Protein Alignment GluRIIB and grin2ca

DIOPT Version :9

• Sequence 1: NP_523485.3
• Gene: GluRIIB / 33789
• FlyBaseID: FBgn0020429
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 1029
• Identity: 218/1029 - (21%)
• Similarity: 389/1029 - (37%)
• Gaps: 248/1029 - (24%)

  Fly     8 VLLALAIAS---------GANEDTLVIKIGAIF----FDTEMKLADAFSAALEEVNAINPALKLD 59
            |||.|::.|         |..|.|  :.:..:|    :.||:|      ..|...|.::..|:::
Zfish    16 VLLLLSVCSVPCCQCRPFGMVEPT--VNVAVVFSGSAYQTEIK------GRLSRENFLDLPLEVN 72

  Fly    60 AIKRYVTVDDSIVLQDISCDLIGS----GVAAIFGPSSKTNSDIVEVLCNMTGIP---------- 110
            .|...|...:...|....||.:.:    ||.......|:..:.|::.:...|.:|
Zfish    73 PITVLVNNTNPRTLLTRICDTLAANRVHGVVFEDNIGSEAVAQILDFISTQTAVPIVGISGGSAV 137

  Fly   111 ----------HLQFDWHPQQSNRERMNHQLTVNVAPMELFLSAAFSDILASKTFDWKSFTIA--- 162
                      .||..    .|..:::|....|    ||              .::|.||.:.
Zfish   138 VLPHKGDGSTFLQLG----SSIEQQINGMFKV----ME--------------EYNWDSFVVVTSL 180

  Fly   163 ---------YERSSHLIRLQHILAWKQLHKAGIKMQE---FERGDDYRILWKRINNAREKFVLLD 215
                     |.||  .|...:.| |        ::|:   |:...|      .:|:.|.:.:|..
Zfish   181 YPGYDTYVDYIRS--FIDTSYFL-W--------ELQDTLTFDMSAD------GMNDLRARRLLQQ 228

  Fly   216 CPSDILVDVINASIGYNMTGSFNHLFLTNLDTHLSGIDGFYSRDFTVAVAAVRIRTYVPPPVHDE 280
            ..:.:|       :.|.......:||....:..|.| .|:.....::||.    ...:.||....
Zfish   229 IDAQVL-------LVYCSHDEAQYLFSMAREVGLVG-PGYIWFIPSLAVG----NPNIAPPDSFP 281

  Fly   281 IDVFDNSVDTRFSSLGSQLVYDSIVLFYNALLEISQRPGFYIPNFSCGRGFWQPGPRLVEQMKQI 345
            :.:.....|....||.:: |.|.:.:....           :.:|...|||...|     .|..:
Zfish   282 VGLISIITDRWKMSLRNR-VRDGVAIVVKG-----------VESFRKQRGFIPDG-----HMDCL 329

  Fly   346 TPKMVKPPFK--TQRLQINADGQREDFNLE----VYNPIIDRVTHIWNKEFQLVDFEKLRENSTQ 404
            :|  ::|...  ..|..:|...:..||:..    :.||.:..:|....:::..|.      |...
Zfish   330 SP--IRPASNGTLYRHMLNVSWENTDFSFNSDGYLVNPSMIIITLDRGRQWDKVG------NYES 386

  Fly   405 ALKQKRLQNKEDFSQKPI--RY-------------TVATRVGKPYF------------------- 435
            .:.|.|.         |:  ||             ||||...:|:.
Zfish   387 GILQMRY---------PVWPRYGTFLEPVSDNRHLTVATLEERPFVIVEAVDPVTGTCLSNTVPC 442

  Fly   436 ---SWREEPEGVHYEGNERF--EGYAVDLIYMLAQECKFDFNFEPVRDNKYGSYDANTDEWDGII 495
               |.:.|....|.|...:.  :|:.:|::..|::..||.::...|.:.|:|......  |:|:|
Zfish   443 RRQSNKTETIVGHTEPYTKLCCKGFCIDILKKLSRNIKFSYDLYLVTNGKHGKLVRGI--WNGMI 505

  Fly   496 RQLIDNNAQIGICDLTITQARRSVVDFTVPFMQLGISIL---SYKEPPPKADIYAFLNPYNAEVW 557
            .::....|.:.|..|||.:.|..::||:|||::.|||::   |.....|.    |||.||:..||
Zfish   506 GEVFYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPS----AFLEPYSPAVW 566

  Fly   558 LFVMIAMMITAFAL-IFTGRIDQYEWDQPVENVNREMERQN-----IWHLSNALWLVLGSMLNQG 616
            : :|..|.:|..|: :|.     :|:..|| ..||.:....     .:.:..::||:.|.:.|..
Zfish   567 V-MMFVMCLTVVAVTVFV-----FEYCSPV-GYNRSLVSAKDPGGPTFTIGKSVWLLWGIVFNNS 624

  Fly   617 CDL-LPRGLPMRLLTAFWWIFALLISQTYIAKLAAFITSSKIAGDIGSLHDLVDQN------KVQ 674
            ..: .|:|...:::...|..||::...:|.|.||||:...:....:..|.|...|.      ..:
Zfish   625 VPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQDQYPPFR 689

  Fly   675 FGTIRGGATSVYFSESNDTDNRMAWNKMLSFKPDAFTKNNEEGVDRV--KLSKGTY-AFLMETTN 736
            |||:..|:|     |.|...|   :.:|.|.    ..|.|::||:..  .|..|.. ||:.:...
Zfish   690 FGTVPNGST-----ERNIRSN---YPEMHSH----MVKYNQKGVEDALNSLKTGKLDAFIYDAAV 742

  Fly   737 LQYYVQRN--CELTQIGES--FGEKHYGIAVPLNADFRSNLSVGILRLSERGELFKLRNKWFNSN 797
            |.|...::  |:|..||..  |....||||:...:.::..:.:.:|:....|:..||:..|..
Zfish   743 LNYMAGKDEGCKLVTIGSGKVFATTGYGIALQKESRWKRPIDLALLQFLADGDTQKLQTVWLT-- 805

  Fly   798 ESTCDSNVPTIDDGQFDMDSVGGLFVVLIVGVVVGLVIGVAEFL--WHVQRISVK--EKIPPMLA 858
             ..|.:....:...:.|:|::.|:|.:|:|.:.:.|::...|.|  |.: |.||:  |::..:||
Zfish   806 -GICRNEKKEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWKL-RHSVRKSERLDFLLA 868

  Fly   859 LKAEFYFVIRFWLTRKPLHTYRQSRDSTSTGYSSLEQITSASSAKKKKKTRRIE 912
            :....|.... .:.........|:.|.| |.|:....:....:||....:.|:|
Zfish   869 ISRGIYSCFN-GVEDTDRKGNMQNPDVT-TSYTQANMLKMLQTAKDIVSSARVE 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIB	NP_523485.3	PBP1_iGluR_Kainate	26..393	CDD:107377	71/415 (17%)
		ANF_receptor	41..378	CDD:279440	65/381 (17%)
		PBP2_iGluR_Kainate	422..795	CDD:270432	107/434 (25%)
		Lig_chan	555..822	CDD:278489	68/286 (24%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	77/452 (17%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	106/428 (25%)
		NMDAR2_C	847..>938	CDD:313729	18/77 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591063
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830