DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GLR3.6

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001326369.1	Gene:	GLR3.6 / 824311	AraportID:	AT3G51480	Length:	903	Species:	Arabidopsis thaliana

Alignment Length:	1033	Identity:	210/1033 - (20%)
Similarity:	356/1033 - (34%)	Gaps:	310/1033 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LEGIIALGGDDRNEITVGAIFYENE---KEIELSFDQAFREVNNMKFSELRFVTIKRYMPTN--D 77
            |:|:..:.......:.:|::|..|.   |.|:::.|.|..:||... |.|...|::..|...  :
plant    16 LQGLTKIVSARPQVVNIGSVFTFNSLIGKVIKVAMDAAVEDVNASP-SILNTTTLRIIMHDTKYN 79

  Fly    78 SFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINV 142
            .|:......:.:.:...||.||.....:.:||.:|....||.:.:    .||
plant    80 GFMSIMEPLQFMESETVAIIGPQRSTTARVVAHVATELKIPILSF----SAT------------- 127

  Fly   143 APSLSVLSRAYFEIIKSN--------------YEWRTFTLIYETPE----GLARLQDLMNIQALN 189
            .|::|.|...:|.....|              |.||....||...:    |:|.|.|.::.:...
plant   128 DPTMSPLQFPFFIRTSQNDLFQMAAIADIVQFYGWREVVAIYGDDDYGRNGVAALGDRLSEKRCR 192

  Fly   190 SDYVKL-------RNLADYADDYRILWKETDETFHEQRIILDCEPKTL--KELLKVSIDFKLQGP 245
            ..|...       .|:.|      :|.|   ....|.|||: .....:  .||..|:.:..:...
plant   193 ISYKAALPPAPTRENITD------LLIK---VALSESRIIV-VHASFIWGLELFNVARNLGMMST 247

  Fly   246 -----FRNWFLTHLDTHNSGLRDIYNEDFKANITSV---RL----KVVDANPFERKKTRLTKVDQ 298
                 ..||..|.:||.:....|..|     ||..|   ||    .::..| |.::...||.|
plant   248 GYVWIATNWLSTIIDTDSPLPLDTIN-----NIQGVITLRLHTPNSIMKQN-FVQRWHNLTHV-- 304

  Fly   299 ILGNQTMLPILIYDAVVLFASS-------ARNVIAAMQPFHPP----NRHCGSSSPWMLGAF--- 349
              |..| ..:..||.|.|.|.:       ..||..:..|....    |.|..:...:..|..
plant   305 --GLST-YALYAYDTVWLLAQAIDDFFKKGGNVSFSKNPIISELGGGNLHLDALKVFDGGKIFLE 366

  Fly   350 ---------IVNEMKTISEDD-VEPHFKTEN--------------------MKLDEY------GQ 378
                     :...||..|:.: |.|.|...|                    |..||.      ||
plant   367 SILQVDRIGLTGRMKFTSDRNLVNPAFDVLNVIGTGYTTIGYWFNHSGLSVMPADEMENTSFSGQ 431

  Fly   379 RIHFNLEIYKPTVNEPMMVWTPDNGIK----------KRLLNLELESAGTTQDFSEQRKVYTVVT 433
            ::|             .:|| |.:.||          .|.|.:.:
plant   432 KLH-------------SVVW-PGHSIKIPRGWVFSNNGRHLRIGV-------------------- 462

  Fly   434 HYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEF-MIVNGNGKYNPETKQWDGIIR 497
                |.....|:..:.:......|:.||:......|:.:...| ::..|||..||...:   ::|
plant   463 ----PNRYRFEEVVSVKSNGMITGFCVDVFIAAINLLPYAVPFELVAFGNGHDNPSNSE---LVR 520

  Fly   498 KLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPK---NQFAFLEPFAVEVWI 559
            .:.......||.|:||...|..:.|||.|:::.|:.::    .|..|   :..|||.||..::|
plant   521 LITTGVYDAGVGDITIITERTKMADFTQPYVESGLVVV----APVRKLGSSAMAFLRPFTPQMW- 580

  Fly   560 YMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRG 624
                  ||...:|:.:..:.:......|...:.|...:    |..:.|....::...
plant   581 ------LIAAASFLIVGAVIWCLEHKHNDEFRGPPRRQ----VITTFWFSFSTLFFS-------- 627

  Fly   625 PHM--------RILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDL-IEQDKVHF--GS 678
             |.        ||:..:|.|..|::.|:|||:|.:.||.::..|.||.::.| ...|.:.:  ||
plant   628 -HRETTTSNLGRIVLIIWLFVVLIINSSYTASLTSILTVHQLSSPIKGIETLQTNHDPIGYPQGS 691

  Fly   679 MRGGSTSLFFSESNDTDYQRAWNQMKDF----------------NPSAFTSTNKEGVARVRKEKG 727
            .                       ::|:                :|..:....::|..     ||
plant   692 F-----------------------VRDYLIHELNIHVSRLVPLRSPEEYDKALRDGPG-----KG 728

  Fly   728 GYAFLM-ETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMK 791
            |.|.:: |...:...:...|:...:|::..:..:|.|.|..|....::|.:||||||.|::|:::
plant   729 GVAAVVDERAYIELFLSNRCEFGIVGQEFTKNGWGFAFPRNSPLAVDVSAAILQLSENGDMQRIR 793

  Fly   792 NKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPW 856
            :||......:... .|::.|.|.:....|:|:|.  ||...:.|.::..|
plant   794 DKWLLRKACSLQG-AEIEVDRLELKSFWGLFVVC--GVACVLALAVYTVL--------------- 840

  Fly   857 QAFKAELIFALKFWVRKKPMRISSSSDKSSSRRSSGSRR--------SSKE---KSRS 903
                         .:|:...:....::.|..||||.|.|        ..||   |:||
plant   841 -------------MIRQFGQQCPEEAEGSIRRRSSPSARIHSFLSFVKEKEEDAKARS 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	97/464 (21%)
		ANF_receptor	46..386	CDD:279440	89/430 (21%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	84/401 (21%)
		Lig_chan	556..828	CDD:278489	59/299 (20%)
GLR3.6	NP_001326369.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.770