DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRIIA and grik5-like.1

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001072565.1	Gene:	grik5-like.1 / 780020	XenbaseID:	XB-GENE-5860197	Length:	479	Species:	Xenopus tropicalis

Alignment Length:	462	Identity:	146/462 - (31%)
Similarity:	237/462 - (51%)	Gaps:	36/462 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   414 ESAGTTQDFSEQR-----KVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFD 473
            ||.|:.....|:.     |..||.|..|:|:.|..|        ...||:.:||:|:|::.:.|:
Frog    23 ESKGSIHKEKERSKRQALKHLTVTTIMEQPFSMKTE--------SGMEGFCIDLLSELAQSLGFN 79

  Fly   474 YEFMIVNGNGKYNPETK--QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILH 536
            |....|. :|:|..:.:  .|:|::.:::...|.:.|..||||..|...:.||.||||.|||||.
Frog    80 YTIKEVK-DGRYGAKDQDGNWNGMVGEVLRKEADLAVAPLTITGARERELAFTKPFMQTGISILL 143

  Fly   537 YKSP-PEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDEL---E 597
            .|.. .|....|.||.||:.|.||.::.|.::.:|....:.|||..||          .||   :
Frog   144 RKDDVSENSYLFGFLTPFSKETWIGILVAYVVTSLCLFLVGRLSPCEW----------TELSTEQ 198

  Fly   598 NIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQ-SS 661
            |.:|..||.|..||:...||.:..|:....||:..:||.|::::::.|.|:.||||.|:..| ::
Frog   199 NNFNFLNSLWFGVGAFTLQGAEPHPKSVSARIIAVIWWIFSIVLVAAYIASFAAFLNSDSMQTTN 263

  Fly   662 IKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEK 726
            |::.:||:.|..:.||::...||..||..|.:..|:..:..|..........:..|||.||:  :
Frog   264 IQTFEDLVNQRTLEFGTINSSSTFQFFKNSKNPTYRMIYEYMDKRKDELLVKSFAEGVRRVK--E 326

  Fly   727 GGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMK 791
            ..||||.|:......:.::|||.:..:.|..:.||:|..|.|.....|||:||:.:|.|.::.::
Frog   327 SNYAFLGESVMQDIMVAKHCDLVRAPQIIAGRGYGIAASLDSPLIKPLSVAILEQTESGNIEYLR 391

  Fly   792 NKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPW 856
            .|||.|   ||:.......:.:....|||:||:|..|:.:|||..:.|.:...:|.|.:::.:..
Frog   392 KKWWDN---TCNMKRSAGWNPVQPHTLGGIFLILGIGLALGVIAALVELVLKARNNADQQKKSCC 453

  Fly   857 QAFKAEL 863
            .||..|:
Frog   454 SAFSEEM 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377
		ANF_receptor	46..386	CDD:279440
		PBP2_iGluR_Kainate	426..796	CDD:270432	122/381 (32%)
		Lig_chan	556..828	CDD:278489	86/275 (31%)
grik5-like.1	NP_001072565.1	PBP2_iGluR_non_NMDA_like	41..396	CDD:270403	122/375 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910