Protein Alignment GluRIIA and grin1

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_012825220.1
• Gene: grin1 / 780048
• XenbaseID: XB-GENE-494200
• Length: 941
• Species: Xenopus tropicalis
• Alignment Length: 1025
• Identity: 223/1025 - (21%)
• Similarity: 388/1025 - (37%)
• Gaps: 236/1025 - (23%)

  Fly     1 MRLCPVVIYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNNMKFSELR 65
            |||       |::.:.||.. .|..|.|...:.:||:....:.|      |.|||..|.  :..|
 Frog     4 MRL-------FLLAVLFLFS-FARAGCDPKIVNIGAVLSTKKHE------QIFREAVNQ--ANKR 52

  Fly    66 FVTIK--------RYMPTNDSFLLQQITCE-LISNGVAAIF-----GPSSKAASDIVAQIANATG 116
            ..|.|        .:.|......|.  .|| |||:.|.||.     .|:.......::..|....
 Frog    53 HGTWKIQLNATSVTHRPNAIQMALS--VCEDLISSQVYAILVSHPPAPTDHLTPTPISYTAGFYR 115

  Fly   117 IPHIEYDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIY-ETPEGLARLQ 180
            ||.|....::.....:.: |...:...|..|..:..:||:::. :.|....||. :..||.|..:
 Frog   116 IPVIGLTTRMSIYSDKSI-HLSFLRTVPPYSHQALVWFEMMRL-FNWNHVILIVSDDHEGRAAQK 178

  Fly   181 DLMNIQALNSDYVKLRNLADYADDYRILWKETDETFHEQR------IILDCEPKT---------L 230
            .|..:........|.||           ::..|:..::.:      .:|..||.|         .
 Frog   179 KLETLLEEKESKSKKRN-----------YENLDQLSYDNKRGPKADKVLQFEPGTKNLTALLLEA 232

  Fly   231 KEL------LKVSID-----------FKLQGPFRNWFLTHLDTHNSGLRDIYNEDFKANITSVRL 278
            |||      |..|.|           ..:.|....|.:...:...|.||  |..|....:..:..
 Frog   233 KELEARVIILSASEDDATAVYKSAAMLDMTGAGYVWLVGEREISGSALR--YAPDGIIGLQLING 295

  Fly   279 KVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSARNVIAAMQPFHPPNRHC-GSSS 342
            |...|:                         |.|||.: |:.|.:.:..|:....|.|.| |:::
 Frog   296 KNESAH-------------------------ISDAVAV-AAQAIHELFEMENITDPPRGCVGNTN 334

  Fly   343 PWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYK----------------PTV 391
            .|..|..    .|.:......|...|..::.:|.|.|...|..|..                ...
 Frog   335 IWKTGPL----FKRVLMSSKYPDGVTGRIEFNEDGDRKFANYSIMNLQNRKLVQVGIFNGSHVIQ 395

  Fly   392 NEPMMVWTPDNGIKKRLLNLELESAGTTQ-----DFSEQRKVYTVVTHYEEPYFMMKEDHENFRG 451
            |:..::|                ..|.|:     ..|.:.|:.|:   ::||:..:|....:...
 Frog   396 NDRKIIW----------------PGGETERPQGYQMSTRLKIVTI---HQEPFVYVKPTMTDGTC 441

  Fly   452 REKYE-----------------------------GYAVDLISKLSELMEFDYEFMIVNGNGKY-- 485
            ||:|.                             |:.:||:.||:..|.|.||..:| .:||:
 Frog   442 REEYTINGDPIKKVICNGPNETIPGRPTVPQCCYGFCIDLLIKLAREMNFTYEVHLV-ADGKFGT 505

  Fly   486 -----NPETKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKN 545
                 |...|:|:|::.:|:...|.:.|..|||...|...::|:.||...|::||..|..|. ..
 Frog   506 QERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPR-ST 569

  Fly   546 QFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNP----AIQDPDELENIWNVNNST 606
            ..:|::||...:|:.:..:..::.:....:.|.|        |    .:...:|.|:...::::.
 Frog   570 LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFS--------PFGRFKVNSEEEEEDALTLSSAM 626

  Fly   607 WLMVGSIMQQGC-DILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQD--- 667
            |...|.::..|. :..||....|||..:|..||::::::|||||||||..::.:..|..:.|
 Frog   627 WFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRL 691

  Fly   668 LIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFL 732
            ....||..:.:::..|..::|  ....:....:..|:..|    ..:..|.:..||..| .:||:
 Frog   692 RNPSDKFIYATVKQSSVDIYF--RRQVELSTMYRHMEKHN----YESAAEAIQAVRDNK-LHAFI 749

  Fly   733 METTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKN 797
            .::..|.:...:.|||...||......:|:.:...|.::.|:|::||:..|.|.::::...|.:.
 Frog   750 WDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLNILKSHENGFMEELDKTWVRY 814

  Fly   798 HNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKAE 862
            ..  |||...... .|:...:.|||:::|||::.|:.|...|..:.....|..:::        :
 Frog   815 QE--CDSRSNAPA-TLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQM--------Q 868

  Fly   863 LIF-ALKFWVR----KKPMRISSSSDKSSSRRSSGS--------RRSSKE 899
            |.| |:..|.:    :|..|......|.:|.||..|        |||||:
 Frog   869 LAFAAVNVWRKNLQDRKSGRAEPDPKKKASFRSITSTLASSFKRRRSSKD 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	84/435 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	97/413 (23%)
		Lig_chan	555..828	CDD:459656	63/280 (23%)
grin1	XP_012825220.1	PBP1_iGluR_NMDA_NR1	25..404	CDD:380602	84/449 (19%)
		PBP2_iGluR_NMDA_Nr1	416..818	CDD:270437	98/423 (23%)
		CaM_bdg_C0	854..882	CDD:402271	5/35 (14%)