DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and grik1a

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_009303592.1	Gene:	grik1a / 798001	ZFINID:	ZDB-GENE-030131-6502	Length:	919	Species:	Danio rerio

Alignment Length:	895	Identity:	280/895 - (31%)
Similarity:	451/895 - (50%)	Gaps:	98/895 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DRNEITVGAIFYENEKE----IELSFDQAFREVNNMKFSELRFVTIKRYMPTN------------ 76
            ::..|.:|.||...|.|    .||:|..|...:|..          :..||..
Zfish    35 EQQVIRIGGIFETRENEPVSMDELAFKFAVTSINRN----------RTLMPNTTLTYDIQRVNLF 89

  Fly    77 DSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSIN 141
            |||...:..|:.::.||||:||||..::...|..|.||..:|||:...|..:...:.   ...||
Zfish    90 DSFEASRRVCDQLALGVAAVFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKD---NFYIN 151

  Fly   142 VAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYR 206
            :.|..:.:|||..:|: ..|:|:..|::||...||.|:|:|:...:.|:..:::|.|.....|.|
Zfish   152 LYPEYTSISRAILDIV-IFYKWKCVTVVYEDSTGLMRMQELIKAPSKNNLKIRIRQLPSGGGDSR 215

  Fly   207 ILWKE--TDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDF 269
            .|.||  .::.|:   :|.||..:...||||..:...:...:.::|.|.||.....|     |.:
Zfish   216 PLLKEMKKEKEFY---VIFDCSYQVAAELLKQLMSMGMMTEYYHFFFTTLDLFALDL-----EPY 272

  Fly   270 K---ANITSVRL---------KVVDANPFERKKTRLTKVDQIL-GNQTMLPILIYDAVVLFASSA 321
            :   .|:|:.||         .|:.....||:.........:: |..|....|:||||.:.|.::
Zfish   273 RYSGVNMTAFRLLNLDDSYVASVIQKWSMERQLAPPKPESGLMSGIMTTAAALMYDAVFMVAVAS 337

  Fly   322 RN----VIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHF---KTENMKLDEYGQR 379
            :.    .::::|        |....||..|...:|..|....|.:....   ||:       |.|
Zfish   338 QRATQMTVSSLQ--------CHRHKPWRYGPRFMNLFKEAQWDGLTGRIVLNKTD-------GLR 387

  Fly   380 IHFNLEIYK-----------PTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSEQ--RKVYTV 431
            ..|||::..           ...:.|..:|| ..|:......|.|......::.::.  .:...|
Zfish   388 KEFNLDLISLKEDGTAKRVADGASRPNKLWT-KIGVWNSYTGLNLTEIKDNKNITDSLANRTLIV 451

  Fly   432 VTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNPETK--QWDG 494
            .|..|.||.|.|:..:...|.:::|||.:||:.:||.::.|.||..:|. :|||..:..  :|:|
Zfish   452 TTILENPYVMYKKSDKVLYGNDRFEGYCLDLLKELSNILGFTYEVKLVT-DGKYGAQNDKGEWNG 515

  Fly   495 IIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWI 559
            ::|:||||.|.:.|..||||.:|..|:||:.|||.||||||:.|........|:||.|...::|:
Zfish   516 MVRELIDHIADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLTPDIWM 580

  Fly   560 YMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRG 624
            |::.|.|.::.....|||.:..||..|:|.....:.:||.:.:.||.|..|.::|:||.:::|:.
Zfish   581 YVLLACLGVSCVLFVIARFTPYEWYNPHPCNPSSEVVENNFTLLNSLWFGVAALMRQGSELMPKA 645

  Fly   625 PHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFS 689
            ...|||.|:||||.|:::|:||||||||||..:..|.|.|..||.:|.::.:|::|.|||..||.
Zfish   646 LSTRILGGIWWFFTLIIISSYTANLAAFLTVERMDSPIDSADDLAKQTRIEYGAVRDGSTMTFFK 710

  Fly   690 ESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQ 754
            :|..:.|::.|..|.....:|....:|:|:.||...  .||.|||:||:.|..:|||:|||:|..
Zfish   711 KSKISTYEKMWAFMSSRKNTALVKNSKDGITRVLTT--DYALLMESTSIEYITQRNCNLTQVGGL 773

  Fly   755 IGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELG 819
            |..|.||:..|:||.||..::::||||.|.|:|..||.|||:.:.  |......:...|.:..:|
Zfish   774 IDSKGYGVGTPIGSPYRDKVTIAILQLQEEGKLHMMKEKWWRGNG--CPEEDSKEASALGVENIG 836

  Fly   820 GVFLVLAGGVLIGVILGIFEFLW-NVQNVAVEERVTPWQAFKAELIFALK 868
            |:|:|||.|:::.|.:.|.||:: :.:|..:||.|: :.|...:|..:|:
Zfish   837 GIFIVLAAGLVLSVFVAIGEFIYKSHKNSDIEECVS-FSAVMEDLGISLR 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	104/419 (25%)
		ANF_receptor	46..386	CDD:279440	96/373 (26%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	151/371 (41%)
		Lig_chan	556..828	CDD:278489	107/271 (39%)
grik1a	XP_009303592.1	Periplasmic_Binding_Protein_Type_1	37..432	CDD:299141	107/432 (25%)
		ANF_receptor	57..398	CDD:279440	96/377 (25%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:304360	151/371 (41%)
		Lig_chan	577..846	CDD:278489	107/272 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591025
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650