DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GLR5

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_565744.1	Gene:	GLR5 / 817801	AraportID:	AT2G32400	Length:	921	Species:	Arabidopsis thaliana

Alignment Length:	1048	Identity:	217/1048 - (20%)
Similarity:	370/1048 - (35%)	Gaps:	308/1048 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VVIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENE---KEIELSFDQAFREVNN----MKFSE 63
            |.|.|.|::|    .::.:.......:.:||:|..:.   :..:::.:.|..:|||    :|.:|
plant     9 VAITALIVVI----LVVPMDCQRPQLVNIGAVFAFDSVIGRAAKVALEAAVSDVNNDKSFLKETE 69

  Fly    64 LRFVTIKRYMPTNDSFLLQQITC----------ELISNGVAAIFGPSSKAASDIVAQIANATGIP 118
            ||             .|::...|          ||:...|.|:.||.|.:.:..::.||.....|
plant    70 LR-------------LLMEDSACNVFRGSFGAFELLEKEVVAMIGPISSSVAHTISDIAKGLHFP 121

  Fly   119 HIEY---DLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPE----GL 176
            .:.:   |..|.|     |.....:...|:.:....|..::| :.|.|:....:|...|    |:
plant   122 LVSFAATDPTLSA-----LQFPFFLRTTPNDAHQMSALVDLI-NFYGWKEVISVYSDDELGRNGV 180

  Fly   177 ARLQD-----------------------LMNIQALNSD-------YV------KLRNLADYADDY 205
            :.|.|                       |.|  |||..       |:      .|..:.|.|...
plant   181 SALDDELYKKRSRISYKVPLSVHSDEKFLTN--ALNKSKSIGPRVYILHFGPDPLLRIFDIAQKL 243

  Fly   206 RIL-----WKETDETFHEQRIILD--CEPKTLKELLKV--------------SIDFKLQGPFRN- 248
            :::     |..||..    .:.||  .:..|||.|..|              ....|||.. |:
plant   244 QMMTHEYVWLATDWL----SVTLDSLSDKGTLKRLEGVVGLRQHIPESVKMEHFTHKLQSN-RSM 303

  Fly   249 -----------WFLTHLDTHNSGLRDIYNEDFKANIT-SVRLKVVDANPFERKKTRLTKVDQILG 301
                       |.:.|      |:.::.||..  ||| |...|::.|   ...|..|.|:.....
plant   304 NAYALHAYDTVWMIAH------GIEELLNEGI--NITFSYSEKLLHA---RGTKLHLEKIKFFNS 357

  Fly   302 NQTMLPILI---YDAV---VLFASSARNVIAAMQPFHPPNR---HCGSSSPWML-GAFIVNEMKT 356
            .:.:|..|:   :..:   |.| .|.||||.........|:   |  :...|.. |.|.|...||
plant   358 GELLLEKLLKVNFTGIAGQVQF-GSGRNVIGCDYEIINVNKTDVH--TVGFWSKNGGFSVVAPKT 419

  Fly   357 ISEDDVEPHFKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQD 421
            .....     ||..:..::.|.                 :.| |..|.:|....:..:||...:.
plant   420 RHSQK-----KTSFVSDEKLGD-----------------ITW-PGGGREKPRGWVIADSADPLKI 461

  Fly   422 FSEQRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVN-GNGKY 485
            ...:|     |:..|   |:.:|.:.:.|    .:|:.:|:..:..:.:.:...::... |||..
plant   462 VVPRR-----VSFVE---FVTEEKNSSHR----IQGFCIDVFIEALKFVPYSVPYIFEPFGNGHS 514

  Fly   486 NPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKN-QFAF 549
            :|   .::.:|:.:.|......|.|:.|...|..:|||:.|:...|:.::   .|....| .:.|
plant   515 SP---NYNHLIQMVTDGVYDAAVGDIAIVPSRSKLVDFSQPYASTGLVVV---IPANDDNATWIF 573

  Fly   550 LEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIM 614
            |.||...:|..::.:.|::.:..                                  |::...|.
plant   574 LRPFTSRLWCVVLVSFLVIAVVI----------------------------------WILEHRIN 604

  Fly   615 QQGCDILPRGPHMRILTGMW--------------------------WFFALMML-STYTANLAAF 652
            :..     |||..|.|:.|.                          |.|.||:| ::|||||.:.
plant   605 EDF-----RGPPRRQLSTMLLFSFSTLFKRNQEDTISNLARLVMIVWLFLLMVLTASYTANLTSI 664

  Fly   653 LTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSES------------NDTDYQRAWNQMKD 705
            ||..:..|:|..: |.:...:|..|...|..|..:.:.|            :..:|::|..
plant   665 LTVQQLPSAITGI-DSLRASEVPIGYQAGTFTLEYLTYSLGMARSRLVPLDSTEEYEKALK---- 724

  Fly   706 FNPSAFTSTNKEGVARVRKEKGGY--AFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGS 768
            ..|     ||..|||.:..|. .|  .||.|.|....          :||....:.:|.|....|
plant   725 LGP-----TNWGGVAAIVDEL-PYIELFLAERTGFKI----------VGEPFMHRGWGFAFKRDS 773

  Fly   769 DYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLV----LAGGV 829
            ....::|.:||:|||..:||:::.||....|....|....:.::|.:....|::||    .....
plant   774 PLAIDMSTAILKLSETRKLQEIRKKWLCKTNCAGKSNWNPEPNQLHLKSFKGLYLVCIAITVSAF 838

  Fly   830 LIGVILGIFEFL--WNVQNVAVEERVTPWQAFKA----ELIFALKFWVRKKPMRISSSSDKSSSR 888
            |:.|:..|.:|:  ..::..:...|.: |.|...    ||:|....:|.:|...|     |...|
plant   839 LVFVLRMIRQFVRYRRMERTSSMPRAS-WSASPTLRLRELVFDFVEFVDEKEEAI-----KRMFR 897

  Fly   889 RSSGSRRS 896
            ||..|..:
plant   898 RSDDSNNN 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	96/474 (20%)
		ANF_receptor	46..386	CDD:279440	91/440 (21%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	88/412 (21%)
		Lig_chan	556..828	CDD:278489	65/316 (21%)
GLR5	NP_565744.1	PBP1_GABAb_receptor	32..416	CDD:107361	89/423 (21%)
		ANF_receptor	46..396	CDD:279440	80/387 (21%)
		GluR_Plant	458..800	CDD:270404	87/419 (21%)
		Lig_chan	581..832	CDD:278489	65/310 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.770