DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and grin2bb

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_001121809.1	Gene:	grin2bb / 559976	ZFINID:	ZDB-GENE-061207-27	Length:	1770	Species:	Danio rerio

Alignment Length:	911	Identity:	205/911 - (22%)
Similarity:	374/911 - (41%)	Gaps:	190/911 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ITVGAIFYENEKEIELSFDQAFREVNNMKF-SELRFVTIKRYMPTNDSFLLQQITCELIS----N 91
            :::..|...|..|:.||......:..::.. .::..||:..   |:...::.:| |.|:|    .
Zfish   109 LSIAVILVGNSSEVSLSEGLEKEDFLHVPLPPKVELVTMNE---TDPKSIINRI-CALMSRNWLQ 169

  Fly    92 GVAAIFGPSS--KAASDIVAQIANATGIPHIEYDLKLEATRQEQLNHQMSINVAPSLSVLSRAYF 154
            ||  :||..:  :|.:.|:..|:..|.||.:............:.:|.|.....||:...:....
Zfish   170 GV--VFGDDTDQEAIAQILDFISAQTHIPILGIRGGSSMIMAAKDDHSMFFQFGPSIEQQASVML 232

  Fly   155 EIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYA------DDYRILWKETD 213
            .|:: .|:|..|:::.....|   .||.:|         ::|:..|.:      ::..:|....|
Zfish   233 NIME-EYDWYIFSIVTTYYPG---HQDFVN---------RIRSTVDNSFVGWELEEVLLLDMSVD 284

  Fly   214 E----------TFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHL---DTHN------S 259
            :          ......|:|.|..:....:.:|:....|.|....|.:..|   ||.|      :
Zfish   285 DGDSKIQNQMKKLQSPVILLYCTKEEATTIFEVAHSVGLTGYGYTWIVPSLVAGDTDNVPNVFPT 349

  Fly   260 GLRDI-YNE-DFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFASSAR 322
            ||..: |:| |:     .:..:|.||.......|....:|:  |..|:|....:.|
Zfish   350 GLISVSYDEWDY-----GLEARVRDAVAIIAMATSTMMLDR--GPHTLLKSGCHGA--------- 398

  Fly   323 NVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIY 387
                      |..:...|.:|..:..:::|..           |:..|:...|.|.::|..|.|.
Zfish   399 ----------PDKKGSKSGNPNEVLRYLMNVT-----------FEGRNLSFSEDGFQMHPKLVII 442

  Fly   388 ---KPTVNEPMMVWTPDNG---IKKRLL-NLELESAGTTQDFSEQRKVYTVVTHYEEPYFMMKED 445
               |....|.:..|  :||   :|..:. ..||.|     |..|:...:..:...||..|::.||
Zfish   443 LLNKERQYERVGKW--ENGSLAMKYHVWPRFELYS-----DAEEREDDHLSIVTLEEAPFVIVED 500

  Fly   446 HENFRG--------------------------REKYEGYAVDLISKLSELMEFDYEFMIVNGNGK 484
            .:...|                          :...:|:.:|::.|:::.::|.|:..:|. |||
Zfish   501 VDPLSGTCMRNTVPCRKQLKLQNLTGDSGIYIKRCCKGFCIDILKKIAKSVKFTYDLYLVT-NGK 564

  Fly   485 YNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKS--PPEPKNQ 546
            :..:.. .|:|::.:::..:|.:.|..|||.:.|..|:||:|||::.|||::..:|  ...|.
Zfish   565 HGKKINGTWNGMVGEVVLKNAHMAVGSLTINEERSEVIDFSVPFIETGISVMVSRSNGTVSPS-- 627

  Fly   547 FAFLEPFAVEVWIYMIFAQLIMTLAFVFI----ARLSYREWL-----PPNPAIQDPDELENIWNV 602
             ||||||:.:||:.|....||::...||:    :.:.|...|     |..|:          :.:
Zfish   628 -AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPS----------FTI 681

  Fly   603 NNSTWLMVGSIMQQGCDIL-PRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQ 666
            ..:.||:.|.:......:. |:|...:|:..:|.|||::.|::||||||||:...::...:..|.
Zfish   682 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVTGLS 746

  Fly   667 DLIEQ------DKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGV-ARVRK 724
            |...|      ....||::..|||.           :...|..|:.: |..||.:::.| ..:..
Zfish   747 DKKFQHPNDFSPPFRFGTVPNGSTE-----------RNIRNNYKEMH-SYMTSFHQKNVNEALHS 799

  Fly   725 EKGGY--AFLMETTSLTYNIERN--CDLTQIGEQ--IGEKHYGLAVPLGSDYRTNLSVSILQLSE 783
            .|.|.  ||:.:...|.|...|:  |.|..||..  .....||:|:...|.::..:.::||||..
Zfish   800 LKSGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGYIFATTGYGIAIQKDSGWKRAVDLAILQLFG 864

  Fly   784 RGELQKMKNKWWKN--HNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFE--FLWNV 844
            .||:::::..|...  ||    ..:||...:|.:..:.|||.:|...:.:.:|..|.|  |.|.:
Zfish   865 DGEMEELEALWLTGICHN----EKNEVMSSQLDVDNMAGVFYMLGAAMALSLITFIAEHLFYWQL 925

  Fly   845 Q 845
            :
Zfish   926 R 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	79/410 (19%)
		ANF_receptor	46..386	CDD:279440	70/373 (19%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	106/421 (25%)
		Lig_chan	556..828	CDD:278489	75/296 (25%)
grin2bb	NP_001121809.1	PBP1_iGluR_NMDA_NR2	107..470	CDD:107373	80/418 (19%)
		ANF_receptor	138..442	CDD:279440	68/359 (19%)
		PBP2_iGluR_NMDA_Nr2	482..882	CDD:270436	106/425 (25%)
		Lig_chan	636..908	CDD:278489	75/297 (25%)
		NMDAR2_C	919..1770	CDD:287527	2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740