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Protein Alignment GluRIIA and Grik2

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_062182.1	Gene:	Grik2 / 54257	RGDID:	2733	Length:	908	Species:	Rattus norvegicus

Alignment Length:	923	Identity:	291/923 - (31%)
Similarity:	461/923 - (49%)	Gaps:	129/923 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IIIIGFLEG---IIALGGDDRNEITVGAIFYENEK----EIELSFDQAFREVNN----MKFSELR 65
            ::.||:.:|   ::..||          ||...|.    ..||:|..|...:|.    :..:.|.
  Rat    23 LLWIGYSQGTTHVLRFGG----------IFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLT 77

  Fly    66 FVTIKRYMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATR 130
            :.|.|  :...|||...:..|:.:|.|||||||||..::::.|..|.||.|:|||
  Rat    78 YDTQK--INLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHI---------- 130

  Fly   131 QEQLNHQMS-------INVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQAL 188
            |.:..||:|       :::.|..|.||||..::::. ::|:|.|::|:...||.|||:|:...:.
  Rat   131 QTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQF-FKWKTVTVVYDDSTGLIRLQELIKAPSR 194

  Fly   189 NSDYVKLRNLADYADDYRILWKE--TDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFL 251
            .:..:|:|.|.....|.:.|.||  ..:.||   :|.||..:....:||.::...:...:.::..
  Rat   195 YNLRLKIRQLPADTKDAKPLLKEMKRGKEFH---VIFDCSHEMAAGILKQALAMGMMTEYYHYIF 256

  Fly   252 THLDTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQIL---------------- 300
            |.||.            |..::...|...|:...|....|..|:|..|:
  Rat   257 TTLDL------------FALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDS 309

  Fly   301 ----GNQTMLPILIYDAVVLFASSARNVIAAMQPFHP---PNRHCGSSSPWMLGAFIVNEMKTIS 358
                |..|....|:||||.:       |..|:|.|..   .:..|....||..|...::.:|
  Rat   310 GLLDGFMTTDAALMYDAVHV-------VSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIK--- 364

  Fly   359 EDDVEPHF----------KTENMKLDEYGQRIHFNLEI--YKPTVNEPMMVWTPDNGIKKRLLNL 411
                |.|:          ||..::.|       |:|::  .|....|.:..|.|.:|     ||:
  Rat   365 ----EAHWEGLTGRITFNKTNGLRTD-------FDLDVISLKEEGLEKIGTWDPASG-----LNM 413

  Fly   412 ELESAGTTQDFSE--QRKVYTVVTHYEEPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDY 474
            .....|...:.::  ..:...|.|..||||.:.|:..:...|.:::|||.:||:.:||.::.|.|
  Rat   414 TESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTY 478

  Fly   475 EFMIVNGNGKYNPE---TKQWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILH 536
            |..:|. :|||..:   ..||:|::|:||||.|.:.|..|.||.:|..|:||:.|||.||||||:
  Rat   479 EIRLVE-DGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY 542

  Fly   537 YKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPPNPAIQDPDELENIWN 601
            .|........|:||.|.:.::|:|::.|.|.::.....|||.|..||..|:|...|.|.:||.:.
  Rat   543 RKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFT 607

  Fly   602 VNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQ 666
            :.||.|..||::|:||.:::|:....||:.|:||||.|:::|:||||||||||..:.:|.|.|..
  Rat   608 LLNSFWFGVGALMRQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSAD 672

  Fly   667 DLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAF 731
            ||.:|.|:.:|::..|:|..||.:|..:.|.:.|..|.....|....:|:||:.||.  ...|||
  Rat   673 DLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVL--TSDYAF 735

  Fly   732 LMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWK 796
            |||:|::.:..:|||:|||||..|..|.||:..|:||.||..::::||||.|.|:|..||.|||:
  Rat   736 LMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWR 800

  Fly   797 NHNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILGIFEFLWNVQNVAVEERVTPWQAFKA 861
            .:.  |......:...|.:..:||:|:|||.|:::.|.:.:.|||:..:..|..|:.:...|...
  Rat   801 GNG--CPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVE 863

  Fly   862 ELIFALKFWVRKK 874
            ||..:||...|.|
  Rat   864 ELRMSLKCQRRLK 876

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.