DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GLR2.1

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_198062.2	Gene:	GLR2.1 / 832768	AraportID:	AT5G27100	Length:	901	Species:	Arabidopsis thaliana

Alignment Length:	1011	Identity:	203/1011 - (20%)
Similarity:	376/1011 - (37%)	Gaps:	258/1011 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VVIYAFIIIIGFLEGIIALGGDDRNEIT---VGAIFYENEKEIELSFDQAFREVNNMKFSEL--- 64
            :|:.....:|.||..:    |:.:|.||   ||.:     .:|..::........||..|:.
plant     7 LVLSLLFFVIVFLMQV----GEAQNRITNVNVGIV-----NDIGTAYSNMTLLCINMSLSDFYSS 62

  Fly    65 ------RFVTIKRYMPTNDSFLLQQITCELISN-GVAAIFGPSSKAASDIVAQIANATGIPHIEY 122
                  |.||.. ....||.........:||:| .|.||.||.:...:..:.::...:.:|.:.|
plant    63 HPETQTRLVTTV-VDSKNDVVTAAAAALDLITNKEVKAILGPWTSMQAQFMIEMGQKSQVPIVTY 126

  Fly   123 DLKLEATRQEQLNHQMSINVAPSLSVLSRAYF---------------EIIKSNYEWRTFTLIYET 172
                .||             :|||:.:...||               ||||. :.||....:|..
plant   127 ----SAT-------------SPSLASIRSQYFFRATYDDSSQVHAIKEIIKL-FGWREVAPVYVD 173

  Fly   173 P---EG-LARLQDLMNIQALNSDYVKLRNLADYADDYR--ILWKETDETFHEQRIILDCEPKT-- 229
            .   || :.||.|:  :|.:|   |::        .||  |....||:....:.:.:...|..
plant   174 DTFGEGIMPRLTDV--LQEIN---VRI--------PYRTVISPNATDDEISVELLRMMTLPTRVF 225

  Fly   230 ---LKELL-------KVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNE---DFKANITSVRLKVV 281
               |.|||       ...|....||..  |.||:..|   .:..|.||   :....:..|:..|.
plant   226 VVHLVELLASRFFAKATEIGLMKQGYV--WILTNTIT---DVLSIMNETEIETMQGVLGVKTYVP 285

  Fly   282 DANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIA-AMQPFHPPNRHCGSSSPWM 345
            .:...|..::|.||         ..||...:...|:|..|...:| |::       ..|:|:
plant   286 RSKELENFRSRWTK---------RFPISDLNVYGLWAYDATTALALAIE-------EAGTSN--- 331

  Fly   346 LGAFIVNEMKTISEDDVEPHFKTENMKLDEYG-------QRIHF----------NLEIYKPTVNE 393
            |....::..:.:||        .:.:.:.:||       .|:.|          |.|: :|:|.|
plant   332 LTFVKMDAKRNVSE--------LQGLGVSQYGPKLLQTLSRVRFQGLAGDFQFINGEL-QPSVFE 387

  Fly   394 PMMV----------WTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVV---------THYEEP- 438
            .:.|          |..:.|:.|   |::.:.|..|...|.|.::..::         ..:|.|
plant   388 IVNVNGQGGRTIGFWMKEYGLFK---NVDQKPASKTTFSSWQDRLRPIIWPGDTTSVPKGWEIPT 449

  Fly   439 ---------------YFMMKEDHENFRGREKYEGYAVDLISKLSELMEFD--YEFMIVNGNGKYN 486
                           ...:|...:.......:.|:::|....:.:.:.:|  |:|:.....|
plant   450 NGKRLQIGVPVNNTFQQFVKATRDPITNSTIFSGFSIDYFEAVIQAIPYDISYDFIPFQDGG--- 511

  Fly   487 PETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLE 551
                 :|.::.::........|.|.||:..|...|||::|:...|:.::........::...||.
plant   512 -----YDALVYQVYLGKYDAVVADTTISSNRSMYVDFSLPYTPSGVGLVVPVKDSVRRSSTIFLM 571

  Fly   552 PFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQ 616
            |..:.:|:..:.:..|:.|. |::  |.:|    .||....|.:.:            :.:|...
plant   572 PLTLALWLISLLSFFIIGLV-VWV--LEHR----VNPDFDGPGQYQ------------LSTIFWF 617

  Fly   617 GCDILPRGPHMRILTG-------MWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKV 674
            ...|:...|..|:|:.       :|:|..|::..:|||:||:.||:.....::.::..|:.:
plant   618 SFSIMVFAPRERVLSFWARVVVIIWYFLVLVLTQSYTASLASLLTTQHLHPTVTNINSLLAK--- 679

  Fly   675 HFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLT 739
              |...|..:|.......|:.:..| :.:...:|....:...:|.|    |.|..|.|||...:.
plant   680 --GESVGYQSSFILGRLRDSGFSEA-SLVSYGSPEHCDALLSKGQA----EGGVSAVLMEVPYVR 737

  Fly   740 YNIERNCD---LTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVT 801
            ..:.:.|:   :.|...::  ...|...|:||....::|.:||::.|..:..:::|.|:|..:.:
plant   738 IFLGQYCNKYKMVQTPFKV--DGLGFVFPIGSPLVADISRAILKVEESNKANQLENAWFKPIDES 800

  Fly   802 C-------DSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLW---NVQNVAVEERVTPW 856
            |       |....|...:|.......:|||.|....:.::..:::||.   |.:|:.|     .|
plant   801 CPDPLTNPDPNPSVSFRQLGFDSFWVLFLVAAIVCTMALLKFVYQFLKENPNQRNLRV-----LW 860

  Fly   857 QAFKAELIFALKFWVRKKPMRISSSSDKSSSRRSSG 892
            :.|             .:|.:.|...|.:..:.|||
plant   861 EKF-------------NEPDQKSYIKDVTKCQCSSG 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	93/447 (21%)
		ANF_receptor	46..386	CDD:279440	83/403 (21%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	74/406 (18%)
		Lig_chan	556..828	CDD:278489	60/288 (21%)
GLR2.1	NP_198062.2	PBP1_GABAb_receptor	49..411	CDD:107361	91/429 (21%)
		ANF_receptor	49..392	CDD:279440	87/407 (21%)
		GluR_Plant	452..794	CDD:270404	71/380 (19%)
		Periplasmic_Binding_Protein_Type_2	478..>685	CDD:304360	46/238 (19%)
		Lig_chan	576..835	CDD:278489	60/289 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920