Protein Alignment GluRIIA and GLR2

DIOPT Version :9

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_001318239.1
• Gene: GLR2 / 816231
• AraportID: AT2G17260
• Length: 925
• Species: Arabidopsis thaliana
• Alignment Length: 1048
• Identity: 221/1048 - (21%)
• Similarity: 396/1048 - (37%)
• Gaps: 289/1048 - (27%)

  Fly     7 VIYAFIIIIGFLEGIIALGGDDRNE---ITVGAIFYENE---KEIELSFDQAFREVNN----MKF 61
            |:.:|||::|  .|::...|...:.   |.|||||..|.   :...::|..|..:||:    :..
plant     8 VLLSFIIVLG--GGLLLSEGASSSRPPVIKVGAIFGLNTMYGETANIAFKAAEEDVNSDPSFLGG 70

  Fly    62 SELRFVTIKRYMPTNDS----FLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEY 122
            |:||.:       .||:    ||......:.:...|.||.||.:...:.:::.:||...:|.:.:
plant    71 SKLRIL-------MNDAKRSGFLSIMGALQFMETDVVAIIGPQTSIMAHVLSHLANELTVPMLSF 128

  Fly   123 DLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPE----GLARLQDLM 183
             ..|:.| ...|.....:..|||...|.||..|:| :.|.|.....:|...:    |:..|.|.:
plant   129 -TALDPT-LSPLQFPFFVQTAPSDLFLMRAIAEMI-TYYGWSDVVALYNDDDNSRNGVTALGDEL 190

  Fly   184 NIQALNSDY--------------------VKLRNLADYADDYRILWKETDETFHEQR-IILDCEP 227
            ..:.....|                    :|:|.:                   |.| |:::..|
plant   191 EERRCKISYKAVLPLDVVITSPVEIIEELIKIRGM-------------------ESRVIVVNTFP 236

  Fly   228 KTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKAN------ITSVRLKVVDANPF 286
            .|.|.:.|.:....:......|..|      :.|..:.:.:...:      :.::||...|:
plant   237 NTGKMIFKEAERLGMMEKGYVWIAT------TWLSSVLDSNLPLDTKLVNGVLTLRLHTPDS--- 292

  Fly   287 ERKKTRLTK--VDQILGNQT----MLPILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPWM 345
             |||.....  .:::..|:|    :..:..||.|.:.|.:.:.::.|       ..:...|:...
plant   293 -RKKRDFAARWKNKLSNNKTIGLNVYGLYAYDTVWIIARAVKTLLEA-------GGNLSFSNDAK 349

  Fly   346 LGAFIVNEMKTISEDDVEPHFKTENMKL------DEYGQRIHFNLEIYKPTVNEPMMVWTPDNGI 404
            ||:                 .|.|.:.|      |:..|.:.:.:......:..|:. :.||..:
plant   350 LGS-----------------LKGEALNLSALSRFDQGSQLLDYIVHTKMSGLTGPVQ-FHPDRSM 396

  Fly   405 KK---RLLNL---ELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKEDHEN--------------- 448
            .:   .::||   .:...|...::|....|.....:.:.|.......|.|
plant   397 LQPSYDIINLVDDRVHQIGYWSNYSGLSIVPPESFYSKPPNRSSSNQHLNSVTWPGGTSVTPRGW 461

  Fly   449 -FR--GR-----------------------EKYEGYAVDLISKLSELMEF--DYEFMIVNGNGKY 485
             ||  ||                       .|.:||.:|:.....:|:.:  .:|| |..|:|..
plant   462 IFRNNGRRLRIGVPDRASFKDFVSRVNGSSNKVQGYCIDVFEAAVKLLSYPVPHEF-IFFGDGLT 525

  Fly   486 NPETKQWDGIIRKL---IDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPE--PKN 545
            ||   .::.::.|:   :|..|.:|  |:.|...|..:||||.|:::.|:.::   :|..  .:|
plant   526 NP---NYNELVNKVTTGVDFDAVVG--DIAIVTKRTRIVDFTQPYIESGLVVV---APVTRLNEN 582

  Fly   546 QFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMV 610
            .:|||.||.:.:|        .:|.:|..|                          |..:.|::.
plant   583 PWAFLRPFTLPMW--------AVTASFFVI--------------------------VGAAIWILE 613

  Fly   611 GSIMQQGCDILPRGPHMR-ILTGMW-------------------------WFFALMML-STYTAN 648
            ..|..:.     |||..| |:|.:|                         |.|.:::: |:|||:
plant   614 HRINDEF-----RGPPRRQIITILWFTFSTMFFSHRETTVSTLGRMVLLIWLFVVLIITSSYTAS 673

  Fly   649 LAAFLTSNKWQSSIKSLQDLIEQ-DKVHFGSMRGGSTSLFFSESNDTD-YQRAWNQMKDF-NPSA 710
            |.:.||..:..|.||.:..||.. .::.|   :.||    |:|:..|| ...|.:::... :|..
plant   674 LTSILTVQQLNSPIKGVDTLISSTGRIGF---QVGS----FAENYMTDELNIASSRLVPLASPEE 731

  Fly   711 FTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLS 775
            :.:..:.|......::..|..|..:....:.| |..:.|:.|       :|.|.|..|....::|
plant   732 YANALQNGTVAAIVDERPYIDLFLSDYCKFAI-RGQEFTRCG-------WGFAFPRDSPLAVDMS 788

  Fly   776 VSILQLSERGELQKMKNKWWKNHNVTCDSYH---EVDGDELSIIELGGVFLVLAGGVLIGVILGI 837
            .:||.|||.|||||:.::|....|  |.|.|   ..|.::|::....|:|||:....|:.:.:..
plant   789 TAILGLSETGELQKIHDRWLSKSN--CSSPHGSQSGDSEQLNVHSFWGMFLVVGIACLVALFIHF 851

  Fly   838 F----EFLWNVQNVAVEE--------RVTPWQAFKAELIFALKFWVRKKPMRISSSSDKSSSRRS 890
            |    :|..:...|.|||        |:|..|.|.|  ....|....|:.::...::|.|.:..|
plant   852 FKIIRDFCKDTPEVVVEEAIPSPKSSRLTKLQTFLA--FVDEKEEETKRRLKRKRNNDHSMNANS 914

  Fly   891 SGSRRSSK 898
            ..||.:|:
plant   915 IISRTASR 922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	79/424 (19%)
		ANF_receptor	46..386	CDD:279440	70/390 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	100/447 (22%)
		Lig_chan	556..828	CDD:278489	70/304 (23%)
GLR2	NP_001318239.1	PBP1_GABAb_receptor	35..424	CDD:107361	83/452 (18%)
		GluR_Plant	468..808	CDD:270404	92/402 (23%)
		Lig_chan	594..843	CDD:306551	70/304 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	82	0.746	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.770