Protein Alignment GluRIIA and KaiR1D

DIOPT Version :10

• Sequence 1: NP_523484.2
• Gene: GluRIIA / 33788
• FlyBaseID: FBgn0004620
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_061498559.1
• Gene: KaiR1D / 4576020
• VectorBaseID: AGAMI1_006981
• Length: 930
• Species: Anopheles gambiae
• Alignment Length: 913
• Identity: 343/913 - (37%)
• Similarity: 517/913 - (56%)
• Gaps: 86/913 - (9%)

  Fly    32 ITVGAIFYENEKEIELSFDQAFREVNN----MKFSELRFVTIKRYMPTNDSFLLQQITCELISNG 92
            |.:|.:|:.::...|::|..|..::|:    :..|:| ...|:|..| .||||..:..|.|:..|
Mosquito    33 IRIGGLFHPDDDHQEIAFRYAVEKINSDRTILPRSKL-LAQIERISP-QDSFLASKRVCHLLGVG 95

  Fly    93 VAAIFGPSSKAASDIVAQIANATGIPHIE--YDLKLEATRQEQLNHQMSINVAPSLSVLSRAYFE 155
            |||||||.|...:..|..|.:...|||:|  :|.:|   |:|    ...:|:.|..|.||:||.:
Mosquito    96 VAAIFGPQSSHTASHVQSICDTMEIPHLETRWDYRL---RRE----SCLVNLYPHPSTLSKAYVD 153

  Fly   156 IIKSNYEWRTFTLIYETPEGLARLQDLMNIQALNSDY-VKLRNLADYADDYRILWKETDETFHEQ 219
            ::.: :.|::||:||||.|||.|:|:|:....| ||| :.:|.|:| :.|||.|.|:...: .|.
Mosquito   154 LVAA-WGWKSFTIIYETNEGLVRMQELLKAHGL-SDYPITVRQLSD-SGDYRPLLKQIKNS-AES 214

  Fly   220 RIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHLDTHNSGLRDIYNEDFK---ANITSVRLKVV 281
            .|:|||..:.:.|:||.:....:...:.::.:|.||.|...|     ::||   .|||:.|| |.
Mosquito   215 HIVLDCSTERIYEVLKQAQQIGMMSDYHSYLITSLDLHTINL-----DEFKYGGTNITAFRL-VD 273

  Fly   282 DANP--------FERKKTRL-TKVD-QILGNQTML---PILIYDAVVLFASSARNVIAAMQ-PFH 332
            ..||        :...:.|| .||| :...|.|::   ..|:||||.|||.:..::..:.| ..|
Mosquito   274 PENPEVAQAIHNWTIGEARLGKKVDFKTAENVTVIKAETALMYDAVHLFAKALHDLDTSQQIDIH 338

  Fly   333 PPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFNLEIYK--PTVNEPM 395
            |.:  |.:...|..|..::|.||.     ||....|:.:|.|..|.|..|.|:|.:  |......
Mosquito   339 PLS--CDTQDTWPHGYSLINYMKI-----VEMRGLTDVIKFDHQGFRSDFVLDIVELGPQGLRKS 396

  Fly   396 MVWTPDNGIKKRLLNLELESAGTTQDFSEQR---------KVYTVVTHYEEPYFMMKEDHENFRG 451
            ..|...:|:            ..|:.:.||:         |...|.|....||.|.|:..|...|
Mosquito   397 GTWNSTSGV------------NFTRTYGEQQKEIVEILQNKTLIVTTILSAPYCMRKDSAEKLTG 449

  Fly   452 REKYEGYAVDLISKLSELMEFDYEFMIV-NGN-GKYNPETKQWDGIIRKLIDHHAQIGVCDLTIT 514
            ..::||||:|||.::|:::.|:|...:. :|. |.:|.||.:|||:|::|::..|.:.:.|||||
Mosquito   450 NSQFEGYAIDLIHEISKILGFNYTIRLAPDGRYGSHNKETGEWDGMIKELLEQRADLAIADLTIT 514

  Fly   515 QMRRSVVDFTVPFMQLGISILHYKSPPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLS 579
            ..|..|||||:|||.||||:|:.|...:|.|.|:||.|.:::|||||..|.|.:::....:||.:
Mosquito   515 FDREQVVDFTMPFMNLGISVLYRKPVKQPPNLFSFLSPLSLDVWIYMATAYLGVSVLLFILARFT 579

  Fly   580 YREWLPPNPAIQDPDELENIWNVNNSTWLMVGSIMQQGCDILPRGPHMRILTGMWWFFALMMLST 644
            ..||..|||....|::|:..:.:.|..|..:||:||||||.||:....|::.||||||.|:|:|:
Mosquito   580 PYEWPTPNPCDPHPEKLQTQFTLMNCMWFAIGSLMQQGCDFLPKAVSTRMVAGMWWFFTLIMISS 644

  Fly   645 YTANLAAFLTSNKWQSSIKSLQDLIEQDKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPS 709
            ||||||||||..:..|.|:|.:||.:|.|:.:|::|||||:.||.:||.:.|||.|:.|:...||
Mosquito   645 YTANLAAFLTVERMDSPIESAEDLAKQTKIKYGALRGGSTAAFFRDSNFSTYQRMWSFMESARPS 709

  Fly   710 AFTSTNKEGVARVRKEKGGYAFLMETTSLTYNIERNCDLTQIGEQIGEKHYGLAVPLGSDYRTNL 774
            .||::|.|||.||.|.||.||||||:||:.|.|||||:|||:|..:..|.||:|:|..|.:||.:
Mosquito   710 VFTASNIEGVERVVKGKGSYAFLMESTSIEYVIERNCELTQVGGMLDSKGYGIAMPPNSPFRTAI 774

  Fly   775 SVSILQLSERGELQKMKNKWWKNH--NVTC---DSYHEVDGDELSIIELGGVFLVLAGGVLIGVI 834
            |.::|:|.|.|:|..:|.:|||..  ..:|   .|......:||.:..:||||:||.||:.:..:
Mosquito   775 SGAVLKLQEEGKLHILKTRWWKEKRGGGSCRDDTSKSSSTANELGLANVGGVFVVLMGGMGVACV 839

  Fly   835 LGIFEFLWNVQNVAVEER-VTPWQAFKAELIFALKFWVRKKPMRISSSSDKSSSRRSSGSRRSSK 898
            :.:.||:|..:.|||||| |:......:||.|||| ..|.:|....|    ..:.|::.||.|.|
Mosquito   840 IAVCEFVWKSRKVAVEEREVSLCSEMASELRFALK-RNRAQPKHAGS----GGTLRTASSRASPK 899

  Fly   899 EKS 901
            :.:
Mosquito   900 DSA 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..405	CDD:380605	128/397 (32%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	173/380 (46%)
		Lig_chan	555..828	CDD:459656	129/277 (47%)
KaiR1D	XP_061498559.1	None