DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GLUR2

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001320141.1	Gene:	GLUR2 / 829682	AraportID:	AT4G35290	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	972	Identity:	209/972 - (21%)
Similarity:	352/972 - (36%)	Gaps:	260/972 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VVIYAFIIIIGFLEGIIALGGDDR-NEITVGAIFYENEKEIE---LSFDQAFREVNN----MKFS 62
            :|:.:||::||  :|:|:.|...| ..:.|||||.....:.|   ::...|..:||:    :..|
plant     5 LVLLSFIVLIG--DGMISEGAGLRPRYVDVGAIFSLGTLQGEVTNIAMKAAEEDVNSDPSFLGGS 67

  Fly    63 ELRFVTIKRYMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEY---DL 124
            :||..|   |....:.||......:.:.....||.||.:...:.:::.:||...:|.:.:   |.
plant    68 KLRITT---YDAKRNGFLTIMGALQFMETDAVAIIGPQTSIMAHVLSHLANELSVPMLSFTALDP 129

  Fly   125 KLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPE----GLARLQDLMNI 185
            .|.|     |.....:..|||...|.||..|:| |.|.|.....:|...:    |:..|.|.:..
plant   130 SLSA-----LQFPFFVQTAPSDLFLMRAIAEMI-SYYGWSEVIALYNDDDNSRNGITALGDELEG 188

  Fly   186 QALNSDYVKLRNLADYADDYRILWKE--TDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRN 248
            :.....|..:..|.......|.:..|  ..:....:.||::..|||.|::.:.:....:......
plant   189 RRCKISYKAVLPLDVVITSPREIINELVKIQGMESRVIIVNTFPKTGKKIFEEAQKLGMMEKGYV 253

  Fly   249 WFLTHLDTHNSGLRDIYN-------EDFKANITSVRLKVVDANPFERKK--TRLTKVDQILGNQT 304
            |..|   |..:.|.|..|       |..:..:|   |::...|..::|.  .|..|:........
plant   254 WIAT---TWLTSLLDSVNPLPAKTAESLRGVLT---LRIHTPNSKKKKDFVARWNKLSNGTVGLN 312

  Fly   305 MLPILIYDAVVLFA-------SSARNVIAAMQPFHPPNRHCGSSSPWMLGA------------FI 350
            :..:..||.|.:.|       .|..|:..:..|.....:..||.:   |||            :|
plant   313 VYGLYAYDTVWIIARAVKRLLDSRANISFSSDPKLTSMKGGGSLN---LGALSIFDQGSQFLDYI 374

  Fly   351 VNEMKT---------ISEDDVEPHFKTENMKLDEYGQ----RIHFNLEIYKPT------------ 390
            ||...|         .....::|.:...|:..|.:.|    ..|..|.|..|.
plant   375 VNTNMTGVTGQIQFLPDRSMIQPSYDIINVVDDGFRQIGYWSNHSGLSIIPPESLYKKLSNRSSS 439

  Fly   391 ------------VNEPMMVWT-PDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMM 442
                        .:|....|. |:||.:.|:      .......|.|               |:.
plant   440 NQHLNNVTWPGGTSETPRGWVFPNNGRRLRI------GVPDRASFKE---------------FVS 483

  Fly   443 KEDHENFRGREKYEGYAVDLISKLSELMEF--DYEFMIVNGNGKYNPETKQW-DGIIRKLIDHHA 504
            :.|     |..|.:|||:|:.....:|:.:  .:||::. |:|..||...:: :.:...:.|  |
plant   484 RLD-----GSNKVQGYAIDVFEAAVKLISYPVPHEFVLF-GDGLKNPNFNEFVNNVTIGVFD--A 540

  Fly   505 QIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQ--FAFLEPFAVEVWIYMIFAQLI 567
            .:|  |:.|...|..:||||.|:::.|:.::   :|....|.  :|||.||...:|        .
plant   541 VVG--DIAIVTKRTRIVDFTQPYIESGLVVV---APVTKLNDTPWAFLRPFTPPMW--------A 592

  Fly   568 MTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRG-PHMRILT 631
            :|.||..|                          |.:..|::...|..:.     || |..:|:|
plant   593 VTAAFFLI--------------------------VGSVIWILEHRINDEF-----RGPPRKQIVT 626

  Fly   632 GMW-------------------------WFFALMML-STYTANLAAFLTSNKWQSSIKSLQDLIE 670
            .:|                         |.|.:::: |:|||:|.:.||..:..|.|:.:..||
plant   627 ILWFSFSTMFFSHRENTVSTLGRAVLLIWLFVVLIITSSYTASLTSILTVQQLNSPIRGVDTLI- 690

  Fly   671 QDKVHFGSMRGGSTSLFFSESNDTDYQ---RAWNQMKD------------FNPSAFTSTNKEGVA 720
                              |.|....:|   .|.|.|.|            .:|..:.:..:.|..
plant   691 ------------------SSSGRVGFQVGSYAENYMIDELNIARSRLVPLGSPKEYAAALQNGTV 737

  Fly   721 RVRKEKGGYA--FLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSE 783
            ....::..|.  ||.|.          |.....|::.....:|.|.|..|....::|.:||.|||
plant   738 AAIVDERPYVDLFLSEF----------CGFAIRGQEFTRSGWGFAFPRDSPLAIDMSTAILGLSE 792

  Fly   784 RGELQKMKNKWWKNHNVTCD----SYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFL 841
            .|:|||:.:||....|  |.    |..:.|.::|.:....|:|||......|.:.:..|:.:
plant   793 TGQLQKIHDKWLSRSN--CSNLNGSVSDEDSEQLKLRSFWGLFLVCGISCFIALFIYFFKIV 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	93/452 (21%)
		ANF_receptor	46..386	CDD:279440	82/396 (21%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	92/418 (22%)
		Lig_chan	556..828	CDD:278489	67/319 (21%)
GLUR2	NP_001320141.1	PBP1_GABAb_receptor_plant	31..422	CDD:380645	86/408 (21%)
		GluR_Plant	466..804	CDD:270404	94/439 (21%)
		Lig_chan	590..840	CDD:395014	67/319 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.770