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Protein Alignment GluRIIA and Gria1

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	NP_113796.1	Gene:	Gria1 / 50592	RGDID:	621531	Length:	907	Species:	Rattus norvegicus

Alignment Length:	882	Identity:	263/882 - (29%)
Similarity:	444/882 - (50%)	Gaps:	102/882 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IYAFIIIIGFLEGIIALGGDDRNEITVGAIFYENEKEIELSFDQAFREVNN--MKFSELRFVTIK 70
            |:|| ...|||..::  |.:..|.|.:|.:|...:.:...:|..|..::..  ....::..|.|
  Rat     4 IFAF-FCTGFLGAVV--GANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNI- 64

  Fly    71 RYMPTNDSFLLQQITCELISNGVAAIFGPSSKAASDIVAQIANATGIPHIEYDLKLEATRQEQLN 135
                 :|||.:....|...|.||.||||...:...:::.....|..:..|.....::.      :
  Rat    65 -----SDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDT------S 118

  Fly   136 HQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDYVKLRNLAD 200
            :|..:.:.|.   |..|...|| .:|:|:||..||:...||:.||.:::..|..:..|...|:..
  Rat   119 NQFVLQLRPE---LQEALISII-DHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILT 179

  Fly   201 YADD-YRILWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDI 264
            ..:: ||:|:::.::. .|:.:::|||.:.|..:|...:..:..|...::.|.:|     |..||
  Rat   180 TTEEGYRMLFQDLEKK-KERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANL-----GFMDI 238

  Fly   265 YNEDFK---ANITSVRL----KVVDANPFERKKTR----LTKVDQILGNQTMLPILIYDAVVL-- 316
            ....||   ||:|..:|    ..:.|...::.:|.    .|:||......|  ..|.||.|.:
  Rat   239 DLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDHTRVDWKRPKYT--SALTYDGVKVMA 301

  Fly   317 --FASSARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQR 379
              |.|..|..|...:..:..:.....:.||..|..|...::.:..:.:     |.|::.:|.|:|
  Rat   302 EAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGL-----TGNVQFNEKGRR 361

  Fly   380 IHFNLEIYKPTVNEPMMVWTPDNGIKK--------RLLNLELESAGTTQDFSEQRKVYTVVTHYE 436
            .::.|.:          :....:||:|        :.:....::.....:.|.|.:.|.|.|..|
  Rat   362 TNYTLHV----------IEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILE 416

  Fly   437 EPYFMMKEDHENFRGREKYEGYAVDLISKLSELMEFDYEFMIVNGNGKY---NPETKQWDGIIRK 498
            :||.|:|::...|.|.::||||.|:|.:::::.:.:.|...||: :|||   :|:||.|:|::.:
  Rat   417 DPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVS-DGKYGARDPDTKAWNGMVGE 480

  Fly   499 LIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIF 563
            |:...|.:.|..||||.:|..|:||:.|||.|||||:..|........|:||:|.|.|:|:.::|
  Rat   481 LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVF 545

  Fly   564 AQLIMTLAFVFIARLSYREWLPPNPAIQDPDELE-----------NIWNVNNSTWLMVGSIMQQG 617
            |.:.:::....::|.|..||        ..:|.|           |.:.:.||.|..:|:.||||
  Rat   546 AYIGVSVVLFLVSRFSPYEW--------HSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQG 602

  Fly   618 CDILPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGG 682
            |||.||....||:.|:||||.|:::|:||||||||||..:..|.|:|.:||.:|.::.:|::..|
  Rat   603 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAG 667

  Fly   683 STSLFFSESNDTDYQRAWNQMKDFNPSAFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERN-C 746
            ||..||..|....:::.|..||...||.|..|.:||:.||||.||.||:|:|:|...|..:|. |
  Rat   668 STKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPC 732

  Fly   747 DLTQIGEQIGEKHYGLAVPLGSDYRTNLSVSILQLSERGELQKMKNKWWKNHNVTCDSYHEVDGD 811
            |..::|..:..|.||:|.|.||..|..:::::|:|:|:|.|.|:|||||.:.. .|.|   ..||
  Rat   733 DTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKG-ECGS---GGGD 793

  Fly   812 E------LSIIELGGVFLVLAGGVLIGVILGIFEFLW 842
            .      ||:..:.|||.:|.||:.:.:::.:.||.:
  Rat   794 SKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCY 830

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.