DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and grin2ab

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_009304490.1	Gene:	grin2ab / 570493	ZFINID:	ZDB-GENE-070424-223	Length:	1445	Species:	Danio rerio

Alignment Length:	864	Identity:	195/864 - (22%)
Similarity:	347/864 - (40%)	Gaps:	209/864 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 CELIS----NGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSL 146
            |||:|    :|:....|...:|.:.::..:::.|.:|.:........|..|:.:.........||
Zfish    76 CELMSRQRLHGLVYGDGTDQEAVAQMLDFVSSQTSMPILGIHGGSAMTMAEKDSSSSFFQFGASL 140

  Fly   147 ---SVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDYRIL 208
               ::|..|..|    .|:|..|:::.....|   .|:.:....:..|:..:|
Zfish   141 QQEALLMLAIME----EYDWHVFSVVTTKFPG---FQEFIATVRVTVDHSFVR------------ 186

  Fly   209 WK-----------ETDETFHEQR-------IILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLD 255
            |.           |.::..|.|.       |:|.|.......:::.:....|.|....|.:..|.
Zfish   187 WDLQSVVTLDGVGEPEDRAHVQLKRIQSPVILLYCSKDEAALVMEEARSLGLTGAGFVWIVPSLT 251

  Fly   256 THNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASS 320
            |.|  |..| .|.|.|.:.||.....| .|.|   |||                 .|||.:.:|:
Zfish   252 TGN--LEHI-PEAFPAGMISVTYDEWD-YPLE---TRL-----------------QDAVGIISSA 292

  Fly   321 ARNVIAAM-------------------QPFHPPNRHCGSSSPWMLGAFIVNEMKTISED--DVEP 364
            |    |||                   :|..||:    :...:|:|..:..:..:..:|  .|.|
Zfish   293 A----AAMFREEGRIPDGTASCYGQSEKPEVPPS----ALRRYMMGVNLGGKDHSFMDDGYQVNP 349

  Fly   365 H-----FKTENMKLDEYGQRIHFNLEIYKPTVNEPMMVWTPDNGIKKRLLNLELESAGTTQDFSE 424
            .     ..||. :.::.|:..:.:|.:..|       ||...|            |.|   |...
Zfish   350 KLVVIVLNTER-EWEKMGRWENHSLRLKFP-------VWPRYN------------SFG---DMDA 391

  Fly   425 QRKVYTVVTHYEEPYFMMKEDHENFRG-----------------------REKYEGYAVDLISKL 466
            .....::||..|.| |::.:|.:...|                       ::..:|:.:|::.|:
Zfish   392 DENHLSIVTLEERP-FVIVDDVDILTGTCMRNSVPCRKHIKDNTTEGSYVKKCCKGFCIDILKKI 455

  Fly   467 SELMEFDYEFMIVNGNGKYNPETKQ-WDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQL 530
            :..::|.|:..:|. |||:..:... |:|::.:::...|.:.|..|||.:.|...:||:|||::.
Zfish   456 ARNVKFTYDLYLVT-NGKHGKKINNVWNGMVGEVVYKKAVMAVGSLTINEERSEAIDFSVPFVET 519

  Fly   531 GISILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMT----LAFVFIARLSYREWL----- 584
            |||::..:|  ...|.   ||||||:..||:.|....||:|    ..|.||:.|.:...|
Zfish   520 GISVMVSRSNGTVSPS---AFLEPFSASVWVMMFVMLLIVTAIAVFLFEFISPLGFNRNLAQGKD 581

  Fly   585 PPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDIL-PRGPHMRILTGMWWFFALMMLSTYTAN 648
            |..|:          :.:..:.||:.|.:......:. |||...:.:..:|.|||::.|::||||
Zfish   582 PHGPS----------FTIGKAVWLLWGLVFNNSVPVQNPRGTTSKFIVSVWAFFAVIFLASYTAN 636

  Fly   649 LAAFLTSNKWQSSIKSLQDLIEQD------KVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFN 707
            ||||:...::...:..|.|...|.      ...||::..|||        :.:.::.:..|..:
Zfish   637 LAAFMIQEEFVDQVTGLSDRKFQSPYSYSPPFRFGTVPNGST--------ERNIRKNYPAMHQY- 692

  Fly   708 PSAFTSTNKEGV--ARVRKEKGGY-AFLMETTSLTYNIERN--CDLTQIGEQ--IGEKHYGLAVP 765
               ....::.||  |.|..:.|.. ||:.:...|.|...|:  |.|..||..  .....||:|:.
Zfish   693 ---MVKYHQTGVVDALVSLKTGKLDAFIYDAAVLNYMAGRDDGCKLVTIGSGYIFATTGYGIAMQ 754

  Fly   766 LGSDYRTNLSVSILQLSERGELQKMKNKWWKN--HNVTCDSYHEVDGDELSIIELGGVFLVLAGG 828
            .||.::..:.::||.:...||:::::.:|...  ||    ..:||...:|.:..:.|||.:||..
Zfish   755 KGSYWKRLVDLAILGIIGDGEMEELEAQWLTGICHN----EKNEVMSSQLDVDNMAGVFYMLAAA 815

  Fly   829 VLIGVILGIFE--FLWNVQ 845
            :.:.:|..::|  |.|.::
Zfish   816 MALSLITFVWEHLFYWRLR 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	73/368 (20%)
		ANF_receptor	46..386	CDD:279440	69/350 (20%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	105/418 (25%)
		Lig_chan	556..828	CDD:278489	75/296 (25%)
grin2ab	XP_009304490.1	PBP1_iGluR_NMDA_NR2	25..382	CDD:107373	72/364 (20%)
		ANF_receptor	48..358	CDD:279440	65/332 (20%)
		PBP2_iGluR_NMDA_Nr2	393..790	CDD:270436	105/423 (25%)
		Lig_chan	544..816	CDD:278489	75/297 (25%)
		NMDAR2_C	827..1445	CDD:287527	2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930