DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and gria1a

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_991161.1	Gene:	gria1a / 798689	ZFINID:	ZDB-GENE-020125-1	Length:	914	Species:	Danio rerio

Alignment Length:	893	Identity:	259/893 - (29%)
Similarity:	434/893 - (48%)	Gaps:	130/893 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELRFVTIKRYMPTND------SFL 80
            :..|....:.|.:|.:|.....|.|:           .:|:......|.:.:|..|      ||.
Zfish    15 LCFGSSFPSNINIGGLFPTESHEYEV-----------FRFALSHHQDIPKLVPQVDMVKLGNSFS 68

  Fly    81 LQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPS 145
            :....|...|.||.||.|...:...:::.....|..:..:.....:|.      ::|..|.:.|.
Zfish    69 MTYAFCSQFSKGVYAIIGVYDRKTVNMLMSFCGALHVCFVTPSFPMEN------SNQFVIQLRPE 127

  Fly   146 LSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYAD-DYRILW 209
               |..|...:|: :|.|..|..:|.:..||:.||.:::..|.::..|...|:....: .:..::
Zfish   128 ---LQDALVGVIE-HYRWSKFVYMYSSDSGLSVLQKVLDTAAEHNWLVTSVNVETMTEASFLKVF 188

  Fly   210 KETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFK---A 271
            ::.|:. .|.:||:|||.:.|..:||..|:..     :|....|....|.|..||...:||   |
Zfish   189 QDLDKK-KEGQIIIDCELERLTSILKKIIELG-----KNVKSYHYILANLGFLDIDLTEFKKGEA 247

  Fly   272 NITSVRL-KVVDAN---------PFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNV-- 324
            |:|..:| ...|.|         .|:.|..::.|     ........|.||.|.:.:::.:|:
Zfish   248 NVTGFQLVNYADPNVSRTVQQWMEFDNKDAKVPK-----RRLKYTGALTYDGVKVMSTAFQNLRR 307

  Fly   325 --------------IAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDE 375
                          :|     :||       :||..|..|...::.:..:.:..|     ::.:|
Zfish   308 QRIDISRRGNAGECLA-----NPP-------APWGQGIDIQRALQQVRIEGLTGH-----IQFNE 355

  Fly   376 YGQRIHFNLEI--YKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEP 438
            .|:|.::::.:  .:||..:.:..|..|    ::.::......|:.:.:..|.:.|.|.|..|.|
Zfish   356 KGRRTNYSISVMELRPTGPKKVGYWNED----EKFVSTAAYMPGSNETYGLQNRTYIVTTILESP 416

  Fly   439 YFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQWDGIIRKLI 500
            |.|:|::||:|.|.:|||||.|:|.:::::.:.:.|...|| .:|||   :.||..|:|::.:|:
Zfish   417 YVMLKKNHEHFTGNDKYEGYCVELAAEIAKHVGYHYILKIV-ADGKYGARDAETMMWNGMVGELV 480

  Fly   501 DHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQ 565
            ...|.:.|..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.|:|:.::||.
Zfish   481 YGKADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPTKSKPGVFSFLDPLAYEIWMCIVFAY 545

  Fly   566 LIMTLAFVFIARLSYREW-----------LPPNPAI-------------QDPDELENIWNVNNST 606
            :.:::....::|.|..||           .|..|:.             |...|..|.:.:.||.
Zfish   546 IGVSVVLFLVSRFSPYEWHADDCEDGAEENPNQPSSSSAQPGQNQQNQNQQSQEQTNEFGIFNSL 610

  Fly   607 WLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQ 671
            |..:|:.|||||||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|
Zfish   611 WFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 675

  Fly   672 DKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETT 736
            .::.:|::..|||..||..|....:::.|:.||..:||.|..|..|||.||||.||.||:|:|:|
Zfish   676 TEIAYGTLDAGSTKEFFRRSKIAVFEKMWSYMKSADPSVFVKTTDEGVMRVRKSKGKYAYLLEST 740

  Fly   737 SLTYNIERN-CDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNV 800
            ...|..:|. ||..::|..:..|.||:|.|.||..|..:::::|:|:|:|.|.|:|||||.:..
Zfish   741 MNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSPLRNPVNLAVLKLNEQGLLDKLKNKWWYDKG- 804

  Fly   801 TCDSYHEVDGDE------LSIIELGGVFLVLAGGVLIGVILGIFEFLW 842
            .|.|   ..||.      ||:..:.|||.:|.||:.:.:::.:.||.:
Zfish   805 ECGS---GGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALVEFCY 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	84/408 (21%)
		ANF_receptor	46..386	CDD:279440	77/375 (21%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	156/397 (39%)
		Lig_chan	556..828	CDD:278489	113/302 (37%)
gria1a	NP_991161.1	Periplasmic_Binding_Protein_Type_1	26..387	CDD:299141	84/413 (20%)
		ANF_receptor	36..369	CDD:279440	78/381 (20%)
		PBP2_iGluR_AMPA_GluR1	404..806	CDD:270447	157/403 (39%)
		Lig_chan	536..836	CDD:278489	114/303 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591012
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740