DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and GLR2.3

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001325281.1	Gene:	GLR2.3 / 817007	AraportID:	AT2G24710	Length:	919	Species:	Arabidopsis thaliana

Alignment Length:	977	Identity:	187/977 - (19%)
Similarity:	355/977 - (36%)	Gaps:	276/977 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKR 71
            ::..|...:.|..|    ..:.:..:.||.:     .:::.|..:......||..|:
plant    34 ILLVFFFCLEFNRG----QNNGKTLVDVGVV-----TDVDTSHSKVVMLCINMSISD-------- 81

  Fly    72 YMPTNDSFLLQQI----------------TCELISN-GVAAIFGPSSKAASDIVAQIANATGIPH 119
            :..:|..|..:.:                ..:||.| .|.||.||.:...:..:.:|...:.:|.
plant    82 FYSSNPQFETRLVVNVGDSKSDVVGAAIAALDLIKNKQVKAILGPWTSMQAHFLIEIGQKSRVPI 146

  Fly   120 IEYDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYE----------------WRTFTL 168
            :.|    .||             :|.|:.|...||  :::.||                ||....
plant   147 VSY----SAT-------------SPILTSLRSPYF--LRATYEDSFQVQPIKAIIKLFGWREVVP 192

  Fly   169 IY---ETPEG-LARLQDLMNIQALNSDYVKLRNLADYADDYR--ILWKETDETFHEQRIILDCEP 227
            :|   ...|| :.||.|     ||....|::        .||  |....||   ||..:
plant   193 VYIDNTFGEGIMPRLTD-----ALQDINVRI--------PYRSVIAINATD---HEISV------ 235

  Fly   228 KTLKELLKV-----------------------SIDFKLQGPFRNWFLTHLDTHNSGLRD---IYN 266
                ||||:                       :.:..|..|...|.||      :|:.|   :.|
plant   236 ----ELLKMMNMPTRVFLVHMYYDLASRFFIKAKELGLMEPGYVWILT------NGVIDDLSLIN 290

  Fly   267 E---DFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIA-A 327
            |   :....:..::..:..:...|:.::|.         :::.|.:......|:|..|...:| |
plant   291 ETAVEAMEGVLGIKTYIPKSPDLEKFRSRW---------RSLFPRVELSVYGLWAYDATTALAVA 346

  Fly   328 MQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRI------------ 380
            ::       ..|:::  |..:.:|:..:.:||        .|.:.|.::|.::
plant   347 IE-------EAGTNN--MTFSKVVDTGRNVSE--------LEALGLSQFGPKLLQTLLTVQFRGL 394

  Fly   381 ----HFNLEIYKPTVNEPMMV----------WTPDNGIKKRL--LNLELESAGTTQDF------- 422
                .|.....:|:|.|.:.:          |...||:.|:|  ....:.:..|.:|.
plant   395 AGEFRFFRGQLQPSVFEIVNIINTGEKSIGFWKEGNGLVKKLDQQASSISALSTWKDHLKHIVWP 459

  Fly   423 -------------SEQRKVYTVV---THYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELME 471
                         ::.:|:...|   |.|.:   ::|...:.........|:.:|....:...:.
plant   460 GEADSVPKGWQIPTKGKKLRIGVPKRTGYTD---LVKVTRDPITNSTVVTGFCIDFFEAVIRELP 521

  Fly   472 FD--YEFMIV---NGN--GKYNPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQ 529
            :|  |||:..   :|.  |.||      |.:.:..:..:..: |.|.||...|.|.||||.||::
plant   522 YDVSYEFIPFEKPDGKTAGNYN------DLVYQVYLGRYDAV-VGDTTILVNRSSYVDFTFPFIK 579

  Fly   530 LGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPD 594
            .|:.::...:.|..::...|::|.:.::|: ..|....:....|::  |.|:.    ||....|.
plant   580 SGVGLIVEMTDPVKRDYILFMKPLSWKLWL-TSFISFFLVGCTVWV--LEYKR----NPDFSGPP 637

  Fly   595 ELENIWNVNNSTWLMVGSIMQQGCDILPR----GPHMRILTGMWWFFALMMLSTYTANLAAFLTS 655
            ..:    .:...|....:::     ..||    ....|.|...|:|..|::..:|||:||:.|||
plant   638 RFQ----ASTICWFAFSTMV-----FAPRERVFSFWARALVIAWYFLVLVLTQSYTASLASLLTS 693

  Fly   656 NKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVA 720
            .|...:|.|:..|:|:.:. .|..|   ||....:..:..:.:  :.:..|:    |:...:.:.
plant   694 QKLNPTITSMSSLLEKGET-VGYQR---TSFILGKLKERGFPQ--SSLVPFD----TAEECDELL 748

  Fly   721 RVRKEKGGY--AFLMETTSLTYNIERNCD-LTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLS 782
            ....:|||.  ||| |...|...:.:.|: ...:.|......:|...|:||....::|.:||:::
plant   749 SKGPKKGGVSGAFL-EIPYLRLFLGQFCNTYKMVEEPFNVDGFGFVFPIGSPLVADVSRAILKVA 812

  Fly   783 ERGELQKMKNKWWKNHNVTC-------DSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEF 840
            |..:..:::..|:|....:|       |........:|.|    ..||.|..|||:..::.:..|
plant   813 ESPKAMELERAWFKKKEQSCPDPITNPDPNPSFTSRQLDI----DSFLFLFVGVLLVCVMALGNF 873

  Fly   841 LW 842
            .:
plant   874 TY 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	81/465 (17%)
		ANF_receptor	46..386	CDD:279440	74/424 (17%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	86/386 (22%)
		Lig_chan	556..828	CDD:278489	62/285 (22%)
GLR2.3	NP_001325281.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1813
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.920