DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIB and si:dkey-183j2.10

DIOPT Version :9

Sequence 1:	NP_523485.3	Gene:	GluRIIB / 33789	FlyBaseID:	FBgn0020429	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_001923977.1	Gene:	si:dkey-183j2.10 / 100151589	ZFINID:	ZDB-GENE-130530-729	Length:	465	Species:	Danio rerio

Alignment Length:	434	Identity:	138/434 - (31%)
Similarity:	225/434 - (51%)	Gaps:	18/434 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 RFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNNAQIGICDLTITQA 515
            :.|||.:||:..||::..|.:....|:|..||..|.| ..|:|:|.:::...|.:.:..||:|.|
Zfish    48 QLEGYCMDLLTELAKKLGFKYKVHLVKDGSYGRQDEN-GNWNGMIGEVVRGEADLAVAPLTLTAA 111

  Fly   516 RRSVVDFTVPFMQLGISILSYKE-PPPKADIYAFLNPYNAEVWLFVMIAMMITAFALIFTGRIDQ 579
            |...|..|.|:||.|||||..|: ...:|..:.||:|::.|.|..::||..:||..:...||:..
Zfish   112 REKAVGMTKPYMQTGISILLRKDIVSEEAGFFDFLSPFSGETWFGILIAYFVTAVCICIVGRLSP 176

  Fly   580 YEWDQPVENVNREMERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLLTAFWWIFALLISQTY 644
            .||.||      |.| .|.:.|.::||...|::..||....|:.:..|:::..||:||:::...|
Zfish   177 CEWSQP------ETE-PNHFTLLHSLWYTAGALSLQGAGPHPKAVSGRVISCTWWLFAVVLLACY 234

  Fly   645 IAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDA 709
            .:.|::...|......|....||.:|:.:::||:.|.:|..:|..||:...|..:..|...|  :
Zfish   235 FSSLSSTQGSDSAPLMIKGFEDLANQDVIEYGTLAGSSTLAFFKNSNNPSYRRIYEHMERRK--S 297

  Fly   710 FTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRNCELTQIGESFGEKHYGIAVPLNADFRSNLS 774
            |..:.:|||.:.|  :|.|||:.|:.:|...|.|:|||.:..|..|.:.|.|..||.:....|||
Zfish   298 FVSSMDEGVQKAK--EGNYAFIGESVSLDLAVARHCELVRAHEVIGMRGYSIVTPLGSAMLKNLS 360

  Fly   775 VGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAE 839
            |.||:|||.|||..||.||:.|  |....|...   ......|:.|:|:||.:|:.:|:::.:.|
Zfish   361 VAILQLSEAGELAYLRTKWWAS--SCLPDNAKA---SSLRAHSMKGIFLVLAIGLGIGVLLSLFE 420

  Fly   840 FLWHVQRISVKEKIPPMLALKAEFYFVIRFWLTRKPLHTYRQSR 883
            .....:..:.::|......|..|....:|...|::...|..:|:
Zfish   421 LTTKSRSAAGEQKKSCCTVLTQELSQRLRMTNTKRDQDTSDKSK 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377
		ANF_receptor	41..378	CDD:279440
		PBP2_iGluR_Kainate	422..795	CDD:270432	120/344 (35%)
		Lig_chan	555..822	CDD:278489	87/266 (33%)
si:dkey-183j2.10	XP_001923977.1	PBP2_iGluR_non_NMDA_like	28..381	CDD:270403	120/344 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.770