DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GLR1.4

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_187408.2	Gene:	GLR1.4 / 819940	AraportID:	AT3G07520	Length:	861	Species:	Arabidopsis thaliana

Alignment Length:	981	Identity:	185/981 - (18%)
Similarity:	332/981 - (33%)	Gaps:	297/981 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLCPVVIYAFIIIIGFLE----GIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVN---- 57
            |..|.:....:.:.|.||.    .:...|.:.::.:....:.||:.: |.|..|....|..
plant     1 MENCMIRNTGYFLTIFFLAFISFAVTCSGTNQKDNVDRLPVVYEDVR-IGLVVDMGSMEGKLVTT 64

  Fly    58 --NMKFSELRFVTIKRYMPTNDSFL--------LQQITCE---LISNGVAAIFGPSSKAASDIVA 109
              :|..|:  |..:.....|..|.|        ||.:...   |.:..|.|:.|..|...:..:|
plant    65 SISMALSD--FYHVNNGYRTRVSVLSRDSHGDPLQALAAAMDLLQTEQVEALVGGQSLLEAKNLA 127

  Fly   110 QIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSLSVLSRAYF--------------EIIKSN 160
            ::...|.:|.|.                 |..|..|||:....||              ..:.||
plant   128 ELGEKTKVPVIS-----------------SFQVPSSLSLAKYNYFIQATHDTSSEAKGIAALFSN 175

  Fly   161 YEWRTFTLIYETPEGLAR-LQDLMNIQALNSDYVKLRNLADYADDYRILWKETDETFHEQRIILD 224
            ::|||..||||..:.... :|.|:.....|:.::      :|..::.:...|            :
plant   176 FDWRTAVLIYEDDDDWRESIQPLVGHFQQNAIHI------EYKAEFSVSSNE------------E 222

  Fly   225 CEPKTLKELLKVSIDFKLQG-----------------PFRN----------WFLTHLDTHNSGLR 262
            |..|.|::       ||..|                 |...          |.||....:|  .:
plant   223 CIMKQLRK-------FKASGIRIFVAHISERIANRLFPCARRLGMMEEGYAWILTARSMNN--FQ 278

  Fly   263 D---IYNED------FKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFA 318
            |   :..|:      ||:.|....    :.:.|..:..|..::::::...::..|..:|.....|
plant   279 DTNYLAKEEMEGVIGFKSYIPLTE----ELHNFTLRWKRSLRLEEVVTRMSVCSIWAHDIAWSLA 339

  Fly   319 SSAR-------NVIAAMQPFHPPNRHCGSSSP----------------------------WMLGA 348
            .:|.       :|...::......:|.|.|..                            |..|:
plant   340 RAAEVAKLPGLSVYDLLEAIPESAKHKGLSGDIKFIDKKFISDKFEIVNMIGRGERSVGLWNSGS 404

  Fly   349 FIVNEMKTIS-----EDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRL 408
            ||.|..:.:|     |..:.|...|...|:....::.|.                      ||:.
plant   405 FISNRRRRLSSTKALETIIWPGGSTRIPKIRSLKEKRHG----------------------KKKK 447

  Fly   409 LNLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFD 473
            |.:.:.:...|....|                 :|.|.:.  |.....||.:|:..  :.::.|:
plant   448 LRVLVPAGNITPQILE-----------------VKTDFKT--GVTAATGYCIDVFE--TSILPFN 491

  Fly   474 YEFMIVNGNGKYNPETKQWDGIIRKLID----HHAQIGVCDLTITQMRRSVVDFTVPFMQLGISI 534
            ||...:...|..|  .|.::.::..|..    :.|.:|  |:|||..|...||||:||..:|:::
plant   492 YEVEYIPWPGAIN--YKNYNDLVYTLYSQKDKYDAAVG--DITITDNRSLYVDFTLPFTDMGLAV 552

  Fly   535 LHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENI 599
            :..|.    |:.:...:|..:.:|: .|.:..|:|.|.|         ||     |:..|..:
plant   553 VTAKD----KSMWIIFKPLTLSLWL-TIASFFILTGAIV---------WL-----IERHDNAD-- 596

  Fly   600 WNVNNSTWLMVGSIMQQGCDIL-----PRGPH--MRILTGMWWFFALMMLSTYTANLAAFLTSNK 657
              ...|.:..:|:::..|...|     .|..|  .|.:..:|.|..|::.|.|||.|.:.:|
plant   597 --FQGSCFQQIGTLLCFGFSTLVFAHRERLQHNMSRFVVIVWIFAVLILTSNYTATLTSVMT--- 656

  Fly   658 WQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARV 722
                ::.::.|...:.:.|.|   .|.:......|.|.....:..:|  ....||:..:.|....
plant   657 ----VQQIRGLKSNENIGFFS---ASIAANVVNDNPTFQGPRYKGLK--TADDFTNALRNGTISF 712

  Fly   723 RKEKGGYA-----------FLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSV 776
            ..::..|.           .::||.|:|                  ..:|.|...||.....:|.
plant   713 IVDEVPYVKLFVAKHPSEFVIVETESVT------------------NGFGFAFQKGSPLVQKVSR 759

  Fly   777 SILQLSERGELQKMKNKWWKNHNVTC----DSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGI 837
            .|.:|....:|:.::| ||.....|.    |::|     .|::....|:|::.  ||.....|.:
plant   760 EIEKLRRTEKLKAIEN-WWFQRQTTSATSEDTFH-----PLTVYTFRGLFMIT--GVSFAFALIV 816

  Fly   838 FEFLWN 843
            :...||
plant   817 YLIPWN 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	81/478 (17%)
		ANF_receptor	46..386	CDD:279440	78/447 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	81/391 (21%)
		Lig_chan	556..828	CDD:278489	58/293 (20%)
GLR1.4	NP_187408.2	PBP1_GABAb_receptor	47..410	CDD:107361	73/413 (18%)
		ANF_receptor	64..390	CDD:279440	64/375 (17%)
		GluR_Plant	448..778	CDD:270404	84/408 (21%)
		Periplasmic_Binding_Protein_Type_2	476..>657	CDD:304360	53/216 (25%)
		Lig_chan	570..810	CDD:278489	60/296 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920