Protein Alignment GluRIIA and Grid2

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: NP_077355.2
• Gene: Grid2 / 79220
• RGDID: 68368
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 919
• Identity: 232/919 - (25%)
• Similarity: 404/919 - (43%)
• Gaps: 144/919 - (15%)

  Fly    32 ITVGAIFYENEKEIELSFDQAFREVN-NMKFSELRFVTIK-RYMPTNDSFLLQQITCELISNGVA 94
            |.:||||.|:.|:.:..|..|..::| |.:..:...:|.. .::..|:.|...|..|||::.|:.
  Rat    27 IHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGIL 91

  Fly    95 AIFGPSSKAASDIVAQIANATGIPHIEYDLKLEAT-------RQEQLNHQMSINVAPSLSVLSRA 152
            |:.......::..:..:|:|..|||:........|       .:...|...:::|.|.: .|:..
  Rat    92 ALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPV-YLNEV 155

  Fly   153 YFEIIKSNYEWRTFTLIYETPEGLARLQDLM-----------------NIQALNS---DYVKLRN 197
            ...:: :.|.|:.|.:.|::...:..:|:.:                 ||..:.:   |.:::..
  Rat   156 ILRVV-TEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEE 219

  Fly   198 LADYADDYRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLR 262
            |..|.|..|             |.||...|.|.|..:...::..|.....:|.:.:.:.::..::
  Rat   220 LNRYRDTLR-------------RAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQ 271

  Fly   263 DIYNEDFKANITSVRLKV-VDANPFER--------KKTRLTKVDQILGNQTMLPILIYDAVVLFA 318
            ::..... ..:|.:|... |..|..:|        ..|.....|....|..:..:.|||.|:|.|
  Rat   272 ELVRRSI-GRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLA 335

  Fly   319 SSARNVIAAMQPFHPPNRHC--GSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIH 381
            ::....:...:.....:..|  .:|.||..|.   :.::||.:..|  :..|.:::..|.|...:
  Rat   336 NAFHKKLEDRKWHSMASLSCIRKNSKPWQGGR---SMLETIKKGGV--NGLTGDLEFGENGGNPN 395

  Fly   382 FNLEIYKPTVNE-------PMMVWTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPY 439
            .:.||......|       .:..|.|..|:...|.:.:||:       :.:..|..|||..|||:
  Rat   396 VHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLEN-------NMRGVVLRVVTVLEEPF 453

  Fly   440 FMMKEDHENFRGR-EKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYNP-ETKQWDGIIRKLIDH 502
            .|:.   ||..|: :||:|:::|::..||..:.|:||..:...:...:| |...|:|::.:|:..
  Rat   454 VMVS---ENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFK 515

  Fly   503 HAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLI 567
            .|.||:..||||..|.:|||||..:|...:.:| .:...:..:.||.|.||.:.:|..:....|:
  Rat   516 RADIGISALTITPDRENVVDFTTRYMDYSVGVL-LRRAEKTVDMFACLAPFDLSLWACIAGTVLL 579

  Fly   568 MTLAFVFIARLSYREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTG 632
            :.|....:      .||.| |.:|.......  .:.||.|.:.||.:|||.::.......|::.|
  Rat   580 VGLLVYLL------NWLNP-PRLQMGSMTST--TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMG 635

  Fly   633 MWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGS-----------MRGGSTSL 686
            .||.|||:::|:||||||||||..:.:|||:|||||.:|..:.:|:           |:|.:..
  Rat   636 AWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDSAVYQHVRMKGLNPF- 699

  Fly   687 FFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEK-GGYAFLMETTSLTYNI--ERNCDL 748
                ..|:.|.:.|..:...|.|  .:...|..|.::|.| |.|||:.:...|.|..  :.:|..
  Rat   700 ----ERDSMYSQMWRMINRSNGS--ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSF 758

  Fly   749 TQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVD---- 809
            ..:|..:.::.||:|:..||.||...|..||:|.:.|::..:|:|||.. |..||.|..||
  Rat   759 YTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPK-NGQCDLYSSVDAKQK 822

  Fly   810 GDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAELIFALKFWVRKK 874
            |..|.|..|.|||.:||.|:::..::.:.|               .|             |.|:|
  Rat   823 GGALDIKSLAGVFCILAAGIVLSCLIAVLE---------------TW-------------WSRRK 859

  Fly   875 PMRISSSSD 883
            ..|:.|..|
  Rat   860 GSRVPSKED 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	80/418 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	123/385 (32%)
		Lig_chan	555..828	CDD:459656	94/290 (32%)
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		64/333 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	80/421 (19%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	123/385 (32%)
		Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007