DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and grik4

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_021322087.1	Gene:	grik4 / 556582	ZFINID:	ZDB-GENE-070821-5	Length:	965	Species:	Danio rerio

Alignment Length:	800	Identity:	243/800 - (30%)
Similarity:	402/800 - (50%)	Gaps:	89/800 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 CELISNGVAAIFGPS-SKAASDIVAQIANATGIPHI----EYDLKLEATRQEQL-----NHQMSI 140
            |:::|.||.|:.||| |.|::.|::.|.....:|::    |..||::..|...|     |..:|:
Zfish    84 CQIMSKGVVAVLGPSASPASNSIISNICGEKEVPYVKVAPEDILKVQFPRFTTLDLRPTNTDISM 148

  Fly   141 NVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLADYADDY 205
            .||..|:..:.:            |..||....:.|..|:.|:....::.:.:.:|.|.|..|..
Zfish   149 AVAGLLTFFNSS------------TSCLICAQADCLLNLEVLLRQFLISKETLSVRMLDDSQDPT 201

  Fly   206 RILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFK 270
            .:|.:..|:  ....||:|........:|:.:.:..:...:..:.||.|:.....|.|:.::
Zfish   202 PLLKEIRDD--KTATIIVDANATMSHVILERASELGMLSVYYTYILTSLEFSLLRLDDLADQ--- 261

  Fly   271 ANITSVRLKVVDANPFERKKTRLTKVDQILG-NQT--------------MLPILIYDAVVLFASS 320
                  |:.:|..:.|.|  |.....|.:|. |::              :...|::|||
Zfish   262 ------RVNIVGFSVFNR--THPFFQDFVLSLNRSWQENCDHAPFAGTPLSSALLFDAV------ 312

  Fly   321 ARNVIAAMQPFHPPNR---------HCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEY 376
             ..|:||:|..   ||         .|.||..|..|..::|.::.:..:.:..|     ::.:..
Zfish   313 -HTVVAAVQEL---NRSQNVGATQLSCKSSKIWEHGTSLMNYLRMVELEGLTGH-----IEFNSK 368

  Fly   377 GQRIHFNLEIYKPTVNEPMMV--WTPDNGIKKRLLNLELESAGTTQDFSEQRKVYTVVTHYEEPY 439
            |||.::.|.|.:.:.:....:  |..:.|:.   :..:|.|...|....  ....|:.|..|.||
Zfish   369 GQRSNYALRIMQNSRDGLRQIGQWHSEQGLS---MERKLPSLNVTDTLF--NTTLTITTILENPY 428

  Fly   440 FMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKYN-PETK-QWDGIIRKLIDH 502
            .|::.:|:...|.::|||:.||::.:|:::::|.|...:| |:|.|. |... .|.|::.:||..
Zfish   429 VMLRANHQELEGNDRYEGFCVDMLKELADILKFKYRIRLV-GDGVYGVPGANGTWTGMVGELISR 492

  Fly   503 HAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLI 567
            .|.:.|..||||..|..|:||:.|||.|||||::..........|:||:||:..||::|:.|.|.
Zfish   493 KADLAVAALTITAEREKVIDFSKPFMTLGISIMYRVHIGRRPGYFSFLDPFSPGVWLFMLLAYLA 557

  Fly   568 MTLAFVFIARLSYREWLPPNPAIQDP-DELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILT 631
            ::.....:|||:..||..|:|.::.. ..|.|.:::.||.|..||..||||..|.||....|.::
Zfish   558 VSCVLFLVARLTPYEWYNPHPCLKGRCSLLINQYSLGNSFWFPVGGFMQQGSTIAPRALSTRCVS 622

  Fly   632 GMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDY 696
            |:||.|.|:::|:||||||||||..:.:..|:|:.||.:|..:.:|:|.||||..||..|....|
Zfish   623 GVWWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTMHGGSTMTFFQNSRYQTY 687

  Fly   697 QRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYG 761
            ||.||.|....||.|..:.:||:|||.  ...||:|:|:|...|..:|||:|||||..:..|.||
Zfish   688 QRMWNFMYSKQPSVFVKSTEEGIARVL--NSNYAYLLESTMNEYYRQRNCNLTQIGGLLDTKGYG 750

  Fly   762 LAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGDELSIIELGGVFLVLA 826
            :.:||||.||....::||:|.|...|:.:|.|||.......:..|...|  |.:..:||:|:||.
Zfish   751 IGMPLGSVYRDEFDLAILRLQEENRLEILKRKWWDGGKCPKEEDHRAKG--LGMENIGGIFVVLV 813

  Fly   827 GGVLIGVILGIFEFLWNVQN 846
            .|:|:.:.:.:.||:|.:::
Zfish   814 CGLLVAIFMAVLEFVWMLRH 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	75/353 (21%)
		ANF_receptor	46..386	CDD:279440	73/333 (22%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	150/372 (40%)
		Lig_chan	556..828	CDD:278489	111/272 (41%)
grik4	XP_021322087.1	Periplasmic_Binding_Protein_Type_1	26..400	CDD:324556	76/358 (21%)
grik4	XP_021322087.1	PBP2_iGluR_kainate_KA1	425..785	CDD:270442	148/362 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.750