAFYKYILTTMDFP 262

  Fly   249 LSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDEIDVFDNSVDTRF-----------SSLGSQLVYD 302
            |..:|...:....:...::...::   |.:.|   |..|::..:           .:|.|.|::|
Zfish   263 LLRLDDVVNDQSNIVGFSMLNNSH---PFYLE---FIRSLNLSWREGCDLSPYPGPALSSALMFD 321

  Fly   303 SIVLFYNALLEISQRPGFYIPNFSCGRG-FWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQ 366
            ::.:...|:.|:::.....:...||... .||.|..|:..:     :||:....|.|::.|:.||
Zfish   322 AVHVVVGAVRELNRSQEIGVKPLSCTSSLIWQHGTSLMNYL-----RMVEYDGLTGRVEFNSKGQ 381

  Fly   367 REDFNLEVYNPIIDRVTHIWNKEFQLVDFEKLR----------ENSTQALKQKRL--QNKEDFSQ 419
            |.::.|.:                    .||.:          .|:|.|:....|  ...|..:.
Zfish   382 RTNYTLRI--------------------LEKFKGGHKEIGVWYSNNTLAMNSTSLDINTSETLAN 426

  Fly   420 KPIRYTVATRVGKPYFSWREEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSY 484
            |.:  ||.|.:..||...:|..:  .::|::::||:.||::..||...||.|..:.|.|..||:.
Zfish   427 KTL--TVTTILENPYVMRKENYQ--DFQGSDQYEGFCVDMLRELADILKFSFRIKLVDDGLYGAP 487

  Fly   485 DANTDEWDGIIRQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFL 549
            :.| ..|.|::.:||:..|.:.:...|||..|..|:||:.|||.||||||.......|...::||
Zfish   488 EPN-GSWTGMVGELINRKADLAVAGFTITSEREKVIDFSKPFMNLGISILYRVHIGRKPGYFSFL 551

  Fly   550 NPYNAEVWLFVMIAMMITAFALIFTGRIDQYEWDQPVE--NVNREMERQNIWHLSNALWLVLGSM 612
            :|::..||||:::|.:..:..|....|:..|||..|..  ...|:: .:|.:.|.|:||..:|..
Zfish   552 DPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPFPCWRERRDL-LENQYTLGNSLWFPIGGF 615

  Fly   613 LNQGCDLLPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGT 677
            :.||.:::||.|..|.::..||.|.|:|..:|.|.||||:|..::...|.|..||.||..:|:||
Zfish   616 MQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESAEDLADQTNIQYGT 680

  Fly   678 IRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQ 742
            |:||:|..:|..|.....:..||.|.|.:|..|.|:.|||:.||..||  ||||:|:|..:|:.:
Zfish   681 IQGGSTMTFFMNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSK--YAFLLESTMNEYHRR 743

  Fly   743 RNCELTQIGESFGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPT 807
            .||.|||||.....|.|||.:||.:.||..:::|||:|.|...|..|:.:|:...:...:.:...
Zfish   744 LNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLGILQLQENNRLEILKRRWWEGGKCLKEEDHRA 808

  Fly   808 IDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEKIPPMLALKAEFYFVIRFWLT 872
            ...|   ||::||:|||||.|:::.:.:.:.||:|..:|.:..:::.|...
Zfish   809 KGLG---MDNIGGIFVVLICGLIIAVFVAIMEFVWSTRRSAETDEVRPHPC-------------- 856

  Fly   873 RKPLHTYRQSRDSTSTGYSSLEQITSASSAKKKKKTRR 910
              |:..:|.:|  .|.....:.:..:..|.||..:.||
Zfish   857 --PVRNHRHAR--VSVCQEMMTEFRNVISCKKNSRLRR 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	76/389 (20%)
		ANF_receptor	41..378	CDD:279440	72/354 (20%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	141/374 (38%)
		Lig_chan	555..822	CDD:278489	100/268 (37%)
LOC100331381	XP_017207884.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920