DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRIIA and grin2da

DIOPT Version :9

Sequence 1:	NP_523484.2	Gene:	GluRIIA / 33788	FlyBaseID:	FBgn0004620	Length:	907	Species:	Drosophila melanogaster
Sequence 2:	XP_009292354.1	Gene:	grin2da / 449864	ZFINID:	ZDB-GENE-041008-124	Length:	1916	Species:	Danio rerio

Alignment Length:	866	Identity:	190/866 - (21%)
Similarity:	347/866 - (40%)	Gaps:	183/866 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 SFLLQQITCELIS----NGVAAIF------GPSSKAASDIVAQIANATGIPHIEYDLKLEATRQE 132
            |.|||  .|||::    .|:  :|      .|:....:.::..::..||:|.|.........|:.
Zfish   125 SLLLQ--LCELLATTPLQGL--VFEEEKPPPPNRAPLAPMLEFVSAQTGVPVIAVGGGAGLGREP 185

  Fly   133 QLNHQMSINVAPSLSVLSRAYFEIIKSNYEWRTFTLIYETPEG----LARLQDLMNIQALNSD-- 191
            |.:..:.:..:.|..:.....||::: .::|..|:::.....|    ||.::.:::...:..:
Zfish   186 QESGSVYLQFSCSTDLQLEVIFEVLE-EFDWTAFSVVTTRHHGYEDFLAMVEGMIDGSFIGWERK 249

  Fly   192 YVKLRNLADYADDYRI--LWKETDETFHEQRIILDCEPKTLKELLKVSIDFKLQGPFRNWFLTHL 254
            .|.:.||.|.....|.  |.||.:    .|..:|.|..:..:::.|.:.......|...||..
Zfish   250 SVVMLNLTDDPGGARTRRLLKENE----AQVRLLYCSQEEAEQIFKAAWASGQATPSHMWFAV-- 308

  Fly   255 DTHNSGLRDIYNEDFKANITSVRLKVVDANPFERKKTRLTKVDQILGNQTMLPILIYDAVVLFAS 319
               ..||..:..|.....:.:||.:.....|    :.|:.|...:|.:..|.....|......:.
Zfish   309 ---GPGLSGLGLEGLPKALFAVRPQGWRDEP----RRRIAKGVSVLTHGAMALRREYGGARGTSF 366

  Fly   320 SARNVIAAMQPFHPPNRHCGSSSPWMLGAFIVNEMKTISEDDVEPHFKTENMKLDEYGQRIHFN- 383
            :...::...|....|.|                 ::..|           |:.|.  |:...||
Zfish   367 AGNCMMDGNQTQRVPGR-----------------IRFFS-----------NITLS--GRDYSFNN 401

  Fly   384 --------LEIYKPTVN---EPMMVWTPDNGIKKRLLNLELESAGTTQ--------DFSEQRKVY 429
                    |::...|..   |.:..|  :||:      |.|.....::        |.|:..:|.
Zfish   402 DGYLANPLLDVISYTAGRGWEEVGWW--ENGV------LRLRYPPWSRYGPFLKPLDDSQHLRVV 458

  Fly   430 TVVTHYEEPYFMMKEDHENFRG-------------------------REKYEGYAVDLISKLSEL 469
            |:    ||..|::.|..:...|                         :...:|:.:|::.:|:::
Zfish   459 TL----EERPFVIVEPADPGTGSCIRDSVPCRLPLNNSMVVEGIQSMKHCCKGFCIDVLKRLAKI 519

  Fly   470 MEFDYEFMIVNGNGKYNPETK-QWDGIIRKLIDHHAQIGVCDLTITQMRRSVVDFTVPFMQLGIS 533
            :.|.|:..:|. ||::..... ||:|::.:::...|.:.:..|||.:.|..||:|:|||::.|||
Zfish   520 VGFTYDLYLVT-NGRHGKNIDGQWNGMVGEVVSKRADMAIGSLTINEERSEVVEFSVPFVETGIS 583

  Fly   534 ILHYKS--PPEPKNQFAFLEPFAVEVWIYMIFAQLIMTLAFVFIARLSYREWLPP---NPAIQDP 593
            ::..:|  ...|.   |||||::..||:.|....|.:....|||.     |:..|   |.::|..
Zfish   584 VMVSRSNGTVSPS---AFLEPYSPAVWVMMFVMCLSVVAVTVFIF-----EFFSPVGYNRSLQSG 640

  Fly   594 DEL-ENIWNVNNSTWLMVGSIMQQGCDI-LPRGPHMRILTGMWWFFALMMLSTYTANLAAFLTSN 656
            ... .:.:.:..|.||:...:......: .|||...:|:..:|.|||::.|::||||||||:...
Zfish   641 KTAGGSKFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQE 705

  Fly   657 KWQSSIKSLQDL-----IEQ-DKVHFGSMRGGSTSLFFSESNDTDYQRAWNQMKDFNPSAFTSTN 715
            ::..::..|.|.     .|| ..:.||::..|||    .|:..::|......|        ...|
Zfish   706 EYIDTVSGLSDKKFQHPTEQYPPLRFGTVPNGST----EENIRSNYPNMHQYM--------VRNN 758

  Fly   716 KEGVA-RVRKEKGGY--AFLMETTSLTYNIERN--CDLTQI--GEQIGEKHYGLAVPLGSDYRTN 773
            :.||. .:...|.|.  ||:.:...|.|...::  |.:..|  |:......||:|:...|.::..
Zfish   759 QRGVEDAIENLKTGKLDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGVALHKNSRWKRP 823

  Fly   774 LSVSILQLSERGELQKMKNKWWKN--HNVTCDSYHEVDGDELSIIELGGVFLVLAGGVLIGVILG 836
            |.:::|||....|:..::..|...  ||   |.. ||...:|.|..:.|||.:|    |:.:.|.
Zfish   824 LDLALLQLVGDDEIDMLERLWLSGICHN---DKI-EVMSSKLDIDNMAGVFYML----LVAMGLS 880

  Fly   837 IFEFLWNVQNVAVEERVTPWQ 857
            :..|.|        |.:..|:
Zfish   881 LLVFAW--------EHLVYWK 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRIIA	NP_523484.2	PBP1_iGluR_Kainate	33..404	CDD:107377	64/355 (18%)
		ANF_receptor	46..386	CDD:279440	60/334 (18%)
		PBP2_iGluR_Kainate	426..796	CDD:270432	104/415 (25%)
		Lig_chan	556..828	CDD:278489	76/291 (26%)
grin2da	XP_009292354.1	PBP1_iGluR_NMDA_NR2	42..441	CDD:107373	67/371 (18%)
		PBP2_iGluR_NMDA_Nr2	452..851	CDD:270436	105/423 (25%)
		HisJ	<507..>590	CDD:223904	25/83 (30%)
		Lig_chan	605..877	CDD:278489	77/296 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591032
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830