DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and grik5

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001315085.1	Gene:	grik5 / 798791	ZFINID:	ZDB-GENE-070821-6	Length:	1067	Species:	Danio rerio

Alignment Length:	813	Identity:	255/813 - (31%)
Similarity:	417/813 - (51%)	Gaps:	71/813 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 DSFLLQQ--------ITCELISNGVAAIFGP-SSKAASDIVAQIANATGIPHIEYDLKLEATRQE 132
            |.|.||:        ..|:::..||.::.|| ||.|:..||:.|.....|||::...: |..|..
Zfish    79 DIFELQKDSQYETTDTMCQILPKGVVSVIGPASSPASGSIVSHICGEKEIPHVKIGPE-ETPRLP 142

  Fly   133 QLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRN 197
            .|.. .|:.:.||...||.|...|::| :.:.:.:|:....|.|.||::|:....::.:.:.:|.
Zfish   143 YLRF-ASVTLYPSNEDLSLAIGSILRS-FSYPSASLVCAKAECLLRLEELIRRFLISRETLSIRM 205

  Fly   198 LADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLR 262
            |.|..|...:|.:..|:..  ..||:|........:||.:.:..:...|..:.||.:|.....|.
Zfish   206 LDDNLDPTPLLKEIRDDKI--ATIIIDANASISYLILKKASELGMTSAFYKYILTTMDFPLLWLD 268

  Fly   263 DIYNEDFKANITSVRL--------------------KVVDANPFERKKTRLTKVDQILGNQTMLP 307
            ||.:|  ::||....:                    :..|.||:.              ...:..
Zfish   269 DIVDE--QSNIVGFSMFNTTHPFYLEFIRSLNLSWREGCDINPYP--------------GPALSS 317

  Fly   308 ILIYDAVVLFASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMK 372
            .|::|||.:..|:.:.:..:.:....| ..|.|...|..|..::|.::.:..|.:     |..::
Zfish   318 ALLFDAVHVVVSAVQELNRSQEIGVKP-LSCTSPQIWQHGTSLMNYLRMVEYDGL-----TGRVE 376

  Fly   373 LDEYGQRIHFNLEIYKP--TVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHY 435
            .:..|||.::.|.|.:.  ..::.:.:|..:|.:.....:|::..:.|..:     |...:.|..
Zfish   377 FNSKGQRTNYTLHILEKHRGGHKEIGIWYSNNTLLMNSTSLDINVSETLAN-----KSLIITTIL 436

  Fly   436 EEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYN-PETK-QWDGIIRK 498
            |.||.|.|.:::.|.|.|:|||:.||::.:||::::|.|...:|: :|.|. ||.. .|.|::.:
Zfish   437 ENPYVMRKINYQEFEGNEQYEGFCVDMLRELSDILKFTYRIKLVD-DGLYGAPEPNGSWTGMVGE 500

  Fly   499 LIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIF 563
            ||:..|.:.|...|||..|..|:||:.|||.||||||:..........|:||:||:..||::|:.
Zfish   501 LINRKADLAVAAFTITSEREKVIDFSKPFMTLGISILYRVHIGRKPGYFSFLDPFSPAVWLFMLL 565

  Fly   564 AQLIMTLAFVFIARLSYREWLPPNPAIQD-PDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHM 627
            |.|.::......||||..||..|:|.::: .|.|||.:.:.||.|..||..||||.:|:||....
Zfish   566 AYLAVSCVLFLSARLSPYEWYNPHPCLRERRDLLENQYTLGNSLWFPVGGFMQQGSEIMPRALST 630

  Fly   628 RILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESN 692
            |.::|:||.|.|:::|:||||||||||..:.:..|:|..||.:|..:.:|::.||||..||..|.
Zfish   631 RCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESPDDLADQTNIQYGTIHGGSTMTFFMNSR 695

  Fly   693 DTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGE 757
            ...|||.||.|....||.|..:.:||:|||...|  ||||:|:|...|:...||:|||||..:..
Zfish   696 YQTYQRMWNYMYSKQPSVFVKSTEEGIARVVNSK--YAFLLESTMNEYHRSLNCNLTQIGGLLDT 758

  Fly   758 KHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVF 822
            |.||:.:||||.:|..||:::|||.|...|:.:|.:||:......:..|...|  |.:..:||:|
Zfish   759 KGYGIGMPLGSPFRDELSLAVLQLQENNRLEILKRRWWEGGKCPKEEDHRAKG--LGMENIGGIF 821

  Fly   823 LVLAGGVLIGVILGIFEFLWNVQNVAVEERVTP 855
            :||..|::|.|.:.:.||:|:.:..|..:.|.|
Zfish   822 VVLICGLIIAVFVAVMEFVWSTRRSAETDEVRP 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	79/357 (22%)
		ANF_receptor	46..386	CDD:279440	76/337 (23%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	156/372 (42%)
		Lig_chan	556..828	CDD:278489	114/272 (42%)
grik5	NP_001315085.1	PBP1_iGluR_Kainate_KA1_2	38..412	CDD:107389	79/359 (22%)
		ANF_receptor	55..392	CDD:279440	77/339 (23%)
		Periplasmic_Binding_Protein_Type_1	<313..383	CDD:299141	14/75 (19%)
		Periplasmic_Binding_Protein_Type_2	427..797	CDD:304360	156/377 (41%)
		Lig_chan	558..828	CDD:278489	114/273 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591086
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750