Protein Alignment GluRIIB and gria1

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_004912781.1
• Gene: gria1 / 100127569
• XenbaseID: XB-GENE-995621
• Length: 903
• Species: Xenopus tropicalis
• Alignment Length: 880
• Identity: 254/880 - (28%)
• Similarity: 414/880 - (47%)
• Gaps: 115/880 - (13%)

  Fly    25 IKIGAIFFDTEMKLADAFSAALEEVNAINPALKLDAIKRYVTVDDSIVLQDISCDLIGSGVAAIF 89
            |:||.:|.:.:.:...||..||.:::  .|...|..|. .|.:.||..:....|.....||.|||
 Frog    25 IQIGGLFPNQQSQEHAAFRFALSQLS--EPPKLLPQID-IVNISDSFEMTYTFCSQFSKGVYAIF 86

  Fly    90 G-PSSKTNSDIVEVLCNMTGIPHLQF---DWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILA 150
            | ...||    |.:|.:..|..|:.|   .:....||      |..:.:.| ||      .|.|.
 Frog    87 GFYDRKT----VNMLTSFCGALHVCFITPSFPVATSN------QFVLQLRP-EL------QDALI 134

  Fly   151 S--KTFDWKSFTIAYERSSHLIRLQHIL---AWKQLHKAGIK-MQEFERGDDYRILWKRINNARE 209
            |  :.:.||.|...|:....|..||.:|   |.|......:. :...|.|  ||:|::.::.:::
 Frog   135 SVIEYYKWKKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEG--YRLLFQDLDKSKD 197

  Fly   210 KFVLLDCPSD----ILVDVI----NASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRD---FTVA 263
            :.:::||.|:    ||..|:    ...|||       |..|.||        ||...|   |..|
 Frog   198 RQIVIDCESERLNAILTQVVVKLEKNIIGY-------HYILANL--------GFMDIDMQKFKEA 247

  Fly   264 ---VAAVRIRTYVPPPVHDEIDVFDN-------SVDTRFSSLGSQLVYDSIVLFYNAL------- 311
               |...::..|....|...:..:.|       .||.:.....|.|.||.:.:...|.
 Frog   248 GANVTGFQLVNYTDTMVSRIMQQWKNYDGREQPRVDWKKPKYTSALTYDGVRVMAEAFQSLRKQR 312

  Fly   312 LEISQR--PGFYIPNFSCGRGFWQPGPRLVEQMKQITPKMVKPPFKTQRLQINADGQREDFNLEV 374
            ::||:|  .|..:.|.:..   |..|..:...::|:..:.:     :..:|.|..|:|.::.|.|
 Frog   313 IDISRRGNAGDCLANPAVP---WGQGIDIQRALQQVRLEGL-----SGNVQFNEKGRRTNYTLHV 369

  Fly   375 YNPIIDRVTHI--WNKEFQLVDFEKLRENSTQALKQKRLQNKEDFSQKPIRYTVATRVGKPYFSW 437
            .....:.:.||  ||::.:|:......:.....:   .:||:        .|.|.|.:..||...
 Frog   370 LELKHEGIRHIAHWNEDDKLIPLATDAQAGNDTI---GVQNR--------TYIVTTILEAPYVML 423

  Fly   438 REEPEGVHYEGNERFEGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGIIRQLIDNN 502
            ::..:  ..|||:|||||.|:|...:|:...|.:..|.|:|.|||:.|::...|:|::.:|:...
 Frog   424 KKNAD--QLEGNDRFEGYCVELAAEIAKHVGFKYKLEIVKDGKYGARDSDMKAWNGMVGELVYGR 486

  Fly   503 AQIGICDLTITQARRSVVDFTVPFMQLGISILSYKEPPPKADIYAFLNPYNAEVWLFVMIAMMIT 567
            |.:.:..||||..|..|:||:.|||.|||||:..|....|..:::||:|...|:|:.::.|.:..
 Frog   487 ADLAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGV 551

  Fly   568 AFALIFTGRIDQYEWDQPVENVNREM---ERQNIWHLSNALWLVLGSMLNQGCDLLPRGLPMRLL 629
            :..|....|...|||........:|.   ::.|.:.:.|:||..||:.:.||||:.||.|..|::
 Frog   552 SVVLFLVSRFSPYEWHNEEFEEGKEQPTTDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIV 616

  Fly   630 TAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQNKVQFGTIRGGATSVYFSESNDTD 694
            ...||.|.|:|..:|.|.||||:|..::...|.|..||..|.::.:||:..|:|..:|..|....
 Frog   617 GGVWWFFTLIIISSYTANLAAFLTVERMVSPIESADDLAKQTEIAYGTLDSGSTKEFFKRSKIAV 681

  Fly   695 NRMAWNKMLSFKPDAFTKNNEEGVDRVKLSKGTYAFLMETTNLQYYVQRN-CELTQIGESFGEKH 758
            ....|..|.|.:|..|.|..|||::||:.|||.||:|:|:|..:|..||. |:..::|.:...|.
 Frog   682 FEKMWTYMRSAEPSVFVKTTEEGMNRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKG 746

  Fly   759 YGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSNESTCDSNVPTIDDGQFD------MDS 817
            ||||.|..:..|..:::.:|:|||:|.|.||::||: .::..|.|.    |.|..|      :.:
 Frog   747 YGIATPKGSPLRGAVNLAVLKLSEQGVLDKLKSKWW-YDKGECGSK----DSGSKDKTSALSLSN 806

  Fly   818 VGGLFVVLIVGVVVGLVIGVAEFLWHVQRISVKEK 852
            |.|:|.:||.|:.:.:::.:.||.:..:..|.|.|
 Frog   807 VAGVFYILIGGLGLAMLVALIEFCYKSRSESKKMK 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	98/408 (24%)
		ANF_receptor	41..378	CDD:279440	91/376 (24%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	136/376 (36%)
		Lig_chan	555..822	CDD:278489	94/276 (34%)
gria1	XP_004912781.1	PBP1_iGluR_AMPA_GluR1	26..393	CDD:380613	99/411 (24%)
		PBP2_iGluR_AMPA_GluR1	407..788	CDD:270447	137/391 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000