DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GLR2.2

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_180048.1	Gene:	GLR2.2 / 817008	AraportID:	AT2G24720	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	991	Identity:	204/991 - (20%)
Similarity:	368/991 - (37%)	Gaps:	268/991 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VIYAFIIIIGF--LEGIIALGGDD-RNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVT 68
            :.:.|:.:..|  ||.  :.|.|: :.::.:|.:     .::..|:........||..::  |.:
plant     6 LFFRFLFLFFFFCLES--SRGQDNGKTQVNIGVV-----SDVGTSYPDVAMLCINMSLAD--FYS 61

  Fly    69 IKRYMPT----------NDSFLLQQITCELISN-GVAAIFGPSSKAASDIVAQIANATGIPHIEY 122
            .:....|          ||.........:||.| .|.||.||.:...:..:.:|...:.:|.:.|
plant    62 SRPQFQTRLVVNVGDSKNDVVGAATAAIDLIKNKQVKAILGPWTSMQAHFLIEIGQKSRVPVVSY 126

  Fly   123 DLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYE----------------WRTFTLIY- 170
                .||             :|||:.|...||  .::.||                ||....:|
plant   127 ----SAT-------------SPSLTSLRSPYF--FRATYEDSSQVHAIKAIIKLFGWREVVPVYI 172

  Fly   171 --ETPEG-LARLQDLMNIQALNSDYVKLRNLADYADDYR--ILWKETDETFHEQ---------RI 221
              ...|| :.||.|  ::|.:|   |::        .||  |....||:....:         |:
plant   173 DNTFGEGIMPRLTD--SLQDIN---VRI--------PYRSVIPLNATDQDISVELLKMMNMPTRV 224

  Fly   222 ILDCEPKTLKELLKVSI-DFKLQGPFRNWFLTH--LDTHNSGLRDIYNEDFKA--NITSVRLKVV 281
            .:.....:|...:.:.. :..|..|...|.||:  :|    |||.|.....:|  .:..::..:.
plant   225 FIVHMSSSLASTVFIKAKELGLMKPGYVWILTNGVMD----GLRSINETGIEAMEGVLGIKTYIP 285

  Fly   282 DANPFE----RKKTRLTKVD-QILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSS 341
            .:...|    |.|.|..::: .:.|      :..|||....|.:..:.......|..
plant   286 KSKDLETFRSRWKRRFPQMELNVYG------LWAYDATTALAMAIEDAGINNMTFSN-------- 336

  Fly   342 SPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRI----------------HFNLEIYKPT 390
                     |:..|.:||.|        .:.|.::|.::                ||.....:|:
plant   337 ---------VDTGKNVSELD--------GLGLSQFGPKLLQTVSTVQFKGLAGDFHFVSGQLQPS 384

  Fly   391 VNEPMMV----------WTPDNGIKKRLLNLELESAGTTQDFSEQRK-------VYTVVTHYEEP 438
            |.|.:.:          ||..||:.|: |:.|..|.||...:.:..|       ..:|...:|.|
plant   385 VFEIVNMIGTGERSIGFWTEGNGLVKK-LDQEPRSIGTLSTWPDHLKHIIWPGEAVSVPKGWEIP 448

  Fly   439 ----------------YFMMKEDHENFRGREKYEGYAVDLISKLSELMEFD--YEFMIV---NGN 482
                            ..::|...:........:|:.:|....:.:.|.:|  |||...   ||.
plant   449 TNGKKLRIGVPKRIGFTDLVKVTRDPITNSTVVKGFCIDFFEAVIQAMPYDVSYEFFPFEKPNGE 513

  Fly   483 --GKYNPETKQWDGIIRKLIDHHAQIG-----VCDLTITQMRRSVVDFTVPFMQLGISILHYKSP 540
              |.:|.            :.|...:|     |.|.||...|.|.||||:|||:.|:.::.....
plant   514 PAGNHND------------LVHQVYLGQFDAVVGDTTILANRSSFVDFTLPFMKSGVGLIVPLKD 566

  Fly   541 PEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNS 605
            ...:::|:||:|.::|:|        :.||.|.|:..:|.  |...:....|   .....|...|
plant   567 EVKRDKFSFLKPLSIELW--------LTTLVFFFLVGISV--WTLEHRVNSD---FRGPANYQAS 618

  Fly   606 T--WLMVGSIMQQGCDILPR------GPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSI 662
            |  |....:::     ..||      |....::|  |:|..|::..:|||:||:.|||.:...:|
plant   619 TIFWFAFSTMV-----FAPRERVLSFGARSLVVT--WYFVLLVLTQSYTASLASLLTSQQLNPTI 676

  Fly   663 KSLQDLIEQDKVHFGSMRG-GSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEK 726
            .|:..|:     |.|...| ..||....:.|:|.:.:  :.:..|:    |:...:.:.:...:.
plant   677 TSMSSLL-----HRGETVGYQRTSFILGKLNETGFPQ--SSLVPFD----TAEECDELLKKGPKN 730

  Fly   727 GGY-AFLMETTSLTYNIERNCD-LTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQK 789
            ||. |..:.|..:...:.:.|: ...:.|......:|...|:||....::|.:||:::|..:..:
plant   731 GGVAAAFLGTPYVRLFLGQYCNTYKMVEEPFNVDGFGFVFPIGSPLVADVSRAILKVAESPKAVE 795

  Fly   790 MKNKWWKNHNVTC-------DSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGI----FEFLWN 843
            :::.|:|....:|       ||...|...:|.:.....:|||    |.:..:|.:    |.|||.
plant   796 LEHAWFKKKEQSCPDPVTNPDSNPTVTAIQLGVGSFWFLFLV----VFVVCVLALGKFTFCFLWK 856

  Fly   844 VQNVAVEERVTPWQAF 859
            .:...:      |:.|
plant   857 TKGKDL------WKEF 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	83/448 (19%)
		ANF_receptor	46..386	CDD:279440	76/407 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	91/415 (22%)
		Lig_chan	556..828	CDD:278489	64/289 (22%)
GLR2.2	NP_180048.1	PBP1_GABAb_receptor	33..412	CDD:107361	85/453 (19%)
		ANF_receptor	47..392	CDD:279440	78/413 (19%)
		HisJ	438..>587	CDD:223904	37/168 (22%)
		GluR_Plant	452..801	CDD:270404	86/391 (22%)
		Lig_chan	582..819	CDD:278489	59/267 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920