DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GLR2.6

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001330285.1	Gene:	GLR2.6 / 830988	AraportID:	AT5G11180	Length:	967	Species:	Arabidopsis thaliana

Alignment Length:	954	Identity:	192/954 - (20%)
Similarity:	331/954 - (34%)	Gaps:	260/954 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IIGFLEGIIALGGDDRN--EITVGAIFYENE-------KEIELSFDQAFREVNNMKFSELRFVTI 69
            ::.|:..::.||...:.  ::.||.:...|.       :.|.:|..:.:...|..|   .|.|
plant    16 LLFFINFLVLLGKSQQEVLQVQVGIVLDTNATLAALSLRAINMSLSEFYNTHNGFK---TRIV-- 75

  Fly    70 KRYMPTNDS------------FLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEY 122
               :...||            :|:::       ..|.||.||.:...:..:..:.|.:.:|.|.:
plant    76 ---LNIRDSKRTVVGAAASALYLIKK-------REVVAIIGPGNSMQAPFLINLGNQSQVPIISF 130

  Fly   123 DLKLEATRQEQLNHQMSINVAPSLSVLSRAYF---------------EIIKSNYEWRTFTLIY-- 170
            ...                 :|.|..|...||               .||:| :.||....||
plant   131 SAS-----------------SPVLDSLRSPYFIRATHDDSSQVHAISAIIES-FRWREVVPIYAD 177

  Fly   171 -ETPEG-LARLQDLMNIQALNSDYVKLRNLADYADDYR--ILWKETDE----------TFHEQRI 221
             |..|| |..|.|.  .|.:|   |::|        ||  |....||:          |...:..
plant   178 NEFGEGILPYLVDA--FQEIN---VRIR--------YRSAISVHSTDDLVKKELYKLMTMPTRVF 229

  Fly   222 ILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRD---IYNEDFKANITSVRLKVVDA 283
            |:...|.....|..::.:..:......|.:|      :|:.|   :..|....|:..| |.|  .
plant   230 IVHMLPDLGSRLFSIAKEIGMMTKGYVWIVT------NGIADQMSVMGESSLENMHGV-LGV--K 285

  Fly   284 NPFERKKTRL---TKVDQILGNQTM--LPILIYDAVVLFASSARNVIAAM-QPFHPPNRHCGS-- 340
            ..|.|.|..:   |:..:..|.:.:  .....||.....|.|...:.:.: ..|....|:...
plant   286 TYFSRSKELMYLETRWRKRFGGEELNNFECWGYDTATALAMSIEEISSNVNMSFSQTKRNTSRDD 350

  Fly   341 ------------SSPWMLGAFIVNEMKTISEDDVEPHFKTENMKL----------DEYGQRIHFN 383
                        |.|.:|.|     :.|:|...|...|:.:|.||          :|.|:|
plant   351 TGTDLDDLSFALSGPKLLQA-----LATVSFKGVAGRFQLKNGKLEATTFKIVNIEESGER---- 406

  Fly   384 LEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQR--------------KVYTVVTH 434
                  ||.    .|....|:.|   :|.:...|.....|..|              |.:...|:
plant   407 ------TVG----FWKSKVGLVK---SLRVNQTGIKISHSSHRLRPIIWPGDTIFVPKGWEFPTN 458

  Fly   435 YEEPYFMM--KEDHENF--------RGREKYEGYAVDLISKLSELMEF--DYEFMIVNGNGKYNP 487
            .::....:  |:...||        .......|:.:|:.......|.:  .||::...     .|
plant   459 AKKLRIAVPKKDGFNNFVEVTKDANTNAPTITGFCIDVFDTAMRQMPYAVPYEYIPFE-----TP 518

  Fly   488 ETK---QWDGIIRKLIDHHAQIG-----VCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPK 544
            :.|   .:|.::     :|..:|     |.|.||...|.:.|||.:|:.:.||.::........|
plant   519 DGKPRGSYDEMV-----YHVFLGEFDGAVGDTTILANRSTYVDFALPYSETGIVVVVPVKDEREK 578

  Fly   545 NQFAFLEPFAVEVWIYMIFAQL---IMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNST 606
            .::.||:|...|:|.....:.|   ||...|.:.|...:|:....|       ::.|::..:.||
plant   579 GKWVFLKPLTRELWFLTAASFLYIGIMVWIFEYQASGDFRKQSIIN-------KISNVFYFSFST 636

  Fly   607 WLMVGSIMQQGCDILPRGPHM--------RILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIK 663
            ....               ||        |:|..:|.|..|::..:|||.|.:.||..:.:.:::
plant   637 LFFA---------------HMRPSESIFTRVLVVVWCFVLLILTQSYTATLTSMLTVQELRPTVR 686

  Fly   664 SLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGG 728
            .:.|| ....|:.|...|..|   |.......|:.  :::|.::    |......:...:...||
plant   687 HMDDL-RNSGVNIGYQTGSFT---FERLKQMGYKE--SRLKTYD----TPQEMHELFLKKSSNGG 741

  Fly   729 Y-AFLMETTSLTYNIERNCD-LTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMK 791
            . |...|...:...:.:.|. .|.|........:|.|.||||....:||..||.::|...::.::
plant   742 IDAAFDEVAYVKLFMAKYCSKYTIIEPTFKADGFGFAFPLGSPLVPDLSRQILNITEGETMKAIE 806

  Fly   792 NKW--WKNH---NVTCDSYHEVDGDE----LSIIELGGVFLVLA 826
            |||  .:.|   :.|.||...:|...    .:|:.:..:.|:||
plant   807 NKWLLGEKHCLDSTTSDSPIRLDHHSFEALFTIVFVVSMLLLLA 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	88/453 (19%)
		ANF_receptor	46..386	CDD:279440	81/415 (20%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	87/418 (21%)
		Lig_chan	556..828	CDD:278489	65/293 (22%)
GLR2.6	NP_001330285.1	PBP1_GABAb_receptor_plant	38..421	CDD:380645	90/459 (20%)
		GluR_Plant	460..810	CDD:270404	83/391 (21%)
		Lig_chan	590..842	CDD:365843	62/283 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920